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Cyramza

Generic Name: ramucirumab (RA-mue-SIR-ue-mab)
Brand Name: Cyramza

Cyramza increased the risk of bleeding (eg, bleeding in the stomach or bowels). This includes severe and sometimes fatal bleeding events. Call your doctor right away if you have unusual bruising or bleeding.

Cyramza may increase the risk of holes in the gastrointestinal (GI) tract. Sometimes, these can be deadly. Discuss any questions or concerns with your doctor.

Cyramza may affect how wounds heal. Tell your doctor if you have a wound that will not heal. If you need to have surgery, you may need to stop Cyramza before surgery. Start taking it again after surgery as you have been told by your doctor. Discuss any questions or concerns with your doctor.


Cyramza is used for:

Treating certain types of cancer (eg, stomach, lung, or colorectal ). It may also be used for other conditions as determined by your doctor.

Cyramza is a monoclonal antibody. It works by killing cancer cells.

Do NOT use Cyramza if:

  • you are allergic to any ingredient in Cyramza

Contact your doctor or health care provider right away if any of these apply to you.

Before using Cyramza:

Some medical conditions may interact with Cyramza. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have high blood pressure, kidney or liver problems, high urine protein levels, or thyroid problems

Some MEDICINES MAY INTERACT with Cyramza. However, no specific interactions with Cyramza are known at this time.

Ask your health care provider if Cyramza may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Cyramza:

Use Cyramza as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Cyramza will be given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
  • Your doctor may give you certain other medicines (eg, acetaminophen, antihistamines, corticosteroids) before you receive Cyramza.
  • If you miss a dose of Cyramza, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Cyramza.

Important safety information:

  • Tell your doctor or dentist that you take Cyramza before you receive any medical or dental care, emergency care, or surgery.
  • Serious and sometimes fatal blood clots, which may cause heart attack and stroke, have happened with Cyramza. Discuss any questions or concerns with your doctor.
  • Cyramza may increase the risk of high blood pressure. You will need to have your blood pressure checked while you take Cyramza.
  • A serious brain problem called reversible posterior leukoencephalopathy syndrome (RPLS) has happened with Cyramza. It can cause very bad health problems that may not go away and sometimes death. Discuss any questions or concerns with your doctor.
  • Have your urine checked as you have been told by your doctor.
  • Lab tests may be performed while you use Cyramza. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Cyramza may cause fertility problems in women. This may affect being able to have children. Discuss any questions or concerns with your doctor.
  • If you are able to become pregnant, you must use an effective form of birth control while you take Cyramza, and for at least 3 months after you stop taking it. If you have questions about effective birth control, talk with your doctor.
  • PREGNANCY and BREAST-FEEDING: Cyramza may cause harm to the fetus. Do not become pregnant while you are using it or for at least 3 months after your last dose. If you become pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Cyramza.

Possible side effects of Cyramza:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; increased amount of tears; loss of appetite; tiredness; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); back pain or spasms; burning, numbness, or tingling feeling that does not feel normal; change in balance; chest, jaw, or arm pain; chills; confusion; fainting; fast or irregular heartbeat; fever; flushing; mental or mood changes; mouth irritation or mouth sores; one-sided weakness; redness or irritation of the palms of hands or soles of feet; seizures; severe or persistent dizziness or headache; severe or persistent stomach pain, diarrhea, vomiting, or constipation; shortness of breath or other breathing problems; signs of bleeding (eg, throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; nosebleeds; vaginal bleeding that is not normal; bruises without a reason or bruises that get bigger; any bleeding that is very bad or that you cannot stop); signs of kidney problems (eg, not able to pass urine, change in how much urine passed, blood in the urine, a big weight gain); skin wound that will not heal; sluggishness; slurred speech; swelling of the hands, ankles, or feet; tremor; unusual tiredness or weakness; vision problems (eg, loss of vision).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Cyramza:

Cyramza is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.

General information:

  • If you have any questions about Cyramza, please talk with your doctor, pharmacist, or other health care provider.
  • Cyramza is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Cyramza or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Cyramza. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Cyramza. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Cyramza.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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