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Mis-A (Multisymptom Inflammatory Syndrome in Adults)

Medically reviewed by Last updated on Jul 4, 2022.


Multisymptom inflammatory syndrome in adults (MIS-A)

is a group of symptoms that develops as a complication of coronavirus disease 2019 (COVID-19). Inflammation develops in areas such as your heart, digestive system, skin, or brain. MIS-A may develop days or weeks after you were infected with the virus that causes COVID-19. You can develop MIS-A even if you did not know you were infected. MIS-A is a serious health problem that needs immediate care.

Signs and symptoms of MIS-A may include any of the following:

  • A fever
  • Very low blood pressure
  • Abdominal pain, vomiting, or diarrhea
  • Neck pain
  • A skin rash or bloodshot eyes (whites of the eyes are reddish)
  • Chest pain or a tight feeling in your chest
  • Being more tired than usual

Call your local emergency number (911 in the US) or have someone call if:

  • You have trouble breathing.
  • You have severe chest pain.
  • You are confused.
  • You cannot be woken, or you have trouble staying awake during the day.

Seek care immediately if:

  • Your lips or nails are pale or look blue.
  • You have severe pain in your stomach.

Call your doctor if:

  • You have new or worsening symptoms.
  • You have questions or concerns about your condition or care.


MIS-A usually needs to be treated in the hospital. You may be given extra fluid. Medicines may be given to reduce inflammation or other symptoms. You may need to stay in the intensive care unit (ICU) if MIS-A becomes severe.

  • Medicines may be used to reduce inflammation, prevent blood clots, or treat or prevent a bacterial infection.
  • Liquids may be given if you are dehydrated.
  • Oxygen may be needed if the level in your blood is too low.

Follow up with your doctor as directed:

Write down your questions so you remember to ask them during your visits.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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