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Piperacillin and Tazobactam use while Breastfeeding

Medically reviewed on January 9, 2018.

Piperacillin and Tazobactam Levels and Effects while Breastfeeding

Summary of Use during Lactation

Limited information indicates that piperacillin produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Tazobactam has not been studied in nursing mothers. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated.

Drug Levels

Maternal Levels. No studies on the combination of piperacillin and tazobactam during breastfeeding have been reported. Piperacillin in a dosage of 4 gramsg intravenously every 8 hours for 3 or more days was given to 8 women. Milk levels were measured after 2 subsequent doses. After the first dose, milk levels ranged from 0.49 to 1.5 mg/L in the 3 hours after the dose. After the second dose, milk levels ranged from 1.1 to 1.9 mg/L in the 3 hours after the dose. Peak milk levels occurred 2 to 3 hours after the dose.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1. Baier R, Wolnik L, Puppel H et al. Piperacillin concentrations in milk and serum from lactating women. Proc ICAAC. 1982;203. Abstract 779.

Piperacillin and Tazobactam Identification

Substance Name

Piperacillin and Tazobactam

CAS Registry Number

157044-21-8

Drug Class

Antiinfective Agents

Antibacterial Agents

Penicillins

Administrative Information

LactMed Record Number

216

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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