Tea Tree Oil use while Breastfeeding
Medically reviewed by Drugs.com. Last updated on Mar 28, 2022.
Tea Tree Oil Levels and Effects while Breastfeeding
Summary of Use during Lactation
Tea tree (Melaleuca alternifolia) oil contains primarily terpinen-4-ol, but more than 100 other constituents have been identified, including 1,8-cineole (eucalyptol). Tea tree oil should not be confused with cajeput oil, niauouli oil, kanuka oil, or manuka oil which are obtained from Melaleuca species. Tea tree oil has no specific lactation-related uses. It is usually used topically for the treatment of infections. No data exist on the excretion of any components of tea tree oil into breastmilk or on the safety and efficacy of tea tree oil in nursing mothers or infants. Topical tea tree oil is generally well tolerated, but should not be taken orally. Tea tree oil has estrogenic and antiandrogenic activity, so topical application around the breast should be avoided.
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Maternal Levels. Twelve nursing mothers who were19 weeks to 19 months postpartum ingested 100 mg of 1,8 cineole (eucalyptol) in the form of delayed-release capsules (Soledum-Klosterfrau Vertriebs GmbH, Germany) that release the drug in the intestine. Then they pumped 1 to 4 milk samples at the time they perceived the smell of eucalyptus on their breath which had been previously shown to be approximately concurrent. A total of 21 milk samples were obtained. Odor was rated by a panel of 3 to 5 experts as either smelling like eucalyptus or not. Fourteen of the samples had a distinct eucalyptus-like odor. Chemical analysis of the positive odor tests found 1,8-cineole in concentrations from 70 to about 2090 mcg/kg of milk, most in the range of 100 to 500 mcg/kg of milk. Samples with negative odor tests contained concentrations in the range of 0.98 to about 20.23 mcg/kg of milk. In one woman who donated 3 samples, the highest concentration of 71 mcg/kg occurred at 1.5 hours after ingestion, with concentrations of 1 mcg/kg before ingestion and 15 mcg/kg at 9.5 hours after ingestion.
Eight women had their milk analyzed for 1,8-cineole metabolites. Ten metabolites and several enantiomers of these metabolites were detected.[2,3]
Eighteen nursing mothers who were nursing their infants of 8 to 53 weeks of age were served a curry dish that contained an average of 394 mcg of 1,8-cineole. Baseline 1,8-cineole concentrations in milk averaged 1.44 mcg/L (range 0.07 to 7.57 mcg/L). Milk samples contained 1,8-cineole in concentrations of 0.19 to 7.41 mcg/L at 1 hour after eating, 0.33 to 7.86 mcg/L at 2 hours after eating and 0.22 to 3.33 mcg/L at 3 hours after eating.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Nursing mothers who were participating in an experiment on the excretion of 1,8-cineole (eucalyptol) in breastmilk took a 100 mg capsule of 1,8-cineole orally. Although instructed not to, 12 mothers breastfed their infants during the experiment. Mothers reported that none of their infants refused their milk or breastfed less than usual. Two mothers felt that their infants were more agitated a few hours after breastfeeding. A third mother reported that the infant stopped nursing from time to time and "looked puzzled", but resumed nursing. Upon repeating the experiment 6 weeks later, the infant did not react in an unusual way during breastfeeding.
Effects on Lactation and Breastmilk
Gynecomastia occurred in a prepubertal boy who was using a grooming product containing tea tree oil. The gynecomastia resolved after the product was discontinued. In vitro testing found that tea tree oil possesses mild estrogenic and antiandrogenic activity. The relevance of these findings has been questioned,[6-9] but no further testing has been reported to confirm or refute the findings as of the revision date.
Kirsch F, Beauchamp J, Buettner A. Time-dependent aroma changes in breast milk after oral intake of a pharmacological preparation containing 1,8-cineole. Clin Nutr. 2012;31:682–92. [PubMed: 22405404]
Kirsch F, Buettner A. Characterisation of the metabolites of 1,8-cineole transferred into human milk: Concentrations and ratio of enantiomers. Metabolites. 2013;3:47–71. [PMC free article: PMC3901259] [PubMed: 24957890]
Kirsch F, Horst K, Rohrig W, et al. Tracing metabolite profiles in human milk: Studies on the odorant 1,8-cineole transferred into breast milk after oral intake. Metabolomics. 2013;3:47–71. [CrossRef]
Debong MW, N'Diaye K, Owsienko D, et al. Dietary linalool is transferred into the milk of nursing mothers. Mol Nutr Food Res. 2021;65:e2100507. [PubMed: 34658145]
Henley DV, Lipson N, Korach KS, et al. Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med. 2007;356:479–85. [PubMed: 17267908]
Dean CJ. Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med 2007;356:2543; author reply -4. PMID: 17575591. [PubMed: 17575591]
Kurtz JL. Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med. 2007;356:2542–3. [PubMed: 17575593]
Kemper KJ, Romm AJ, Gardiner P. Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med. 2007;356:2541–2. [PubMed: 17568039]
Kalyan S. Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med. 2007;356:2542–author reply 3-4. [PubMed: 17575592]
Tea Tree Oil
CAS Registry Number
Anti-Infective Agents, Local
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