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How is Rybrevant administered?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Sep 13, 2021.

Official answer


Rybrevant is given as an intravenous (IV) infusion into your vein weekly for four weeks, then it is given every two weeks. Your first dose will be split into two infusions given on two consecutive days. Your healthcare provider will administer this medication.

Patients usually receive this medicine until their cancer worsens or they have side effects that require the drug to be stopped. Your doctor will determine your dose (based on your weight), how many treatments you will receive, and how often you receive them.

Infusion reactions are common with Rybrevant. You will receive medicines before each dose (called "premedications") to help reduce your risk of an infusion-related reaction.

Symptoms of the infusion-related reaction may include:

  • shortness of breath
  • flushing
  • fever
  • chills
  • nausea
  • chest discomfort
  • low blood pressure
  • vomiting.

Tell your doctor right away if you have any of these side effects. Your doctor may need to temporarily stop your infusion, decrease your dose or completely stop your treatment with Rybrevant if you have serious side effects.

What is Rybrevant used for?

Rybrevant (amivantamab-vmjw) is a prescription medicine used to treat adults with non-small cell lung cancer (NSCLC) that has spread in the body or cannot be removed by surgery.

  • Patients who receive Rybrevant have certain abnormal epidermal growth factor receptor “EGFR” genes and their NSCLC has worsened while on or after chemotherapy that contains platinum.
  • Your doctor can perform a blood test to make sure you can receive Rybrevant.

Related: Rybrevant side effects (in more detail)

Can it be administered at home?

Rybrevant is not normally given at your home. You would typically receive this medicine in a healthcare facility or clinic with appropriate personnel, medicine and equipment so you can be monitored and treated for any infusion-related reactions. Your doctor will tell you when and where you will receive your infusion.

If you miss your appointment, call your healthcare provider as soon as possible to reschedule.

This is not all the information you need to know about Rybrevant (amivantamab-vmjw) for safe and effective use and does not take the place of talking to your doctor about your treatment. Review the full Rybrevant information here, and discuss this information and any questions you have with your doctor or other health care provider.


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