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Can Your Heartburn Meds Shorten Your Life?

Posted 17 days ago by Drugs.com

MONDAY, July 3, 2017 – Popular heartburn medications like Nexium, Prilosec or Prevacid may increase your risk of early death when taken for extended periods, a new study suggests. Further, the longer you take these drugs, known as proton pump inhibitors (PPIs), the greater your risk of early death, said senior researcher Dr. Ziyad Al-Aly. He is a kidney specialist and assistant professor of medicine with the Washington University School of Medicine, in St. Louis. "There was a relationship between duration of use and risk of death," Al-Aly said. "More prolonged use was associated with even higher risk." That said, Al-Aly pointed out that some patients really do need to take PPIs to deal with medical issues, even long-term. "Proton pump inhibitors actually save lives," Al-Aly said. "We don't want to leave people with a scary message. If you need this drug and you're under guidance of a ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Pantoprazole, Protonix, Indigestion, Lansoprazole, Dexilant, Prevacid, Gastrointestinal Disorders, Barrett's Esophagus, Aciphex, Duodenitis/Gastritis, Esomeprazole, Rabeprazole, Zegerid, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole

Popular Heartburn Meds Don't Raise Alzheimer's Risk: Study

Posted 28 Jun 2017 by Drugs.com

WEDNESDAY, June 28, 2017 – Drugs used to treat acid reflux and ulcers don't appear to boost the risk of dementia, as has been previously suspected, new research suggests. The study focused on widely used proton pump inhibitors (PPIs) drugs – medicines such as Prevacid, Prilosec and Nexium. Previous studies have suggested the drugs may increase the risk of dementia and Alzheimer's disease in people aged 75 and older. PPIs are used to treat digestive problems like reflux disease by reducing the body's production of acid. Researchers from Emory University in Atlanta analyzed a National Alzheimer's Coordinating Center database for the study. The data, compiled from 2005 to 2015, included close to 10,500 Americans, aged 50 or older, with normal brain function or mild thinking difficulties. Eight percent always used PPIs, and 18 percent sometimes did. Users were older than non-users. ... Read more

Related support groups: GERD, Omeprazole, Nexium, Dementia, Prilosec, Pantoprazole, Protonix, Indigestion, Alzheimer's Disease, Stomach Ulcer, Dexilant, Lansoprazole, Prevacid, Barrett's Esophagus, Gastric Ulcer, Aciphex, Duodenitis/Gastritis, Esomeprazole, Prevpac, Rabeprazole

Study Suggests Heartburn Meds-Superbug Infections Link

Posted 27 Mar 2017 by Drugs.com

MONDAY, March 27, 2017 – Patients who take certain heartburn medications may be more likely to suffer recurrent bouts of a common "superbug" infection, a new study suggests. Proton pump inhibitors, such as Prilosec, Prevacid and Nexium, or so-called H2 blockers, such as Zantac, Pepcid and Tagamet, were linked to a 50 percent increased risk of developing multiple Clostridium difficile infections, researchers found. However, the study did not prove these heartburn medications cause recurrent C. difficile infections, just that an association appears to exist. And one specialist not involved with the study said the findings won't make him change his prescribing patterns. C. difficile can cause diarrhea and life-threatening inflammation of the colon. In the United States, about half a million people get sick from C. difficile each year. In recent years, these infections have become more ... Read more

Related support groups: Infections, GERD, Bacterial Infection, Omeprazole, Nexium, Prilosec, Zantac, Pantoprazole, Protonix, Ranitidine, Dexilant, Lansoprazole, Prevacid, Pepcid, Barrett's Esophagus, Aciphex, Famotidine, Heartburn Relief, Esomeprazole, Rabeprazole

Are Heartburn Meds During Pregnancy Linked to Asthma in Kids?

Posted 9 Jan 2017 by Drugs.com

MONDAY, Jan. 9, 2017 – Women who take certain heartburn medications during pregnancy may have a child at increased risk of developing asthma, new research suggests. For the new study, investigators analyzed eight studies that included more than 1.3 million children. The researchers found that kids born to mothers who were prescribed drugs for acid reflux during pregnancy were at least one-third more likely to have been seen by a doctor for asthma symptoms. Some of the medications come from drug classes that include Tagamet, Zantac, Prilosec, Nexium and Pepcid. "Our study reports an association between the onset of asthma in children and their mothers' use of acid-suppressing medication during pregnancy," said researcher Dr. Aziz Sheikh. He's co-director of the Asthma UK Center for Applied Research, at the University of Edinburgh in Scotland. "It is important to stress that this ... Read more

Related support groups: GERD, Asthma, Omeprazole, Nexium, Prilosec, Asthma - Maintenance, Pantoprazole, Zantac, Protonix, Indigestion, Ranitidine, Lansoprazole, Dexilant, Prevacid, Pepcid, Delivery, Asthma - Acute, Aciphex, Duodenitis/Gastritis, Famotidine

Heartburn Drugs May Raise Risk of Stomach Infections: Study

Posted 5 Jan 2017 by Drugs.com

THURSDAY, Jan. 5, 2017 – People who take heartburn drugs such as Prilosec and Nexium may be at increased risk of two potentially serious gut infections, a new study suggests. The study, of nearly 565,000 adults, found those on certain heartburn drugs had higher risks of infection with C. difficile and Campylobacter bacteria. Both bugs cause abdominal pain and diarrhea, but can become more serious – especially C. diff. According to the U.S. Centers for Disease Control and Prevention, almost half a million Americans were sickened by the infection in 2011, and 29,000 of them died within a month. The heartburn drugs in question included both proton pump inhibitors (PPIs) – brands like Prilosec, Prevacid and Nexium – and H2 blockers, such as Zantac, Pepcid and Tagamet, the study authors said. All suppress stomach acid production, and the researchers suspect that may make some people more ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Zantac, Pantoprazole, Protonix, Indigestion, Ranitidine, Lansoprazole, Dexilant, Prevacid, Pepcid, Aciphex, Duodenitis/Gastritis, Famotidine, Heartburn Relief, Esomeprazole, Rabeprazole, Zantac 150

Could Common Heartburn Drugs Up Stroke Risk?

Posted 15 Nov 2016 by Drugs.com

TUESDAY, Nov. 15, 2016 – A popular category of heartburn medications – including Nexium, Prevacid, Prilosec and Protonix – may increase your risk of stroke, a new study suggests. Known as proton pump inhibitors (PPIs), these drugs increased people's overall stroke risk by 21 percent, said study lead author Dr. Thomas Sehested. However, the risk appears to be driven by people who take high doses, added Sehested, research director at the Danish Heart Foundation in Copenhagen. "People treated with a low dose of PPIs did not have a high risk of stroke," he said. "Those treated with the highest doses of PPIs had the highest risk of stroke." The extent of risk also depends on the specific PPI taken. At the highest dose, stroke risk ranged from 30 percent for lansoprazole (Prevacid) to 94 percent for pantoprazole (Protonix), the researchers said. Takeda Pharmaceutical, the maker of ... Read more

Related support groups: GERD, Heart Disease, Ischemic Stroke, Omeprazole, Nexium, Dementia, Prilosec, Zantac, Pantoprazole, Protonix, Indigestion, Alzheimer's Disease, Ranitidine, Lansoprazole, Dexilant, Prevacid, Transient Ischemic Attack, Pepcid, Barrett's Esophagus, Aciphex

Health Tip: Is it Indigestion?

Posted 6 Jun 2016 by Drugs.com

-- If you've eaten too much or indulged in a food that's greasy, fatty or spicy, you may have an uncomfortable feeling known as indigestion. Here are common symptoms, courtesy of the Cleveland Clinic: A burning sensation in the stomach or upper abdomen. An acidic taste in the mouth. Pain in the abdomen. Occasional diarrhea. Bloatedness or gassiness. Vomiting or nausea. Growling stomach. Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Zantac, Pantoprazole, Protonix, Indigestion, Ranitidine, Lansoprazole, Dexilant, Prevacid, Pepcid, Tums, Milk of Magnesia, Aciphex, Caltrate, Duodenitis/Gastritis, Famotidine, Heartburn Relief

Clues to How Popular Heartburn Drug Might Harm Arteries

Posted 10 May 2016 by Drugs.com

TUESDAY, May 10, 2016 – A popular over-the-counter heartburn medication accelerated aging of blood vessel cells in lab tests, raising red flags about its long-term effect on heart health, researchers say. Faster aging of blood vessel cells exposed to the antacid Nexium (esomeprazole) might potentially hinder the tasks these cells perform to prevent heart attack and stroke, the new study suggests. These lab results could explain why other studies have shown increased risk of heart disease in people who use proton pump inhibitors (PPIs) – the class of heartburn medication that includes Nexium, said study senior author Dr. John Cooke. "Our finding that the lining of blood vessels is impaired by proton pump inhibitors is a unifying mechanism for the reports that PPI users are at increased risk for heart attack, stroke and renal failure," said Cooke, chair of cardiovascular sciences at the ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Pantoprazole, Protonix, Indigestion, Lansoprazole, Dexilant, Prevacid, Tums, Milk of Magnesia, Aciphex, Caltrate, Duodenitis/Gastritis, Esomeprazole, Rabeprazole, Vimovo, Calcium Carbonate, Zegerid

1 in 4 Hospitalized Newborns Gets Heartburn Drugs, Despite Risks

Posted 27 Apr 2016 by Drugs.com

WEDNESDAY, April 27, 2016 – Despite reported risks, nearly one in four infants in neonatal intensive care units (NICUs) are given stomach acid-suppressing drugs, researchers report. However, they noted that the use of these medications has started to decline some in recent years. A number of studies have linked the use of stomach acid-suppressing drugs in hospitalized high-risk infants with infections, necrotizing enterocolitis (a serious disease where intestinal tissue begins to die off) and increased risk of death, the researchers said. These drugs include histamine-2 receptor antagonists such as ranitidine (Zantac), and proton pump inhibitors such as esomeprazole (Nexium). Researchers at Nationwide Children's Hospital in Columbus, Ohio, analyzed data from 43 children's hospitals across the United States from 2006 to 2013. They found that nearly 24 percent of roughly 122,000 newborns ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Zantac, Pantoprazole, Protonix, Ranitidine, Lansoprazole, Dexilant, Prevacid, Pepcid, Delivery, Aciphex, Famotidine, Heartburn Relief, Esomeprazole, Rabeprazole, Vimovo, Zantac 150, Zegerid

Common Heartburn Drugs Linked to Kidney Disease in Study

Posted 15 Apr 2016 by Drugs.com

THURSDAY, April 14, 2016 – People who use certain drugs for chronic heartburn may be at increased risk of developing kidney disease, a new study suggests. The research is the latest to highlight potential risks from drugs called proton pump inhibitors (PPIs). PPIs include prescription and over-the-counter drugs, such as Prilosec, Prevacid and Nexium. But prolonged use of PPIs has been linked to certain nutrient deficiencies and bone-density loss. According to the U.S. Food and Drug Administration, bone fractures are considered a safety concern when people use PPIs for a year or more. More recently, research has hinted at additional hazards. Last year, for example, a study tied the medications to a slight increase in heart attack risk. However, neither that study nor this new one prove that PPIs are directly to blame for these problems. "I cannot say for certain that this is ... Read more

Related support groups: GERD, Omeprazole, Prilosec, Pantoprazole, Protonix, Renal Failure, Barrett's Esophagus, Chronic Kidney Disease, Zegerid, Prilosec OTC, Zegerid OTC, Omeclamox-Pak, Omeprazole/Sodium Bicarbonate/Magnesium Hydroxide, Protonix IV, Omeprazole/Sodium Bicarbonate, Renal and Genitourinary Disorders, Omesec, Amoxicillin/clarithromycin/omeprazole

Doctors Often Overestimate Promise of Newly Approved Drugs

Posted 12 Apr 2016 by Drugs.com

TUESDAY, April 12, 2016 – Use of the word "breakthrough" in the U.S. Food and Drug Administration's expedited approval process could mislead doctors about the new drugs' actual benefits, researchers warn. The U.S. Congress in 2012 gave FDA the power to designate a drug as a "breakthrough therapy" if preliminary clinical evidence suggests an advantage over existing medications. But a survey of nearly 700 doctors revealed that many tended to misinterpret "breakthrough." Doctors often believed the drugs were supported by stronger evidence than the law requires to achieve that designation, said lead author Dr. Aaron Kesselheim. He is a faculty member at Brigham and Women's Hospital in Boston. "When people hear 'breakthrough,' it gives them an inappropriately elevated sense of what the drug might do," Kesselheim said. "It may give physicians false reassurance about the outcomes they might ... Read more

Related support groups: Nexium, Prilosec, Diagnosis and Investigation

Widely Used Heartburn Drugs Linked to Dementia Risk in Study

Posted 15 Feb 2016 by Drugs.com

MONDAY, Feb. 15, 2016 – A popular class of heartburn medications might raise a senior's risk of dementia, a new study suggests. Called proton pump inhibitors (PPIs), this group of drugs includes Prilosec, Nexium and Prevacid. They work by lowering the amount of acid produced by the stomach. But German researchers found that people 75 or older who regularly take the medications had a 44 percent increased risk of dementia, compared with seniors not using the drugs. The study only found an association, however, and not a cause-and-effect link. "To evaluate cause-and-effect relationships between long-term PPI use and possible effects on cognition in the elderly, randomized, prospective clinical trials are needed," said corresponding author Britta Haenisch, from the German Center for Neurodegenerative Diseases in Bonn. In the meantime, "Clinicians should follow guidelines for PPI ... Read more

Related support groups: GERD, Gas, Omeprazole, Nexium, Dementia, Prilosec, Pantoprazole, Protonix, Indigestion, Alzheimer's Disease, Stomach Ulcer, Dexilant, Lansoprazole, Prevacid, Gastric Ulcer, Aciphex, Peptic Ulcer, Duodenitis/Gastritis, Prevpac, Esomeprazole

Could a Lung Cancer Drug Work Better With Coke?

Posted 13 Feb 2016 by Drugs.com

FRIDAY, Feb. 12, 2016 – Patients with the leading form of lung cancer may be able to look to Coca-Cola Classic to solve a common medicinal challenge, new research suggests. As the Dutch scientists explain it, the effectiveness of the powerful lung cancer drug Tarceva (erlotinib) depends on the pH level of the stomach. But many people on Tarceva must also take a proton pump inhibitor heartburn medication – such as Nexium or Prilosec – which raises stomach pH to more alkaline levels. That higher pH can lower the absorption rate for Tarceva, cutting its effectiveness in fighting non-small-cell lung cancer, research suggests. One prior study involving healthy volunteers found the use of Prilosec lowered blood concentrations of Tarceva by 61 percent. What to do? In the new study, researchers led by Dr. Roelof van Leeuwen, of Erasmus MC Cancer Institute in Rotterdam, the Netherlands, ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Pantoprazole, Protonix, Non-Small Cell Lung Cancer, Tarceva, Tasigna, Sprycel, Esomeprazole, Prilosec OTC, Iressa, Nilotinib, Dasatinib, Erlotinib, Gefitinib, Protonix IV, Nexium 24HR, Omesec, Nexium IV

Heartburn Meds Linked to Chronic Kidney Disease

Posted 11 Jan 2016 by Drugs.com

MONDAY, Jan. 11, 2016 – A type of heartburn medication called proton pump inhibitors may be linked to long-term kidney damage, a new study suggests. Prilosec, Nexium and Prevacid belong to this class of drugs, which treat heartburn and acid reflux by lowering the amount of acid produced by the stomach. People who use proton pump inhibitors (PPIs) have a 20 percent to 50 percent higher risk of chronic kidney disease compared with nonusers, said lead author Dr. Morgan Grams, an assistant professor of epidemiology at Johns Hopkins University in Baltimore. The study was published Jan. 11 in JAMA Internal Medicine. The study doesn't establish a direct cause-and-effect relationship between the drugs and chronic kidney disease. However, Grams said, "We found there was an increasing risk associated with an increasing dose. That suggests that perhaps this observed effect is real." Proton pump ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Pantoprazole, Protonix, Renal Failure, Dexilant, Lansoprazole, Prevacid, Chronic Kidney Disease, Aciphex, Esomeprazole, Rabeprazole, Zegerid, Prilosec OTC, Dexlansoprazole, Prevacid SoluTab, Kapidex, Zegerid OTC

Chronic Heartburn Drugs Tied to Higher Risk of Kidney Disease

Posted 27 Oct 2015 by Drugs.com

TUESDAY, Oct. 27, 2015 – A common type of heartburn medication called proton pump inhibitors (PPIs) seem to be linked with increased risk of chronic kidney disease, two new studies suggest. Prilosec, Nexium and Prevacid belong to this class of drugs, which treat heartburn and acid reflux by lowering the amount of acid produced by the stomach. While the current studies have shown an association between these drugs and the development of chronic kidney disease, they did not prove a cause-and-effect relationship. Still, the lead author of one of the studies believes, "It is very reasonable to assume that PPIs themselves can cause chronic kidney disease," said Dr. Pradeep Arora, a nephrologist and associate professor at the SUNY Buffalo School of Medicine and Biomedical Science in Buffalo, N.Y. "Patients should only use PPIs for [U.S. Food and Drug Administration]-approved indications, and ... Read more

Related support groups: High Blood Pressure, Diabetes, Type 2, GERD, Hypertension, Omeprazole, Nexium, Prilosec, Pantoprazole, Protonix, Indigestion, Renal Failure, Lansoprazole, Dexilant, Prevacid, Chronic Kidney Disease, Aciphex, Duodenitis/Gastritis, Esomeprazole, Rabeprazole, Zegerid

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