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Unituxin

Generic Name: Dinutuximab (din ue TUX i mab)
Brand Name: Unituxin

Medically reviewed on Sep 5, 2018

Warning

  • Very bad and sometimes life-threatening infusion reactions have happened with Unituxin (dinutuximab). Most of the reactions happened during or within 24 hours after the infusion. Other drugs will be given before the infusion to help with infusion side effects. Fluids will also need to be started before the infusion to avoid low blood pressure. Talk with the doctor.
  • You will be watched closely while you receive Unituxin (dinutuximab) and for at least 4 hours after your dose. Tell your doctor right away if you have any bad effects like chills, dizziness or passing out, fever, itching, swelling of the face or lips, or trouble breathing during or after the infusion.
  • This medicine may cause very bad nerve problems or pain like arm, leg, back, chest, joint, nerve, or stomach pain. An opioid like morphine or other pain drug will be given before, during, and for 2 hours after the infusion. Tell your doctor right away if you have severe pain or pain that gets worse. Tell your doctor right away if you have signs of nerve problems like burning, numbness, tingling, weakness, trouble passing urine, or not able to control bladder or bowels.

Uses of Unituxin:

  • It is used to treat neuroblastoma, a cancer of the nervous system.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Unituxin?

  • If you have an allergy to Unituxin (dinutuximab) or any part of Unituxin (dinutuximab).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you are breast-feeding. Do not breast-feed while you take Unituxin (dinutuximab).

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Unituxin (dinutuximab) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Unituxin?

  • Tell all of your health care providers that you take Unituxin (dinutuximab). This includes your doctors, nurses, pharmacists, and dentists.
  • If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
  • This medicine may cause a very bad and sometimes deadly problem called capillary leak syndrome (CLS). CLS may lead to low blood pressure and harm to the body. It may also lead to a heartbeat that is not normal, chest pain or pressure, heart attack, lung or breathing problems, bleeding or lower blood flow in the stomach or bowel, kidney problems, swelling, or feeling confused. Talk with the doctor.
  • You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
  • Tell your doctor if you have signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Talk with your doctor before getting any vaccines. Use with Unituxin (dinutuximab) may either raise the chance of an infection or make the vaccine not work as well.
  • Have your blood pressure checked often. Talk with your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant.
  • Use birth control that you can trust during care and for 2 months after care ends.
  • If you get pregnant while taking Unituxin (dinutuximab) or within 2 months after your last dose, call your doctor right away.

How is this medicine (Unituxin) best taken?

Use Unituxin (dinutuximab) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as an infusion into a vein over a period of time.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Blurred eyesight, change in pupil size, loss of eyesight, or other eye or eyesight changes.
  • If bright lights bother your eyes.
  • Dizziness or passing out.
  • A fast heartbeat.
  • Feeling very tired or weak.
  • Pale skin.
  • Swelling.
  • A very bad and sometimes deadly brain problem called posterior reversible encephalopathy syndrome (PRES) has happened with Unituxin (dinutuximab). Call your doctor right away if you have signs like feeling confused, lowered alertness, change in eyesight, loss of eyesight, seizures, or very bad headache.
  • This medicine may cause a health problem called hemolytic-uremic syndrome. Very bad problems may happen in some patients who get this health problem. Call your doctor right away if you are feeling very tired or weak or have any signs of bleeding or bruising, change in color of urine, change in how much urine is passed, a fever, or swelling of the face, hands, feet or body.

What are some other side effects of Unituxin?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Loose stools (diarrhea).
  • Not hungry.
  • Upset stomach or throwing up.
  • Weight gain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Unituxin?

  • If you need to store Unituxin (dinutuximab) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Unituxin (dinutuximab), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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