Azacitidine Plus Venetoclax Chemo Regimen
Medically reviewed by Drugs.com. Last updated on Dec 2, 2024.
Azacitidine plus venetoclax chemo regimen:
Your doctor will prescribe your dose and schedule. You may receive these medicines while you are in a hospital or cancer treatment center. The medicines need to be given on a fixed schedule. If you need to miss a dose, call your doctor or treatment clinic immediately. The following infusion cycle will repeat every 28 days:
- Azacitidine IV over 15 minutes, days 1, 2, 3, 4, 5, 6, and 7
- Venetoclax by mouth:
- Day 1: 1 tablet
- Day 2: 2 tablets
- Day 3: 4 tablets
- Day 4 through end of regimen: 4 tablets daily
Before you receive these medicines:
- Ask questions if you do not understand what your doctor or nurse is telling you about the medicines. Make sure you understand all the risks and benefits of this treatment.
- Talk to your doctor about all your current medicines and supplements. Do not take any medicines or supplements unless they have been discussed with your doctor.
- Tell your doctor if you have kidney disease, liver disease, gout, or a history of high uric acid blood levels.
- Talk to your doctor about pregnancy. Medicines in this regimen may harm an unborn baby. Use an effective form of birth control during treatment and for up to 3 months after the last dose, as directed.
- Do not breastfeed during treatment and for at least 1 week after the last dose.
On infusion days:
- Medicines may be given to help with nausea and vomiting and to decrease your risk for reactions.
- Blood may be drawn to make sure the doses you are being given are right for you. You may need blood tests often during the first few days of treatment. X-ray, MRI, or CT pictures may be used to check for infection or bleeding if you are at risk for these. Your doctor will use the results of all your tests to decide if the treatment should continue as planned. Your doctor may lower doses, wait to give a dose until side effects go away, or switch you to a different treatment plan.
Infusion precautions:
- Contact your doctor or nurse immediately if you feel short of breath or have trouble breathing during or after your infusion.
- Tell the doctor or nurse right away if you notice redness, pain, or swelling at the infusion site.
After infusions:
- If possible, have someone stay with you to call for help if you have serious side effects.
- Drink extra liquids to help prevent nausea and to keep your kidneys and liver working well.
- You may be at risk for infections. Wash your hands often with soap and water. Do not have close contact with anyone who is sick. Ask your doctor about vaccines you may need to prevent infections.
Call your local emergency number (911 in the US) if you have any of the following:
- Chest pain
- Trouble breathing
- Seizures or confusion
Call your nurse or doctor immediately if you have any of the following:
- Hives, swelling in your lips, face, or throat, headache, lightheadedness, fainting, flushing
- Joint pain, stiffness, or swelling
- Decrease in how much or how often you urinate, pain when you urinate, or lower back or side pain
- Unusual bleeding, bruising, or weakness
- Blood in your urine or bowel movements
- Dry mouth, increased thirst, muscle cramps, nausea or vomiting, or an uneven heartbeat
- Rapid weight gain, or swelling in your hands, ankles, feet, or face
- Fever, chills, cough, sore throat, or body aches
Talk to your nurse or doctor if you have any of the following:
- Pain, redness, or swelling at the infusion site
- Diarrhea, nausea, vomiting, or constipation
- Stomach pain or loss of appetite
Follow up with your oncologist as directed:
Your oncologist will need to check your progress at regular visits. Blood tests may be needed to check for side effects.
Care Agreement
You have the right to help plan your care. Learn about your health condition and how it may be treated. Discuss treatment options with your healthcare providers to decide what care you want to receive. You always have the right to refuse treatment. The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.© Copyright Merative 2024 Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.
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