Generic Name: amprenavir (am-PREN-ah-veer)
Brand Name: Agenerase
Amprenavir is used for:
Treating HIV infection. Amprenavir is used in combination with other medicines.
Amprenavir is an HIV-protease inhibitor. It works by inhibiting the growth of HIV.
Do NOT use amprenavir if:
- you are allergic to any ingredient in amprenavir
- you are taking astemizole, cisapride, delavirdine, an ergot derivative (eg, ergotamine), eletriptan, erythromycin, certain HMG-CoA reductase inhibitors (lovastatin, simvastatin), midazolam, nevirapine, an oral contraceptive (birth control pills), pimozide, a quinazoline (eg, alfuzosin), rifampin, St. John's wort, sumatriptan, terfenadine, or triazolam
Contact your doctor or health care provider right away if any of these apply to you.
Before using amprenavir:
Some medical conditions may interact with amprenavir. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
- if you have diabetes, hemophilia or other bleeding disorders, high cholesterol or triglyceride levels, high blood sugar, liver disease, a skin rash, or kidney problems
Some MEDICINES MAY INTERACT with amprenavir. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Carbamazepine, dexamethasone, methadone, non-nucleoside reverse transcriptase inhibitors (NNRTIs) (eg, efavirenz, nevirapine), oral contraceptives (birth control pills), phenobarbital, phenytoin, rifampin, saquinavir, or St. John's wort because the effectiveness of amprenavir may be decreased
- HIV protease inhibitors (eg, indinavir, ritonavir) because the actions and side effects of amprenavir may be increased
- Astemizole, certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), cisapride, eletriptan, ergot derivatives (eg, ergotamine), erythromycin, midazolam, pimozide, quinazolines (eg, alfuzosin), sumatriptan, terfenadine, or triazolam because the risk of side effects may be increased by amprenavir
- Aldosterone blockers (eg, eplerenone), antiarrhythmics (eg, amiodarone, bepridil, flecainide, lidocaine, propafenone, quinidine), azole antifungals (eg, itraconazole, ketoconazole), benzodiazepines (eg, alprazolam), calcium channel blockers (eg, diltiazem, amlodipine), fluoxetine, fluticasone, immunosuppressants (eg, cyclosporine, tacrolimus), muscarinic receptor antagonists (eg, darifenacin), narcotic analgesics (eg, fentanyl), rifabutin, sildenafil, trazodone, or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects may be increased by amprenavir
- Delavirdine because effectiveness may be decreased by amprenavir
- Anticoagulants (eg, warfarin) because actions and effectiveness may be altered by amprenavir
This may not be a complete list of all interactions that may occur. Ask your health care provider if amprenavir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use amprenavir:
Use amprenavir as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Amprenavir may be taken with or without food. If you take it with food, do not take it with a high fat meal.
- Amprenavir comes with an additional patient leaflet. Read it carefully and reread it each time you get amprenavir refilled.
- Do not take antacids or a buffered form of didanosine within 1 hour before or 1 hour after taking amprenavir.
- Continue to use amprenavir even if you feel well. Do not miss any doses.
- Do not switch between the capsule and liquid forms of amprenavir. They are not equal milligram to milligram. Consult with your doctor or pharmacist.
- If you miss a dose of amprenavir, take it as soon as possible. If you miss a dose by more than 4 hours, skip the missed dose and go back to your regular dosing schedule. It is important not to miss doses of amprenavir. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use amprenavir.
Important safety information:
- Amprenavir is not a cure for HIV infection and patients may continue to acquire illnesses and infections associated with HIV. Remain under the care of your doctor.
- Amprenavir may not prevent other infections. If your health changes, check with your doctor.
- When your medicine supply begins to run low, get more from your doctor or pharmacist as soon as possible. The virus may develop resistance to amprenavir and become more difficult to treat if you stop taking it, even for a short period of time.
- Amprenavir offers no protection from the transmission of HIV to others through sexual contact or blood contamination. Use barrier forms of contraception (eg, condoms) if you are infected with HIV. Do not share needles, other injection equipment, or personal items such as toothbrushes or razor blades.
- Certain birth control pills may decrease the effectiveness of amprenavir. Women should not take birth control pills and should use additional or other birth control measures (eg, condoms, diaphragms) while taking amprenavir.
- Do not take vitamin E supplements while you are taking amprenavir. Amprenavir already contains vitamin E.
- Amprenavir may cause high blood sugar (eg, thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, fruity breath odor). If these symptoms occur, tell your doctor immediately.
- Changes in body fat may occur in some patients taking this type of medicine. These changes may include increased amount of fat in the upper back and neck, breast, and around the trunk, and loss of fat from the legs, arms, and face. The cause and long-term effects are unknown. Discuss any concerns with your doctor.
- LAB TESTS, including liver function, blood cholesterol or triglyceride levels, and white blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
- Use amprenavir with caution in the ELDERLY because they may be more sensitive to its effects.
- Amprenavir is not recommended for use in CHILDREN younger than 4 years of age. Safety and effectiveness in this age group have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using amprenavir during pregnancy. It is unknown if amprenavir is excreted in breast milk. Do not breast-feed while taking amprenavir. HIV-infected mothers should not breast-feed their infants because of the risk of transmitting the HIV infection or amprenavir.
Possible side effects of amprenavir:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea/loose stools; headache; nausea; numbness or tingling around the mouth and in the hands and feet; rash; shift of body fat to stomach and upper back; stomach pain; taste disorders; vomiting.
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in mood, emotions, or behavior; clumsiness; depression; excessive urination, thirst, or hunger; fever, chills, or sore throat; muscle pain or stiffness; red, swollen, or blistered skin; seizures; unusual tiredness or weakness; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of amprenavir:
Store amprenavir at 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep amprenavir out of the reach of children and away from pets.
- If you have any questions about amprenavir, please talk with your doctor, pharmacist, or other health care provider.
- Amprenavir is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information is a summary only. It does not contain all information about amprenavir. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about amprenavir
- Side Effects
- During Pregnancy
- Drug Interactions
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- Drug class: protease inhibitors
Other brands: Agenerase