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Centrum Singles-Beta Carotene Disease Interactions

There are 2 disease interactions with Centrum Singles-Beta Carotene (beta-carotene).

Major

Vitamin A (applies to Centrum Singles-Beta Carotene) hepatobiliary dysfunction

Major Potential Hazard, High plausibility. Applicable conditions: Liver Disease, Biliary Obstruction

Vitamin A (including beta-carotene) is fat soluble and requires bile for adequate intestinal absorption. Hepatic and/or biliary dysfunction decrease the absorption of vitamin A. Vitamin A is metabolized by the liver and primarily excreted in bile and feces. Beta-carotene is primarily metabolized in the GI mucosa to vitamin A. Hepatic and/or biliary impairment can alter the metabolic and therapeutic activity of Vitamin A.

Moderate

Vitamin A (applies to Centrum Singles-Beta Carotene) malabsorption syndromes

Moderate Potential Hazard, Moderate plausibility.

Absorption of vitamin A depends on the presence of bile and absorbable fat in the GI tract. Prolonged fat malabsorption (cystic fibrosis, hepatic cirrhosis, sprue) or malabsorption syndromes (celiac disease, GI resection) can decrease the absorption of Vitamin A. Water- miscible vitamin A formulations may be an appropriate alternative in malabsorption conditions for certain conditions requiring vitamin A therapy.

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Centrum Singles-Beta Carotene drug interactions

There are 2 drug interactions with Centrum Singles-Beta Carotene (beta-carotene).

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More about Centrum Singles-Beta Carotene (beta-carotene)

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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