Clavulanate Disease Interactions
There is 1 disease interaction with clavulanate:
Amoxicillin-Clavulanate (Includes Clavulanate) ↔ Hepatotoxicity
Moderate Potential Hazard, Moderate plausibility
Applies to: Liver Disease
The administration of amoxicillin-clavulanate has infrequently been associated with hepatotoxicity such as elevations in serum transaminases, bilirubin, and/or alkaline phosphatase. The histologic findings on liver biopsy have consisted of predominantly cholestatic and/or hepatocellular changes. Symptoms may occur during or several weeks after therapy. The hepatotoxicity is generally reversible, although deaths have been reported on rare occasions, mostly in patients with serious underlying diseases or concomitant use of other medications. Liver enzyme abnormalities have also been observed with the use of amoxicillin or ampicillin alone. According to the manufacturer, therapy with amoxicillin-clavulanate should be administered cautiously in patients with evidence of hepatic dysfunction. Periodic monitoring of liver function is recommended during prolonged therapy. The use of amoxicillin-clavulanate is contraindicated in patients with a history of cholestatic jaundice or hepatic dysfunction associated with the drug.
- Ryley NG, Fleming KA, Chapman RWG "Focal destructive cholangiopathy associated with amoxycillin/clavulanic acid (augmentin)." J Hepatol 23 (1995): 278-82
- "Product Information. Augmentin (amoxicillin-clavulanate)." SmithKline Beecham, Philadelphia, PA.
- Dowsett JF, Gillow T, Heagerty A, Radcliffe M, Toadi R, Isle I, Russell RC "Amoxycillin/clavulanic acid (augmentin)-induced intrahepatic cholestasis." Dig Dis Sci 34 (1989): 1290-3
- Verhamme M, Ramboer C, Van De Bruaene P, Inderadjaja N "Cholestatic hepatitis due to an amoxycillin/clavulanic acid preparation." J Hepatol 9 (1989): 260-4
- Larrey D, Vial T, Micaleff A, et al. "Hepatitis associated with amoxycillin-clavulanic acid combination report of 15 cases." Gut 33 (1992): 368-71
- Silvain C, Fort E, Levillain P, Labat-Labourdette J, Beauchant M "Granulomatous hepatitis due to combination of amoxacillin and clavulanic acid." Dig Dis Sci 37 (1992): 150-2
- Wong FS, Ryan J, Dabkowski P, Dudley FJ, Sewell RB, Smallwood RA "Augmentin-induced jaundice." Med J Aust 154 (1991): 698-701
- Hebbard GS, Smith KG, Gibson PR, Bhathal PS "Augmentin-induced jaundice with a fatal outcome." Med J Aust 156 (1992): 285-6
- Thomson JA, Fairley CK, Ugoni AM, Forbes AB, Purcell PM, Desmond PV, Smallwood RA, Mcneil JJ "Risk factors for the development of amoxycillin-clavulanic acid associated jaundice." Med J Aust 162 (1995): 638-40
- Limauro DL, ChanTompkins NH, Carter RW, Brodmerkel GJ, Agrawal RM "Amoxicillin/clavulanate-associated hepatic failure with progression to Stevens-Johnson syndrome." Ann Pharmacother 33 (1999): 560-4
- Friess G, Wienbeck M "Cholestatic jaundice after taking amoxicillin and clavulanic acid." Dtsch Med Wochenschr 120 (1995): 1356-60
- Garcia Rodriguez LA, Stricker BH, Zimmerman HJ "Risk of acute liver injury associated with the combination of amoxicillin and clavulanic acid" Arch Intern Med 156 (1996): 1327-32
- Habior A, Walewskazielecka B, Butruk E "Hepatocellular-cholestatic liver injury due to amoxycillin-clavulanic acid combination." Clin Investig 72 (1994): 616-8
clavulanate drug Interactions
There are 24 drug interactions with clavulanate
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.