Generic Name: insulin regular (IN-su-lin)
Brand Name: Afrezza
Sudden lung problems can happen with Afrezza. Do not use Afrezza if you have a chronic lung disease (eg, asthma, chronic obstructive pulmonary disease [COPD]). Before using Afrezza, tell your doctor if you have ever had any lung or breathing problems.
Afrezza is used for:
Treating diabetes mellitus.
Afrezza is a fast-acting form of the hormone insulin. It works by helping your body to use sugar properly. This lowers the amount of glucose in the blood, which helps to treat diabetes.
Do NOT use Afrezza if:
- you are allergic to any ingredient in Afrezza
- you have a chronic lung disease (eg, asthma, COPD)
- you are having an episode of low blood sugar or you have an acidic blood problem caused by diabetes (diabetic ketoacidosis)
- you smoke or you have recently stopped smoking
Contact your doctor or health care provider right away if any of these apply to you.
Before using Afrezza:
Some medical conditions may interact with Afrezza. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you drink alcoholic beverages
- if you have lung or breathing problems, heart problems (eg, heart failure), or kidney or liver problems
- if you have, have ever had, or are at risk for lung cancer
- if you are using any other inhaled medicines
- if you are fasting or you do not eat regularly
Some MEDICINES MAY INTERACT with Afrezza. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Beta-blockers (eg, propranolol), clonidine, guanethidine, lithium, or reserpine because they may increase the risk of high or low blood sugar or may hide the signs and symptoms of low blood sugar, if it occurs
- Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin receptor blockers (eg, losartan), disopyramide, fibrates (eg, clofibrate, gemfibrozil), fluoxetine, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), other medicines for diabetes (eg, glipizide, metformin, nateglinide), pentamidine, pentoxifylline, pramlintide, propoxyphene, salicylates (eg, aspirin), somatostatin analogs (eg, octreotide), or sulfonamide antibiotics (eg, sulfamethoxazole) because the risk of low blood sugar may be increased
- Thiazolidinediones (eg, pioglitazone, rosiglitazone) because the risk of heart failure may be increased
- Atypical antipsychotics (eg, clozapine, olanzapine), corticosteroids (eg, prednisone), danazol, diuretics (eg, furosemide, hydrochlorothiazide), estrogen, glucagon, hormonal contraceptives (eg, birth control pills), isoniazid, niacin, phenothiazines (eg, chlorpromazine), progesterones (eg, medroxyprogesterone), protease inhibitors (eg, boceprevir, ritonavir), somatropin, sympathomimetics (eg, albuterol, epinephrine, terbutaline), or thyroid hormones (eg, levothyroxine) because they may decrease Afrezza's effectiveness, resulting in high blood sugar
This may not be a complete list of all interactions that may occur. Ask your health care provider if Afrezza may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Afrezza:
Use Afrezza as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Afrezza comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Afrezza refilled.
- Afrezza is for breathing in only by an inhaler into the lungs.
- Use Afrezza at the start of a meal, as directed by your doctor.
- Follow how to use as you have been told by your doctor or follow the instructions in the Medication Guide.
- It is very important to follow your insulin regimen exactly. Do NOT miss any doses. Ask your doctor for specific instructions to follow in case you ever miss a dose of insulin.
Ask your health care provider any questions you may have about how to use Afrezza.
Important safety information:
- Drowsiness, dizziness, light-headedness, or blurred vision may occur while you use Afrezza. These effects may be worse if you use it with alcohol or certain medicines. Use Afrezza with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol or use medicines that contain alcohol without discussing it with your doctor. Drinking alcohol may increase the risk of developing high or low blood sugar.
- Do NOT use more than the recommended dose, use Afrezza more often than prescribed, or change the type or dose of insulin you are using without checking with your doctor.
- Any change of insulin should be made cautiously and only under medical supervision. Changes in purity, strength, brand (manufacturer), type (regular, NPH, lente), species (beef, pork, beef-pork, human), and/or method of manufacture may require a change in dose.
- Illness, especially with nausea and vomiting, may cause your insulin requirements to change. Even if you are not eating, you still require insulin. You and your doctor should establish a sick-day plan to use in case of illness. When you are sick, test your blood/urine frequently and call your doctor as instructed.
- Tell your doctor or dentist that you take Afrezza before you receive any medical or dental care, emergency care, or surgery.
- Low blood potassium may happen with Afrezza. If not treated, this can lead to an irregular heartbeat, very bad breathing problems, and sometimes death. Discuss any questions or concerns with your doctor.
- Carry an ID card at all times that says you have diabetes.
- Low blood sugar levels (hypoglycemia) may happen with insulins. This is most likely to occur if you take too much insulin, skip a meal, or exercise too much. Severe low blood sugar levels can cause seizures or death. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you hungrier. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or nondiet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
- Developing a fever or infection, eating significantly more than prescribed, or missing your dose of insulin may cause high blood sugar (hyperglycemia). High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell you doctor right away.
- Proper diet, regular exercise, and regular testing of blood sugar are important for best results when using Afrezza.
- Lung function has gotten worse in some people taking Afrezza. Have your lung function checked while taking Afrezza. Call your doctor right away if you have new or worsening breathing problems after starting Afrezza.
- Lab tests may be performed while you use Afrezza. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Afrezza with caution in the ELDERLY; they may be more sensitive to its effects, especially low blood sugar. If low blood sugar occurs, it may be more difficult to recognize in elderly patients.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Afrezza while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use Afrezza, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Afrezza:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Cough; mild weight gain; throat pain or irritation.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); anxiety; changes in vision; chills; confusion; dizziness; drowsiness; fainting; fast heartbeat; headache; mood changes; persistent cough or cough that goes away and comes back; seizures; shortness of breath; slurred speech; symptoms of low blood potassium levels (eg, irregular heartbeat; muscle pain, weakness, or cramping); tremor; unusual hunger; unusual sweating; wheezing.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Afrezza:
Follow how to store closely. Read the Medication Guide that comes with this drug. If you have questions about how to store this drug, talk with your pharmacist.
- If you have any questions about Afrezza, please talk with your doctor, pharmacist, or other health care provider.
- Afrezza is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Afrezza or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Afrezza. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Afrezza. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Afrezza.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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