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Amivantamab-vmjw (Intravenous)

Medically reviewed by Last updated on Aug 6, 2022.

Commonly used brand name(s)

In the U.S.

  • Rybrevant

Available Dosage Forms:

  • Solution

Pharmacologic Class: Amivantamab

Uses for amivantamab-vmjw

Amivantamab-vmjw injection is used to treat non-small cell lung cancer (NSCLC) that has spread (metastatic) or cannot be removed by surgery or radiation (locally advanced) in patients who have an abnormal epidermal growth factor receptor (EGFR) gene (exon 20 insertion mutations) and have received other cancer medicines (eg, platinum) but did not work well. Your doctor will perform a test before you take amivantamab-vmjw.

Amivantamab-vmjw is to be given only by or under the supervision of your doctor.

Before using amivantamab-vmjw

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For amivantamab-vmjw, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to amivantamab-vmjw or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of amivantamab-vmjw injection in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amivantamab-vmjw injection in the elderly.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of amivantamab-vmjw. Make sure you tell your doctor if you have any other medical problems, especially:

  • Lung or breathing problems (eg, interstitial lung disease, pneumonitis), history of—Use with caution. May make these conditions worse.

Proper use of amivantamab-vmjw

Medicines used to treat cancer are very strong and can have many side effects. Before receiving amivantamab-vmjw, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

A nurse or other trained health professional will give you amivantamab-vmjw in a medical facility. It is given through a needle placed into one of your veins. Amivantamab-vmjw is usually given every week for 4 weeks.

Amivantamab-vmjw comes with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Your doctor will give you other medicines (eg, allergy medicine, fever medicine, steroid) before you receive amivantamab-vmjw to help prevent unwanted effects.

Missed dose

Amivantamab-vmjw needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Precautions while using amivantamab-vmjw

It is very important that your doctor check your progress closely while you are receiving amivantamab-vmjw. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

Receiving amivantamab-vmjw while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment. Use an effective form of birth control to keep from getting pregnant during treatment and for at least 3 months after the last dose. If you think you have become pregnant while receiving amivantamab-vmjw, tell your doctor right away.

Amivantamab-vmjw may cause infusion-related reactions, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you start to have a fever, chills or shaking, dizziness, trouble breathing, itching or rash, lightheadedness or fainting after receiving amivantamab-vmjw.

Check with your doctor right away if you have chest pain, chills, cough, fever, general feeling of discomfort or illness, trouble breathing, or thickening of bronchial secretions. These may be symptoms of lung problem (eg, interstitial lung disease, pneumonitis).

Amivantamab-vmjw may cause serious skin reactions (eg, dermatitis acneiform, toxic epidermal necrolysis). Check with your doctor right away if you have acne, blistering, crusting, irritation, itching, or reddening of the skin, chills, cough, cracked, dry, or scaly skin, diarrhea, itching, joint or muscle pain, peeling or loosening of the skin, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swelling, or unusual tiredness or weakness.

Amivantamab-vmjw may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps, outdoors and tanning beds for at least 2 months after the last dose.

Check with your doctor right away if blurred vision, difficulty with reading, eye pain, or any other change in vision occurs while you are receiving amivantamab-vmjw. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor).

Amivantamab-vmjw side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  • Back pain
  • bleeding gums
  • blistering, crusting, irritation, itching, or reddening of the skin
  • blood in the urine
  • bloody nose
  • burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings
  • chest pain or tightness
  • chills
  • cough
  • coughing or spitting up blood
  • cracked, dry, or scaly skin
  • dry, itching skin
  • fever
  • flushing
  • headache
  • loosening of the fingernails
  • muscle or bone pain
  • nausea and vomiting
  • nerve pain
  • rash with flat lesions or small raised lesions on the skin
  • redness or soreness around the fingernails
  • sneezing
  • swelling
  • trouble breathing
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

Less common

  • Anxiety
  • dizziness or lightheadedness
  • fainting
  • fast heartbeat
  • general feeling of discomfort or illness
  • thickening of bronchial secretions


  • Blistering, peeling, or loosening of the skin
  • blurred vision or other change in vision
  • diarrhea
  • eye redness, irritation, or pain
  • red irritated eyes
  • red skin lesions, often with a purple center
  • sensitivity of the eye to light
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • tearing
  • unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Canker sores
  • chapped, red, or swollen lips
  • constipation
  • decreased appetite
  • difficulty in moving
  • lack or loss of strength
  • muscle aches, cramps, or stiffness
  • pain in the arms or legs
  • pain in the joints
  • redness, swelling, or soreness of the tongue
  • scaling, redness, burning, pain, or other signs of inflammation of the lips
  • stomach pain
  • swelling or inflammation of the mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.