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Tocainide use while Breastfeeding

Drugs containing Tocainide: Tonocard

Tocainide Levels and Effects while Breastfeeding

Summary of Use during Lactation

Limited data indicate that rather large amounts of tocainide are excreted into breastmilk. Because of the relative lack of data concerning breastfeeding during maternal tocainide therapy, exclusively breastfed infants should be carefully monitored if this drug is used during lactation, possibly including measurement of serum levels to rule out toxicity if there is a concern.

Drug Levels

Maternal Levels. One woman taking tocainide 400 mg every 8 hours orally during the early postpartum period had levels of 12 mg/L at 0.5 hour before a dose and 28 mg/L at 2 hours after a dose.[1] These data indicate that an exclusively breastfed infant would receive between 9 and 21% of the maternal weight-adjusted dosage.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1. Wilson JH. Breast milk tocainide levels. J Cardiovasc Pharmacol. 1988;12:497. Letter. PMID: 2465453

Tocainide Identification

Substance Name

Tocainide

CAS Registry Number

41708-72-9

Drug Class

Antiarrhythmics

Administrative Information

LactMed Record Number

260

Last Revision Date

20130907

Disclaimer

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Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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