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Impavido

Generic Name: Miltefosine (mil TEF oh seen)
Brand Name: Impavido

Medically reviewed on Sep 5, 2018

Warning

  • Do not take if you are pregnant.
  • Use of Impavido (miltefosine) during pregnancy may cause birth defects or death of the unborn baby. You will need to have a pregnancy test to show that you are NOT pregnant before starting Impavido (miltefosine). Talk with the doctor.
  • Use birth control you can trust to prevent pregnancy while you are taking Impavido (miltefosine) and for 5 months after you stop taking it.
  • If you get pregnant while taking Impavido (miltefosine) or within 5 months after your last dose, call your doctor right away.

Uses of Impavido:

  • It is used to treat a certain type of infection (leishmaniasis).

What do I need to tell my doctor BEFORE I take Impavido?

  • If you have an allergy to miltefosine or any other part of Impavido (miltefosine).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you are breast-feeding. Do not breast-feed while you take Impavido (miltefosine) and for 5 months after you stop taking it.
  • If you have a health problem called Sjogren-Larsson-Syndrome.

This is not a list of all drugs or health problems that interact with Impavido (miltefosine).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Impavido (miltefosine) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Impavido?

  • Tell all of your health care providers that you take Impavido (miltefosine). This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This medicine caused fertility problems in animals. It is not known if it will cause fertility problems in humans. Talk with the doctor.
  • If loose stools (diarrhea) happen or you are throwing up, call your doctor. You will need to drink more fluids to keep from losing too much fluid.
  • If you throw up or have loose stools (diarrhea), birth control pills may not work as well. If you take birth control and this happens, use an extra form of birth control like condoms. Talk to your doctor.

How is this medicine (Impavido) best taken?

Use Impavido (miltefosine) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with food.
  • Swallow whole. Do not chew, break, open, or melt.
  • To gain the most benefit, do not miss doses.
  • Keep taking Impavido (miltefosine) as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Very upset stomach or throwing up.
  • Very loose stools (diarrhea).
  • Any unexplained bruising or bleeding.
  • Fever.
  • For males, testicle pain.
  • Orgasm with less or no semen.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

What are some other side effects of Impavido?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Impavido?

  • Store in the original container at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Impavido (miltefosine) is refilled. If you have any questions about Impavido (miltefosine), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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