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Generic Name: Insulin (Oral Inhalation) (IN soo lin)
Brand Name: Afrezza

Medically reviewed by Last updated on Sep 22, 2020.


  • Sudden lung problems can happen with Afrezza (insulin (oral inhalation)). Do not use Afrezza (insulin (oral inhalation)) if you have a chronic lung disease like asthma or COPD. Before using Afrezza (insulin (oral inhalation)), tell your doctor if you have ever had any lung or breathing problems.

Uses of Afrezza:

  • It is used to lower blood sugar in patients with high blood sugar (diabetes).

What do I need to tell my doctor BEFORE I take Afrezza?

  • If you have an allergy to insulin or any other part of Afrezza (insulin (oral inhalation)).
  • If you are allergic to Afrezza (insulin (oral inhalation)); any part of Afrezza (insulin (oral inhalation)); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have low blood sugar.
  • If you have or have had lung cancer.
  • If you have an acidic blood problem caused by diabetes.
  • If you smoke or have recently stopped smoking.

This is not a list of all drugs or health problems that interact with Afrezza (insulin (oral inhalation)).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Afrezza (insulin (oral inhalation)) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Afrezza?

  • Tell all of your health care providers that you take Afrezza (insulin (oral inhalation)). This includes your doctors, nurses, pharmacists, and dentists.
  • Allergic reactions have happened with Afrezza (insulin (oral inhalation)). Rarely, some reactions can be very bad or life-threatening. Talk with the doctor.
  • Low blood sugar may happen with Afrezza (insulin (oral inhalation)). Very low blood sugar can lead to seizures, passing out, long lasting brain damage, and sometimes death. Talk with the doctor.
  • Low blood potassium may happen with Afrezza (insulin (oral inhalation)). If not treated, this can lead to a heartbeat that is not normal, very bad breathing problems, and sometimes death. Talk with the doctor.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how Afrezza (insulin (oral inhalation)) affects you.
  • Some diabetes drugs like pioglitazone or rosiglitazone may cause heart failure or make it worse in people who already have it. Using insulin with these drugs may increase this risk. If you also take one of these drugs, talk with the doctor.
  • It may be harder to control blood sugar during times of stress such as fever, infection, injury, or surgery. A change in physical activity, exercise, or diet may also affect blood sugar.
  • Wear disease medical alert ID (identification).
  • Do not drive if your blood sugar has been low. There is a greater chance of you having a crash.
  • Check your blood sugar as you have been told by your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Avoid drinking alcohol or taking products that have alcohol in them while taking Afrezza (insulin (oral inhalation)).
  • Do not smoke while using Afrezza (insulin (oral inhalation)).
  • A few more cases of lung cancer happened in people taking Afrezza (insulin (oral inhalation)) compared to people taking other diabetes drugs. The cause of this is not known. If you have lung cancer or if you have any questions, talk with your doctor.
  • If you are 65 or older, use Afrezza (insulin (oral inhalation)) with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Afrezza (insulin (oral inhalation)) while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Afrezza) best taken?

Use Afrezza (insulin (oral inhalation)) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • For breathing in only by an inhaler into the lungs.
  • Only use the device that comes with Afrezza (insulin (oral inhalation)). Do not use any other devices.
  • Use at the start of a meal as your doctor has told you.
  • Put the cap back on after you are done using your dose.
  • After a cartridge has been put in, handle the device with care. If the device has been turned upside down, held with the mouthpiece pointing down, shaken, or dropped, replace the cartridge before use.
  • Follow the diet and workout plan that your doctor told you about.
  • Be sure you know what to do if you do not eat as much as normal or if you skip a meal.

What do I do if I miss a dose?

  • Be sure you know what to do if you forget to take a dose.
  • If you are not sure what to do if you miss a dose, call your doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low potassium levels like muscle pain or weakness, muscle cramps, or a heartbeat that does not feel normal.
  • Anxiety.
  • Change in eyesight.
  • Chills.
  • Dizziness or passing out.
  • Feeling very sleepy.
  • Mood changes.
  • Seizures.
  • Slurred speech.
  • Cough that does not go away.
  • Cough that goes away and comes back.
  • Wheezing.
  • Low blood sugar may occur. Signs may be dizziness, headache, feeling sleepy, feeling weak, shaking, a fast heartbeat, confusion, hunger, or sweating. Call the doctor right away if any of these signs occur. Follow what you have been told to do if low blood sugar occurs. This may include taking glucose tablets, liquid glucose, or some fruit juices.
  • Lung function has gotten worse in some people taking Afrezza (insulin (oral inhalation)). Have your lung function checked while taking Afrezza (insulin (oral inhalation)). Call your doctor right away if you have breathing problems that are new or worse after starting Afrezza (insulin (oral inhalation)).

What are some other side effects of Afrezza?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Weight gain.
  • Cough.
  • Throat pain.
  • Throat irritation.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Afrezza?

  • Follow how to store closely. Read the package insert that comes with Afrezza (insulin (oral inhalation)). If you have questions about how to store Afrezza (insulin (oral inhalation)), talk with your pharmacist.
  • Be sure you know how long you can store Afrezza (insulin (oral inhalation)) before you need to throw it away.
  • Throw away the inhaler 15 days after first use and get a new one.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Afrezza (insulin (oral inhalation)) is refilled. If you have any questions about Afrezza (insulin (oral inhalation)), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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