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Montelukast use while Breastfeeding

Drugs containing Montelukast: Singulair

Montelukast Levels and Effects while Breastfeeding

Summary of Use during Lactation

Very low levels of montelukast appear in breastmilk. Montelukast is approved for use in children as young as 6 months of age and has been used in neonates in dosages far greater than the amounts in breastmilk. Amounts ingested by the infant would not be expected to cause any adverse effects in breastfed infants No special precautions are required.

Drug Levels

Maternal Levels. Seven women were given a 10 mg dose of montelukast and provide milk samples before the dose and at 6 times over the next 12 hours. Average peak milk concentration of the drug were 9.74 mcg/L at an average of 4 hours after the dose. The average milk concentration was 5.3 mcg/L which resulted in an average daily infant dosage of 0.79 mcg/kg (range 0.4 to 1.4 mcg/kg daily) or 0.68% of the weight-adjusted maternal dosage.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Beclomethasone, Cromolyn, Terbutaline, Theophylline, Zafirlukast

References

1. Datta P, Rewers-Felkins K, Baker T, Hale TW. Transfer of Montelukast into Human Milk During Lactation. Breastfeed Med. 2017;12:54-7. PMID: 28002678

Montelukast Identification

Substance Name

Montelukast

CAS Registry Number

158966-92-8

Drug Class

Anti-Asthmatic Agents

Leukotriene Antagonists

Administrative Information

LactMed Record Number

600

Last Revision Date

20170706

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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