Isosorbide dinitrate extended-releasePronunciation
Generic Name: isosorbide dinitrate (EYE-soe-SOR-bide dye-NYE-trate)
Brand Name: Dilatrate-SR
Isosorbide dinitrate extended-release is used for:
Preventing symptoms of angina (chest pain) caused by heart disease. Isosorbide dinitrate extended-release is used alone or with other medicines. Isosorbide dinitrate extended-release is NOT intended for the immediate relief of acute attacks of angina. It may also be used for other conditions as determined by your doctor.
Isosorbide dinitrate extended-release is a nitrate. It works by relaxing the blood vessels in the body, allowing them to widen. This lets more blood flow through the blood vessels, which reduces the work the heart has to do to pump blood. This reduces the oxygen needs of the heart and makes chest pain go away.
Do NOT use isosorbide dinitrate extended-release if:
- you are allergic to any ingredient in isosorbide dinitrate extended-release
- you are taking avanafil, riociguat, sildenafil, tadalafil, or vardenafil
Contact your doctor or health care provider right away if any of these apply to you.
Before using isosorbide dinitrate extended-release:
Some medical conditions may interact with isosorbide dinitrate extended-release. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have bleeding in the brain, a recent head trauma, a heart attack, an overactive thyroid, or anemia (a low red blood cell count)
Some MEDICINES MAY INTERACT with isosorbide dinitrate extended-release. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Avanafil, riociguat, sildenafil, tadalafil, or vardenafil because the risk of severe low blood pressure may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if isosorbide dinitrate extended-release may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use isosorbide dinitrate extended-release:
Use isosorbide dinitrate extended-release as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take isosorbide dinitrate extended-release by mouth on an empty stomach with a full glass of water (8 oz [240 mL]).
- Swallow isosorbide dinitrate extended-release whole. Do not break, crush, or chew before swallowing.
- If you miss a dose of isosorbide dinitrate extended-release, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use isosorbide dinitrate extended-release.
Important safety information:
- Isosorbide dinitrate extended-release may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use isosorbide dinitrate extended-release with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Isosorbide dinitrate extended-release may cause dizziness or light-headedness; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Check with your doctor before you drink alcohol while you are taking isosorbide dinitrate extended-release. Drinking alcohol may increase the risk of low blood pressure with isosorbide dinitrate extended-release.
- Isosorbide dinitrate extended-release may give you daily headaches. This should become less noticeable with time. Do not change how you use isosorbide dinitrate extended-release to avoid these headaches. Talk with your doctor for ways to lessen this side effect.
- Isosorbide dinitrate extended-release should not be used to stop an attack of angina; it is intended only for prevention of an attack.
- Isosorbide dinitrate extended-release may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking isosorbide dinitrate extended-release.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using isosorbide dinitrate extended-release while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use isosorbide dinitrate extended-release, check with your doctor. Discuss any possible risks to your baby.
When used for long periods of time or at high doses, isosorbide dinitrate extended-release may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if isosorbide dinitrate extended-release stops working well. Do not take more than prescribed. Some people who use isosorbide dinitrate extended-release for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as physical DEPENDENCE. If you stop taking isosorbide dinitrate extended-release suddenly, you may have WITHDRAWAL symptoms. These may include rapid heartbeat, chest pain, and even heart attack.
Possible side effects of isosorbide dinitrate extended-release:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Dizziness; flushing of the face and neck; headache; light-headedness; nausea; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; fast or slow heartbeat; new or worsening chest pain; severe or persistent dizziness or headache.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of isosorbide dinitrate extended-release:
Store isosorbide dinitrate extended-release at room temperature between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep isosorbide dinitrate extended-release out of the reach of children and away from pets.
- If you have any questions about isosorbide dinitrate extended-release, please talk with your doctor, pharmacist, or other health care provider.
- Isosorbide dinitrate extended-release is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take isosorbide dinitrate extended-release or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about isosorbide dinitrate extended-release. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to isosorbide dinitrate extended-release. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using isosorbide dinitrate extended-release.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about isosorbide dinitrate
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