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Alpha-1-Antitrypsin Deficiency in Children

Medically reviewed by Drugs.com. Last updated on Mar 3, 2024.

What is alpha-1 antitrypsin deficiency?

Alpha-1 antitrypsin deficiency (AATD) is a condition that increases your child's risk for lung and liver damage. Alpha-1 antitrypsin (AAT) is made by your child's liver and protects his or her lungs and liver from infections. Your child's body may not be able to make enough AAT if he or she was born with abnormal genes that make AAT. If the AAT his or her liver makes is faulty, it can cause liver inflammation, damage, and may lead to liver failure. Your child may also develop AATD if tobacco smoke or chemical fumes decrease the AAT levels.

What are the signs and symptoms of alpha-1 antitrypsin deficiency?

How is alpha-1 antitrypsin deficiency diagnosed?

How is alpha-1 antitrypsin deficiency treated?

There is no cure for AATD. Treatment depends on your child's health condition and which organs are damaged. He or she may need medicine or other treatments to help prevent medical problems. He or she may need treatment to help his or her body use nutrition.

How can I help my child with alpha-1 antitrypsin deficiency?

Be proactive to help your child cope with his or her condition and prevent other health problems:

What are the risks of alpha-1 antitrypsin deficiency?

When should I contact my child's healthcare provider?

Contact your child's healthcare provider if:

When should I seek immediate help?

Seek care immediately or call 911 if:

Where can I find support and more information?

Care Agreement

You have the right to help plan your child's care. Learn about your child's health condition and how it may be treated. Discuss treatment options with your child's healthcare providers to decide what care you want for your child. The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.