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Pancreatitis News

Losing Pancreas Fat May Treat Type 2 Diabetes

Posted 25 Dec 2015 by Drugs.com

THURSDAY, Dec. 24, 2015 – British researchers say that losing 1 gram of fat from the pancreas can reverse type 2 diabetes. The catch? No one has yet figured out how to lose weight just from the pancreas. And, this small study's findings suggest that to lose that much fat from the pancreas, someone with type 2 diabetes would need to have weight-loss surgery, or diet long enough to lose about 15 percent of their body weight. While the study doesn't promise a quick fix for type 2 diabetes, it does add to the understanding of the disease, according to the study authors. "In people with type 2 diabetes, weight loss over eight weeks [after weight-loss surgery] caused pancreas fat to decrease and insulin production to normalize. But in people with normal sugar control, exactly the same weight loss caused no change in pancreas fat," said Dr. Roy Taylor, a professor of medicine and metabolism ... Read more

Related support groups: Diabetes, Type 2, Pancreatitis, Chronic Pancreatitis

Urine Test Might Find Pancreatic Cancer Early, Study Suggests

Posted 3 Aug 2015 by Drugs.com

MONDAY, Aug. 3, 2015 – Scientists report that they have developed a urine test that may detect pancreatic cancer at an early stage. Usually, symptoms of this deadly disease do not appear until it is at an advanced stage and has spread, and little can be done to save the patient. Researchers have been looking for a way to screen people for pancreatic cancer in the hopes that early detection might lead to effective treatment. "If this test proves to be as good as we hope, we could make an important difference and enable early diagnosis of pancreatic cancer completely noninvasively, using urine samples," said lead researcher Dr. Tatjana Crnogorac-Jurcevic, a reader in cancer genomics at the Centre for Molecular Oncology at Barts Cancer Institute of Queen Mary University of London. The team found three indicators ("markers") that, when combined, signal the beginnings of pancreatic cancer. ... Read more

Related support groups: Cancer, Pancreatitis, Chronic Pancreatitis, Pancreatic Cancer, Diagnosis and Investigation, Pancreatic Secretion

Study Sees No Evidence Linking Diabetes Drugs With Pancreatic Cancer

Posted 26 Feb 2014 by Drugs.com

WEDNESDAY, Feb. 26, 2014 – There's no firm evidence that the type 2 diabetes medications known as incretin-based drugs cause pancreatitis or pancreatic cancer, U.S. and European health officials say. But it's too early to say there's definitely no link between the injectable drugs and pancreatitis or pancreatic cancer, according to the safety assessment by the U.S. Food and Drug Administration (FDA) and its counterpart overseas, the European Medicines Agency (EMA). "Both agencies agree that assertions concerning a causal association between incretin-based drugs and pancreatitis or pancreatic cancer, as expressed recently in the scientific literature and in the media, are inconsistent with the current data," states the report in the Feb. 27 issue of the New England Journal of Medicine. "The FDA and the EMA have not reached a final conclusion at this time regarding such a causal ... Read more

Related support groups: Victoza, Januvia, Pancreatitis, Bydureon, Byetta, Pancreatic Cancer, Liraglutide, Onglyza, Sitagliptin, Exenatide, Saxagliptin

Newest Diabetes Drugs Linked to Higher Pancreatitis Risk

Posted 25 Feb 2013 by Drugs.com

MONDAY, Feb. 25 – Diabetes patients who take the latest class of drugs to control blood sugar levels are twice as likely to develop pancreatitis as those who take other medications to control blood sugar, according to a new study. The drugs Januvia (sitagliptin) and Byetta (exenatide) are glucagon-like peptide-1-based (GLP-1) therapies, which are used by millions of Americans with diabetes. Pancreatitis is inflammation of the pancreas, the organ that releases hormones such as insulin and glucagon, as well as enzymes that help digest food. Pancreatitis is a painful condition that can be dangerous if left untreated. People with diabetes are already at higher risk for pancreatitis because of the role the pancreas plays in the condition. In this study, researchers from Johns Hopkins University in Baltimore compared nearly 1,300 type 2 diabetes patients who took one of the GLP-1 drugs with ... Read more

Related support groups: Diabetes, Type 2, Januvia, Pancreatitis, Bydureon, Byetta, Sitagliptin, Exenatide

Gene Ups Pancreatitis Risk in Men Who Drink Heavily

Posted 13 Nov 2012 by Drugs.com

TUESDAY, Nov. 13 – Researchers have identified a genetic variant that seems to put men who are heavy drinkers at high risk of developing chronic pancreatitis. The genetic variant on the X chromosome near the claudin-2 gene was discovered during a 10-year study that included more than 2,000 people. The variant was found on the X chromosome in 26 percent of men without pancreatitis and in nearly 50 percent of men with alcoholic pancreatitis. Women have two X chromosomes and it appears that most of those with this high-risk variant on one X chromosome are protected from alcoholic pancreatitis if their other X chromosome is normal. Men, however, have an X chromosome and a Y chromosome, so they have no protection if their X chromosome has the high-risk variant. The variant on the X chromosome does not appear to cause pancreatitis, but increases the risk of chronic pancreatitis if a person ... Read more

Related support groups: Pancreatitis, Chronic Pancreatitis

Eating Vegetables May Protect Pancreas, Study Suggests

Posted 28 Jun 2012 by Drugs.com

THURSDAY, June 28 – A vegetable-heavy diet could help prevent acute pancreatitis, a new study suggests. The pancreas, which is located behind the stomach, releases digestive enzymes to break down food. Acute pancreatitis is a potentially life-threatening disease that occurs when those enzymes begin to eat the pancreas itself. For the study, researchers at the Karolinska Institute in Stockholm, Sweden, examined 80,000 Swedish adults for 11 years after they answered questions about their diets in 1997. The goal of the research was to gain a better understanding of a possible connection between antioxidant levels, which are affected by diet, and an increased risk of acute pancreatitis. Over the 11 years, 320 participants developed cases of acute pancreatitis that weren't connected to gallstones, which are a common cause of the disease. On average, those surveyed ate almost two servings of ... Read more

Related support groups: Pancreatitis

Drug May Prevent Pancreatitis After Digestive Procedure

Posted 11 Apr 2012 by Drugs.com

WEDNESDAY, April 11 – A simple anti-inflammatory drug significantly cuts the risk of painful pancreatitis after patients undergo a specialized scope exam of the digestive tract, a new study suggests. Researchers found that a single dose of indomethacin administered rectally after the procedure – known as ERCP (endoscopic retrograde cholangiopancreatography) – slashed the incidence of pancreatitis to 9.2 percent, compared with 16.9 percent in patients who received a placebo. It also reduced the severity of post-ERCP infection. Of the 602 patients studied, moderate-to-severe pancreatitis developed in only 4.4 percent of the indomethacin group, compared with 8.8 percent among placebo patients. "This is a very specific type of pancreatitis that occurs as a result of the ERCP, which is done an estimated 500,000 times annually," said study author Dr. B. Joseph Elmunzer, an assistant ... Read more

Related support groups: Pancreatitis, Indomethacin, Indocin, Indocin IV, Indocin SR

Endoscopy May Be Better Than Surgery for Severe Pancreatic Infection

Posted 13 Mar 2012 by Drugs.com

TUESDAY, March 13 – Patients with infected severe pancreatitis fare better if they undergo a less invasive endoscopic procedure rather than surgery, a new study finds. The small, preliminary trial of 20 patients with infected necrotizing pancreatitis found that those who underwent endoscopic transgastric necrosectomy (removal of the pancreatic tissue) were less likely to die or experience major complications than those who had surgical necrosectomy. Five of the 20 patients died – 10 percent of those in the endoscopy group compared with 40 percent of those in the surgery group. All deaths were caused by multiple organ failure. Major complications occurred in 20 percent of patients in the endoscopy group and 80 percent of those in the surgery group, according to the researchers. "Acute pancreatitis is a common and potentially lethal disorder. In the United States alone, more than 50,000 ... Read more

Related support groups: Pancreatitis

Popular Diabetes Drugs May Raise Pancreatic Cancer Risk, Study Suggests

Posted 22 Sep 2011 by Drugs.com

THURSDAY, Sept. 22 – People with type 2 diabetes taking the drugs Januvia or Byetta might have an increased risk of developing pancreatitis and pancreatic cancer, a preliminary study suggests. The study also found that Byetta (exenatide) may raise the risk of thyroid cancer. Although the links aren't conclusive, they merit further investigation, the researchers noted. "We have raised concern that there may be a link, but we haven't confirmed it," said lead researcher Dr. Peter Butler, director of the Larry L. Hillblom Islet Research Center at the University of California, Los Angeles. "We need to do more work to figure out whether this is real or not." Both drugs help control blood sugar levels by encouraging production of a hormone called glucagon-like peptide 1 (GLP-1). Januvia (sitagliptin) and Byetta, an injectable drug, are a new way of treating type 2 diabetes, and they ... Read more

Related support groups: Diabetes, Type 2, Januvia, Pancreatitis, Byetta, Pancreatic Cancer

Abbott Receives FDA Approval for Creon to Include Dosing Information for Patients With Chronic Pancreatitis and Pancreatectomy

Posted 5 May 2010 by Drugs.com

ABBOTT PARK, Ill.., May 3 /PRNewswire-FirstCall/ – Abbott (NYSE:ABT) today announced that the U.S. Food and Drug Administration (FDA) approved the supplemental New Drug Application (sNDA) for CREON® (pancrelipase) Delayed-Release Capsules that now includes dosing guidance in the prescribing information specific to patients with limited production of enzymes in the pancreas (exocrine pancreatic insufficiency) due to chronic pancreatitis (CP) or removal of the pancreas (pancreatectomy). Prior to this FDA approval, dosing guidance for medications such as CREON was based on patients with cystic fibrosis.   Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack of digestive enzymes made by the pancreas. Patients with chronic pancreatitis or those who have had their pancreas removed (to manage conditions of the pancreas such as CP, pancreatic cancer or ... Read more

Related support groups: Pancreatitis, Creon 10, Creon 20, Creon 5

Study Links Smoking to Increased Risk of Pancreatitis

Posted 23 Mar 2009 by Drugs.com

MONDAY, March 23 – Smoking may increase your risk of pancreatitis, an inflammation of the pancreas that causes abdominal pain. It's believed that gallstone disease and excess alcohol consumption can cause pancreatitis. Smoking is a suspected cause of pancreas damage, but it hasn't been clear whether smoking is an independent risk factor for pancreatitis, according to background information in a study by researchers in Denmark. They analyzed about 20 years of data from 17,905 people to determine if smoking was associated with increased risk of acute or chronic pancreatitis. The researchers said that 58 percent of the 9,573 women and 68 percent of the 8,332 men were current smokers, 15 percent and 19 percent of men were ex-smokers, and 28 percent of women and 13 percent of men had never smoked. By the end of the study, 113 women and 122 men had developed acute (160 cases) or chronic (97 ... Read more

Related support groups: Pancreatitis, Chronic Pancreatitis

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