Desferal Disease Interactions
There are 5 disease interactions with Desferal (deferoxamine).
Deferoxamine (applies to Desferal) renal dysfunction
Major Potential Hazard, High plausibility.
The use of deferoxamine is contraindicated in patients with severe renal impairment or anuria. Deferoxamine chelates iron and the complexes are primarily eliminated by the kidney.
Deferoxamine (applies to Desferal) auditory dysfunction
Moderate Potential Hazard, High plausibility. Applicable conditions: Hearing Loss
Neurotoxicity-related auditory abnormalities such as tinnitus and hearing loss including deafness have occurred after prolonged therapy or large doses of deferoxamine, or in patients with low ferritin levels. Therapy with deferoxamine should be administered cautiously in patients with hearing impairment. Hearing toxicity is usually reversible if detected early and deferoxamine discontinued.
Deferoxamine (applies to Desferal) hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
No studies of deferoxamine have been performed in patients with hepatic impairment. Caution is advised.
Deferoxamine (applies to Desferal) ocular dysfunction
Moderate Potential Hazard, High plausibility. Applicable conditions: Visual Defect/Disturbance
Deferoxamine may cause blurred vision, cataracts, decreased visual acuity, and impaired color, peripheral, and night vision. Ocular toxicities have occurred after prolonged therapy, large doses, and in patients with decreased ferritin levels. Therapy with deferoxamine should be administered cautiously in patients with or predisposed to visual defects. Periodic examination of visual acuity is recommended in patients receiving long term deferoxamine therapy. Ocular dysfunction is usually reversible if detected early and deferoxamine is withdrawn promptly.
Deferoxamine (applies to Desferal) respiratory distress syndrome
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Thalassemia
Acute respiratory distress syndrome has been described in patients with acute iron intoxication or thalassemia following treatment with excessively high intravenous doses of deferoxamine. Caution is recommended when using deferoxamine in these patients.
Desferal drug interactions
There are 33 drug interactions with Desferal (deferoxamine).
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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