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Dyphylline use while Breastfeeding

Medically reviewed by Last updated on Dec 22, 2023.

Drugs containing Dyphylline: Dylix, Dyline GG, Dyflex-G, Dilor, Lufyllin, Neothylline, Lufyllin-400, Dilor-400, Lufyllin-EPG, Lufyllin-GG, Show all 26 »Dilex-G, Dyphylline GG, Dyphylline GG ES, Dyphyl GG, Difil G, Difil-G Forte, Panfil G, Dy-G, Dilor-G, LGG, Dyfilin GG, D-G, Dyphyllin-GG, Dilex-G 400, Dilex-G 200, Jay-Phyl

Dyphylline Levels and Effects while Breastfeeding

Summary of Use during Lactation

Because of the relatively high levels in milk and a previous report with theophylline, occasional stimulant effects in infants should be anticipated in breastfed infants. No severe adverse reactions are expected. Amounts in milk can be minimized by avoiding breastfeeding for 3 to 4 hours after a dose.

Drug Levels

Maternal Levels. After intramuscular administration of a single 5 mg/kg dose of dyphylline, peak milk levels usually occurred between 2 and 4 hours after the dose in 20 subjects. Peak milk levels averaged 24.3 mg/L.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Albuterol, Aminophylline, Theophylline


Jarboe CH, Cook LN, Malesic I, Fleischaker J. Dyphylline elimination kinetics in lactating women: blood to milk transfer. J Clin Pharmacol. 1981;21:405-10. [PubMed: 7309903]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

  • Breast Feeding
  • Lactation
  • Anti-Asthmatic Agents
  • Bronchodilator Agents

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Further information

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