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Dyphylline use while Breastfeeding

Drugs containing Dyphylline: COPD, Dylix, Dyline GG, Dilex-G 200, Dilex-G 400, Dyphyllin-GG, D-G, Dyfilin GG, LGG, Dyflex-G, Show all 27 »Dilor-G, Dy-G, Panfil G, Difil G, Difil-G Forte, Dilor, Dyphyl GG, Dyphylline GG ES, Dyphylline GG, Dilex-G, Lufyllin-GG, Lufyllin-EPG, Dilor-400, Lufyllin-400, Neothylline, Lufyllin, Jay-Phyl

Medically reviewed on September 7, 2017

Dyphylline Levels and Effects while Breastfeeding

Summary of Use during Lactation

Because of the relatively high levels in milk and a previous report with theophylline, occasional stimulant effects in infants should be anticipated in breastfed infants. No severe adverse reactions are expected. Amounts in milk can be minimized by avoiding breastfeeding for 3 to 4 hours after a dose.

Drug Levels

Maternal Levels. After intramuscular administration of a single 5 mg/kg dose of dyphylline, peak milk levels usually occurred between 2 and 4 hours after the dose in 20 subjects. Peak milk levels averaged 24.3 mg/L.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Albuterol, Aminophylline, Theophylline


1. Jarboe CH, Cook LN, Malesic I, Fleischaker J. Dyphylline elimination kinetics in lactating women: blood to milk transfer. J Clin Pharmacol. 1981;21:405-10. PMID: 7309903

Dyphylline Identification

Substance Name


CAS Registry Number


Drug Class

Anti-Asthmatic Agents


Administrative Information

LactMed Record Number



Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.