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Iobenguane I 131

Generic Name: Iobenguane I 131 (eye oh BEN gwane eye one THUR tee one)
Brand Name: Azedra Dosimetric, Azedra Therapeutic

Medically reviewed by Drugs.com. Last updated on Jun 10, 2019.

Uses of Iobenguane I 131:

  • It is used to treat a tumor on the adrenal gland called pheochromocytoma or another type of tumor called paraganglioma.

What do I need to tell my doctor BEFORE I take Iobenguane I 131?

  • If you have an allergy to iobenguane or any other part of iobenguane I 131.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Low white blood cell count, low platelet count, or low red blood cell count.
  • If you are breast-feeding. Do not breast-feed during treatment and for 80 days after your last dose.

This is not a list of all drugs or health problems that interact with iobenguane I 131.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take iobenguane I 131 with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Iobenguane I 131?

  • Tell all of your health care providers that you take iobenguane I 131. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • There are many drugs that need to be stopped some time before you get iobenguane I 131. These drugs may cause iobenguane I 131 to not work as well. These drugs can be started again 7 days after you get iobenguane I 131. Check with your doctor and pharmacist to see if any of your drugs (prescription or OTC, natural products, vitamins) interact with iobenguane I 131.
  • High blood pressure has happened with iobenguane I 131. Have your blood pressure checked as you have been told by your doctor.
  • A drug to protect the thyroid gland will be given to you. Take it as you have been told. If this is not done, the chance of thyroid cancer later in life may be raised. Talk with your doctor.
  • This medicine is radioactive. You will need to follow what the doctor has told you to lessen being exposed to iobenguane I 131. Talk with the doctor.
  • Rarely, a bone marrow problem called myelodysplastic syndrome (MDS) has happened in patients treated with iobenguane I 131. A type of leukemia has also rarely happened. If you have questions, talk with the doctor.
  • Other types of cancer may rarely happen later in life.
  • Some people have had lung problems with iobenguane I 131. Sometimes, this has been deadly. Call your doctor right away if you have signs of lung problems like shortness of breath or other trouble breathing, cough that is new or worse, or fever.
  • Use with care in children. Talk with the doctor.
  • This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. In both men and women, this may go back to normal but sometimes it may not. Talk with your doctor.
  • If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during treatment and for at least 4 months after your last dose.
  • If you are a man and your sex partner gets pregnant while you take iobenguane I 131 or within 4 months after your last dose, call your doctor right away.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant.
  • If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting iobenguane I 131. Talk with your doctor.
  • Use birth control that you can trust to prevent pregnancy while taking iobenguane I 131 and for at least 7 months after stopping iobenguane I 131.
  • If you get pregnant while taking iobenguane I 131 or within 7 months after your last dose, call your doctor right away.

How is this medicine (Iobenguane I 131) best taken?

Use iobenguane I 131 as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as an infusion into a vein over a period of time.
  • Drink at least 2 liters (8 cups) of noncaffeine liquids starting at least 1 day before and for 1 week after each dose as your doctor has told you.
  • Other drugs may be given with iobenguane I 131 to help avoid side effects.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain.
  • Signs of low thyroid levels like constipation; not able to handle cold; memory problems; mood changes; or a burning, numbness, or tingling feeling that is not normal.
  • Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Signs of dehydration like dry skin, mouth, or eyes; thirst; fast heartbeat; dizziness; fast breathing; or confusion.
  • Any unexplained bruising or bleeding.
  • Feeling very tired or weak.
  • Chest pain or pressure or a fast heartbeat.
  • A heartbeat that does not feel normal.
  • Very bad dizziness or passing out.
  • Swelling of belly.

What are some other side effects of Iobenguane I 131?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Iobenguane I 131?

  • If you need to store iobenguane I 131 at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about iobenguane I 131, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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