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Study Sheds Light on Safety of Driving With Epilepsy

Posted 2 days 14 hours ago by Drugs.com

SUNDAY, Dec. 4, 2016 – People with epilepsy who experienced longer seizures during a simulated driving test may face an increased risk for crashes while on the road, a new study suggests. About 75 percent of people with epilepsy use medication to control their seizures and are able to drive. The remainder of patients typically keep a journal of seizures, noting how long they last, and doctors use that information to determine whether patients can drive safely, the study authors explained. The new study included 16 people with epilepsy who used a driving simulator for between one to 10 hours, most for an average of three to four hours. In total, the patients had 20 seizures, seven of which resulted in "crashes." The longer the seizure, the greater the chance of a "crash." Seizures lasted an average of 75 seconds among patients who crashed and 30 seconds among those who didn't crash. The ... Read more

Related support groups: Seizures, Topamax, Epilepsy, Keppra, Tegretol, Topiramate, Dilantin, Qsymia, Carbamazepine, Seizure Prevention, Levetiracetam, Phenytoin, Tegretol XR, Valproic Acid, Seizure Prophylaxis, Keppra XR, Epitol, Carbatrol, Depakene, West Syndrome

Study Questions Use of Migraine Meds in Kids, Teens

Posted 28 Oct 2016 by Drugs.com

THURSDAY, Oct. 27, 2016 – A new study raises questions about the effectiveness of medicines commonly prescribed to prevent migraines in children and teens. The 24-week clinical trial involving 328 patients found no significant differences between the drugs amitriptyline (Elavil), topiramate (Topamax) and a placebo sugar pill in reducing the number of days with a migraine or migraine-related disability. Fifty-two percent of those taking amitriptyline and 55 percent of those taking topiramate saw the number of days they had a headache drop by 50 percent or more, while 61 percent of those taking a placebo pill saw the same benefit, the findings showed. The patients taking the prescription drugs also had much higher rates of side effects, such as fatigue, dry mouth, mood changes, and tingling in the hands, arms, legs or feet. "The study was intended to demonstrate which of the commonly ... Read more

Related support groups: Migraine, Topamax, Amitriptyline, Migraine Prevention, Elavil, Topiramate, Qsymia, Migraine Prophylaxis, Endep, Amitriptyline/Chlordiazepoxide, Limbitrol, Triavil, Limbitrol DS, Topamax Sprinkle, Trokendi XR, Qudexy XR, Amitriptyline/Perphenazine, Phentermine/topiramate, Trochleitis, Vanatrip

Newer Epilepsy Drugs May Be Safer During Pregnancy

Posted 1 Sep 2016 by Drugs.com

THURSDAY, Sept. 1, 2016 – Women who take the new epilepsy drugs levetiracetam and topiramate during pregnancy don't run the risk of harming their infant's mental development, British researchers report. But the commonly prescribed anti-seizure drug valproate was linked with lower IQs in children, especially when taken at higher doses, researchers say. "The treatment of epilepsy in women who are considering a pregnancy or are pregnant involves optimizing the health of the mother as well as keeping the risk to the fetus as low as possible," said lead researcher Rebecca Bromley, a research fellow at the Institute for Human Development at the University of Manchester. In the study, children exposed to levetiracetam (Keppra) or topiramate (Topamax) in the womb did not differ from children not exposed to these drugs. And they had better outcomes than the children exposed to valproate ... Read more

Related support groups: Birth Control, Contraception, Emergency Contraception, Seizures, Topamax, Epilepsy, Keppra, Topiramate, Qsymia, Postcoital Contraception, Seizure Prevention, Levetiracetam, Vitamin/Mineral Supplementation during Pregnancy/Lactation, Keppra XR, Seizure Prophylaxis, West Syndrome, Status Epilepticus, Lennox-Gastaut Syndrome, Trokendi XR, Topamax Sprinkle

Girls Given Risky Meds Don't Get Contraceptive Advice

Posted 16 Dec 2015 by Drugs.com

WEDNESDAY, Dec. 16, 2015 – New research from a Midwestern hospital suggests a wide majority of teen girls and young women fail to get information about contraceptives when they take medications that could cause birth defects. At issue are so-called "teratogenic" medications, used for conditions ranging from acne to anxiety, that boost the risk of birth defects when taken during pregnancy. Physicians often tell sexually active women to take birth control while they're on the drugs to avoid becoming pregnant, but it's unclear whether younger females routinely get the same kind of guidance. In the new study, researchers examined the medical records of nearly 1,700 females aged 14 to 25 who received just over 4,500 prescriptions for teratogenic medications in more than 4,100 visits from 2008-2012. All the participants had visited a large, unidentified pediatric medical center in the ... Read more

Related support groups: Birth Control, Xanax, Contraception, Plan B, Klonopin, Emergency Contraception, Mirena, NuvaRing, Sprintec, Provera, Clonazepam, Nexplanon, Implanon, Depo-Provera, Ativan, Valium, Ortho Tri-Cyclen, Tri-Sprintec, Topamax, Lorazepam

Surgery May Help Teens With Frequent Migraines, Study Contends

Posted 25 Jun 2015 by Drugs.com

THURSDAY, June 25, 2015 – Migraine surgery may be an effective choice for teens who haven't gotten relief from standard treatment, a small study suggests. In the study, researchers at Case Western Reserve University School of Medicine in Cleveland reviewed the medical records of 14 patients, with an average age of 16. In teens with migraine who haven't responded well to other treatments, "migraine surgery may offer symptomatic improvement of migraine headache frequency, duration and severity in patients with identifiable anatomical trigger sites," wrote the study's authors. However, at least one headache expert questioned the value of the procedure, citing a possible placebo effect. Results of the study were published in the June issue of Plastic and Reconstructive Surgery. Migraines are recurring bouts of moderate to severe head pain, according to the U.S. National Institutes of ... Read more

Related support groups: Migraine, Topamax, Migraine Prevention, Topiramate, Qsymia, Migraine Prophylaxis, Imitrex, Sumatriptan, Treximet, Neurosurgery, Imitrex Statdose Refill, Topamax Sprinkle, Sumavel DosePro, Phentermine/topiramate, Imitrex Statdose, Topiragen, Imitrex Nasal, Naproxen/Sumatriptan, Alsuma, Zecuity

FDA Approves Expanded Indication for Qudexy XR (Topiramate) for Pediatric Patients

Posted 3 Jun 2015 by Drugs.com

Maple Grove, MN – June 1, 2015 – Upsher-Smith Laboratories, Inc. (Upsher-Smith) announced that it has received U.S. Food and Drug Administration (FDA) approval of a supplemental new drug application (sNDA) for Qudexy XR (topiramate) extended-release capsules for use as initial monotherapy in patients two years of age and older who are experiencing partial-onset seizures (POS) or primary generalized tonic-clonic seizures. Qudexy XR capsules are the only once-daily extended-release topiramate product to have received this expanded indication and to be approved for administration by sprinkling their contents onto soft food, making them a useful option for young children who may have difficulty swallowing whole capsules or tablets. Qudexy XR is a once-daily, broad-spectrum antiepileptic drug specifically engineered to deliver a smooth pharmacokinetic profile. “The expanded indication give ... Read more

Related support groups: Seizures, Topiramate

Migraine Drug May Up Risk of Eating Disorders in Some Teens

Posted 9 Apr 2015 by Drugs.com

THURSDAY, April 9, 2015 – A new report has linked a migraine medication to increased odds of eating disorders in some teens. The drug in question is called topiramate (Topamax). It's an established migraine drug for adults that was just approved for use in teens in 2014. Appetite reduction and weight loss are common side effects of the drug, according to the report authors. "For most kids, it's a great medicine, but for a handful of kids the weight loss can trigger symptoms of an eating disorder," said report author Jocelyn Lebow, a child and adolescent psychologist for the eating disorders treatment program at the University of Miami Miller School of Medicine. It's important to note that the report only showed an association between taking the drug and eating disorders; it did not prove the drug can actually cause an eating disorder. The report was published online April 6 in the ... Read more

Related support groups: Migraine, Topamax, Migraine Prevention, Topiramate, Qsymia, Eating Disorder, Migraine Prophylaxis, Topamax Sprinkle, Phentermine/topiramate, Topiragen

Topamax Approval for Migraines Expanded to Younger Users

Posted 31 Mar 2014 by Drugs.com

MONDAY, March 31, 2014 – U.S. Food and Drug Administration approval of the drug Topamax (topiramate) to prevent migraine headaches has been expanded to include adolescents 12 years to 17 years, the agency said Friday. It's the first migraine-prevention drug approved for adolescents, the FDA said in a news release. Topamax was first sanctioned in 1996 to prevent seizures, and was approved to prevent migraines in adults in 2004. Some 12 percent of the U.S. population has migraines, usually characterized by throbbing pain on one side of the head. Other symptoms may include nausea and sensitivity to light and sound. Topamax was evaluated in clinical studies involving 103 adolescent migraine sufferers. The most common side effects included burning or prickling sensations in the extremities, upper respiratory infection, loss of appetite and abdominal pain. The drug increases the risk of ... Read more

Related support groups: Migraine, Topamax, Migraine Prevention, Topiramate, Migraine Prophylaxis, Topamax Sprinkle, Topiragen

FDA Approves Topamax for Migraine Prevention in Adolescents

Posted 28 Mar 2014 by Drugs.com

March 28, 2014 – Today, the U.S. Food and Drug Administration approved Topamax (topiramate) for prevention (prophylaxis) of migraine headaches in adolescents ages 12 to 17. This is the first FDA approval of a drug for migraine prevention in this age group. The medication is taken on a daily basis to reduce the frequency of migraine headaches. Topamax was first approved by the FDA in 1996 to prevent seizures. It was approved for migraine prevention in adults in 2004. “Migraine headaches can impact school performance, social interactions, and family life,” said Eric Bastings, M.D., deputy director of the Division of Neurology Products in the FDA’s Center for Drug Evaluation and Research. “Adding dosing and safety information for the adolescent age group to the drug’s prescribing information will help to inform health care professionals and patients in making treatment choices.” Abou ... Read more

Related support groups: Migraine, Topamax, Migraine Prevention, Topiramate, Migraine Prophylaxis

Upsher-Smith Receives FDA Approval for Qudexy XR (topiramate) Extended-Release Capsules

Posted 13 Mar 2014 by Drugs.com

Maple Grove, MN – March 12, 2014 – Upsher-Smith Laboratories, Inc. (Upsher-Smith), today announced it received approval on March 11, 2014 from the U.S. Food and Drug Administration (FDA) for Qudexy XR (topiramate) extended-release capsules, a once-daily, broad-spectrum antiepileptic drug specifically engineered to deliver a smooth pharmacokinetic (PK) profile. Qudexy XR is indicated as initial monotherapy in patients 10 years of age and older with partial-onset seizures (POS) or primary generalized tonic clonic seizures. It is also approved as adjunctive therapy in patients 2 years of age and older with POS, primary generalized tonic-clonic seizures and seizures associated with Lennox-Gastaut syndrome. Qudexy XR will be available to patients in the second quarter of 2014. As many as two out of three patients treated for epilepsy have seizures that are refractory to therapy, either bec ... Read more

Related support groups: Seizures, Topiramate

Drug Might Help Heavy Drinkers Limit Their Booze

Posted 19 Feb 2014 by Drugs.com

WEDNESDAY, Feb. 19, 2014 – An anti-epilepsy drug might help problem drinkers reduce their alcohol consumption, according to new research. The study of the drug topiramate (Topamax) included 138 heavy drinkers who were divided into two groups. About half took Topamax for 12 weeks at a maximum dose of 200 milligrams a day, while the other half took an inactive placebo. Both groups of patients underwent brief counseling to help them reduce their drinking. By the end of the study period, patients in the placebo group were five times more likely to have had a heavy drinking day than those in the treatment group. In addition, more than twice as many patients in the Topamax group had no heavy drinking days during the last four weeks of the study compared to the placebo group. The patients in the treatment group also had more days without any drinking compared to those in the placebo group, ... Read more

Related support groups: Topamax, Topiramate, Alcoholism, Topamax Sprinkle, Topiragen

Epilepsy Drugs in Pregnancy May Affect Infants' Fine Motor Skills

Posted 25 Sep 2013 by Drugs.com

WEDNESDAY, Sept. 25 – Young children exposed to epilepsy drugs in the womb are at increased risk of having impaired fine motor skills, according to a new study. Exposure to the drugs in breast milk, however, does not appear to pose a threat. Researchers looked at data collected from Norwegian mothers about their children's language, behavior, and motor and social skills at the ages of 6 months, 18 months and 36 months. The women also provided information on breast-feeding during the first year for the study, which was published online Sept. 23 in the journal JAMA Neurology. Of the children in the study, 223 were exposed to one or more epilepsy drugs in the womb. At age 6 months, 11.5 percent of infants whose mothers took epilepsy drugs during pregnancy had impaired fine motor skills (which involve small muscle movements) compared with less than 5 percent of those who were not exposed ... Read more

Related support groups: Klonopin, Seizures, Clonazepam, Ativan, Valium, Lyrica, Lamictal, Topamax, Lorazepam, Depakote, Epilepsy, Diazepam, Keppra, Lamotrigine, Tegretol, Topiramate, Dilantin, Trileptal, Pregabalin, Carbamazepine

Supernus Announces Final FDA Approval and Upcoming Launch of Trokendi XR

Posted 19 Aug 2013 by Drugs.com

ROCKVILLE, Md., Aug. 19, 2013 (GLOBE NEWSWIRE) – Supernus Pharmaceuticals, Inc., a specialty pharmaceutical company, received final approval from the Food & Drug Administration (the "FDA") for Trokendi XR, a novel once-daily extended release formulation of topiramate for the treatment of epilepsy. The company expects to launch the product and for it to be available in pharmacies over the next few weeks. The approval letter states that the FDA has completed its review of the application and that Trokendi XR is approved effective August 16, 2013 for use as recommended in the agreed-upon labeling. The FDA granted a waiver for certain pediatric study requirements and a deferral for submission of post-marketing pediatric pharmacokinetic assessments that are due in 2019 followed by clinical assessments in 2025. "We are very excited about the approval of Trokendi XR and its upcoming launch. ... Read more

Related support groups: Epilepsy, Topiramate

No Proof Drugs Ease Kids' Migraines: Study

Posted 28 Jan 2013 by Drugs.com

MONDAY, Jan. 28 – Children and teens who get migraine headaches suffer in multiple ways, missing school and fun time with friends while waiting for the debilitating pain to subside. Now, two new broad reviews of pediatric migraine research point to a troubling conclusion: There is no clear evidence that drugs currently used to treat and prevent headaches among adults do anything much to help similarly afflicted children. The finding stems from a pediatric migraine-treatment investigation conducted by the U.S. Food and Drug Administration (FDA) and a pediatric migraine-prevention study out of the Medical College of Wisconsin in Milwaukee. The results of both analyses are published online Jan. 28 in JAMA Pediatrics. On the migraine prevention front, Wisconsin's Dr. Jeffrey Jackson, a professor of medicine, and colleagues reviewed 21 previously conducted studies (dating up to mid-2012) ... Read more

Related support groups: Migraine, Trazodone, Topamax, Topiramate, Oleptro, Topamax Sprinkle, Desyrel, Topiragen, Desyrel Dividose

Two New Weight-Loss Drugs Won't Reverse U.S. Obesity Crisis

Posted 19 Jul 2012 by Drugs.com

THURSDAY, July 19 – The U.S. Food and Drug Administration's approval of two new weight-loss drugs within the past month – the first such medications in 13 years – won't be a panacea for America's obesity epidemic, health professionals say. And as the FDA's drug regulators reiterated when approving the two drugs, Qysmia and Belviq, no weight-loss medication should be used without also making lifestyle changes to facilitate weight loss. "The bottom line is there's no such thing as a magic pill and I hope that individuals do not think by taking this pill that it will ensure long-term weight loss," said Keri Gans, a registered dietitian in New York City. "We need to be reminded that diet and exercise are still critical." Qysmia, formerly called Qnexa, was approved on Tuesday and is a combination of the weight-loss drug phentermine (brand name Adipex-P, among others) and the anti-seizure ... Read more

Related support groups: Obesity, Phentermine, Topamax, Belviq, Adipex-P, Topiramate, Fastin, Lorcaserin, Ionamin, T-Diet, Topamax Sprinkle, Phentermine/topiramate, Suprenza, Teramine, Panshape M, Topiragen, Phentride, Zantryl, Pro-Fast SA, Obephen

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