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Mirdametinib Disease Interactions

There are 4 disease interactions with mirdametinib.

Moderate

Mirdametinib (applies to mirdametinib) cardiac disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Heart Disease, Cardiovascular Disease

Mirdametinib can cause left ventricular dysfunction (LVEF) and has not been studied in patients with a history of clinically significant cardiac disease or LVEF.

Moderate

Mirdametinib (applies to mirdametinib) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Mirdametinib has not been studied in patients with moderate or severe liver dysfunction. No dose adjustment is recommended in patients with mild liver dysfunction.

Moderate

Mirdametinib (applies to mirdametinib) ocular toxicity

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Visual Defect/Disturbance

Mirdametinib can cause ocular toxicity including retinal vein occlusion (RVO), retinal pigment epithelium detachment (RPED), and blurred vision. A comprehensive ophthalmic assessment prior to initiating treatment, and at regular intervals during treatment is recommended.

Moderate

Mirdametinib (applies to mirdametinib) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Mirdametinib has not been studied in patients with severe renal dysfunction. No dose adjustment is recommended in patients with mild or moderate renal dysfunction.

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Mirdametinib drug interactions

There are 10 drug interactions with mirdametinib.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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