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Kidneys From Deceased Diabetics Might Ease Organ Shortage: Study

Posted 25 May 2017 by Drugs.com

THURSDAY, May 25, 2017 – Kidneys from deceased diabetic donors can save the lives of patients on the transplant wait-list, researchers say. For the study, investigators compared U.S. data from more than 8,100 recipients of kidneys from deceased diabetic donors with data from people on the kidney transplant wait-list. The patients were followed for an average of nearly nine years. People who received kidneys from diabetic donors were 9 percent less likely to die during that follow-up period than those who were still on the wait-list or were seeking a kidney from a non-diabetic donor, the study found. The people who benefited most from diabetic donor kidneys were those who were most likely to die while on the wait-list, the researchers said. But poor-quality kidneys from deceased diabetic donors did not improve survival chances, the findings showed. And people under age 40 didn't benefit ... Read more

Related support groups: Renal Transplant, Diabetes Mellitus, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Rejection Prophylaxis

A 2nd Life for Risky Kidney Transplants?

Posted 11 May 2017 by Drugs.com

THURSDAY, May 11, 2017 – Philadelphia doctors say they cleared hepatitis C infections in 10 patients who received kidneys from deceased donors who had the virus. The findings suggest hundreds more of these transplants could take place each year, thus reducing wait time for a lifesaving kidney, the doctors said. "Our pilot data demonstrate the ability to cure the contracted virus following transplantation in this patient population," said the study co-leader, Dr. David Goldberg. "If future studies are successful, this may be a viable option for patients who may otherwise never see a transplant," added Goldberg, an assistant professor of medicine and epidemiology at the University of Pennsylvania School of Medicine. In the United States, more than 97,000 people need a kidney transplant. Many must wait for five or more years, the researchers said in background notes. Kidneys from donors ... Read more

Related support groups: Hepatitis C, Renal Transplant, Organ Transplant, Kidney Transplant

Cancer Risk Rises After Childhood Organ Transplant: Study

Posted 26 Apr 2017 by Drugs.com

WEDNESDAY, April 26, 2017 – Children given an organ transplant have a substantially higher risk of developing cancer – in some cases up to 200 times higher – than the general population, a new study finds. But the individual risk of any one child getting cancer still remains very small, the study authors stressed. Overall, the U.S. National Cancer Institute (NCI) study found that the risk for cancer among children who received transplants was 19 times higher than in the general population. Non-Hodgkin's lymphoma was the cancer with a 200 times higher risk. Seventy-one percent of those who developed cancer after a pediatric organ transplant had non-Hodgkin's lymphoma, the study findings showed. "We knew going into the study that the risk of lymphoma would be very high," explained Dr. Eric Engels, the study's senior investigator. "That's been seen in much smaller studies, and it's been ... Read more

Related support groups: Cancer, Leukemia, Renal Transplant, Non-Hodgkin's Lymphoma, Organ Transplant - Rejection Prophylaxis, Viral Infection, Organ Transplant, Kidney Transplant, Organ Transplant - Rejection Reversal, Rejection Prophylaxis, Rejection Reversal

Baseball Great Rod Carew Owes His Life to NFL Player's Transplanted Organs

Posted 17 Apr 2017 by Drugs.com

MONDAY, April 17, 2017 – When Baseball Hall of Famer Rod Carew received a new heart and kidney last December, he and his family had no idea who they had to thank for the lifesaving organs. But some good sleuthing by Carew's wife and the mother of the anonymous donor unearthed a startling discovery: The organs had come from former National Football League tight end Konrad Reuland, who was only 29 when he died after suffering a brain aneurysm. Carew, 71, needed the new organs because of a massive heart attack he had in 2015, which was followed by subsequent complications. He received the new organs in an operation performed at Cedars-Sinai Medical Center in Los Angeles. After the transplant, a number of Carew's family and friends asked Carew's wife, Rhonda, if the new organs might have come from Reuland. That prompted her to begin investigating. She learned the donor was a healthy local ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Rejection Prophylaxis, Cardiothoracic Surgery

Weight, Gender Appear to Play Part in Kidney Transplant Success

Posted 31 Mar 2017 by Drugs.com

THURSDAY, March 30, 2017 – Weight and gender differences between donors and recipients can affect the success of kidney transplants, a new study says. Researchers reviewed data from more than 115,000 people in the United States who received a kidney from a deceased donor. The transplants took place between 2000 and 2014. The average follow-up time was about four years. During that time, more than 21,000 patients developed transplant failure. After accounting for other possible causes, the researchers concluded that weight was a factor in transplant failure. Specifically, if a kidney transplant recipient was more than 66 pounds heavier than the donor, there was a 28 percent higher risk of transplant failure, compared with recipients who weighed about the same as donors. The researchers also noted a difference if the donor and recipient's genders were mismatched. The risk of transplant ... Read more

Related support groups: Obesity, Renal Transplant, Organ Transplant, Kidney Transplant

Cystic Fibrosis Survival Better in Canada Than in U.S.

Posted 14 Mar 2017 by Drugs.com

MONDAY, March 13, 2017 – People with cystic fibrosis are living longer than ever, but those in Canada live nearly 10 years longer than those in the United States, a new study finds. Cystic fibrosis is a genetic disease that affects the lungs and digestive tract. It causes the production of a thick, sticky mucus that clogs the lungs. This may cause life-threatening lung infections. People with cystic fibrosis also have difficulty properly breaking down and absorbing nutrients from food, the researchers explained. Between 2009 and 2013, the average Canadian with cystic fibrosis lived to just under 51 years. In the United States, someone with the lung disorder could expect to live an average of close to 41 years, the study found. Why the difference? Although the study didn't specifically look at the reasons behind the gap, possible reasons include diet, better access to lung transplants ... Read more

Related support groups: Cystic Fibrosis, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Respiratory Tract Disease, Rejection Prophylaxis, Cystic Fibrosis with Ileus, Rejection Reversal

Kidney Transplant Survival Up Among Babies, Kids

Posted 7 Mar 2017 by Drugs.com

MONDAY, March 6, 2017 – Survival rates for children who get kidney transplants have improved significantly over the last half-century, a new study finds. "The outlook for infants and children with end-stage kidney disease was once dismal, with poor survival rates after transplant. There has been great progress in pediatric kidney transplantation, and now the patient survival rate is almost 100 percent," said the study's principal investigator, Dr. Srinath Chinnakotla. Chinnakotla is an associate professor of surgery at the University of Minnesota Masonic Children's Hospital in Minneapolis, where the study was done. Since 2002, 97 percent of children who had kidney transplants at the hospital were alive a year later. That compares to 85 percent 40 to 50 years ago, the study showed. Long-term outcomes have also improved. Only 42 percent of kids who got a new kidney between 1963 and 1983 ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Kidney Transplant, Rejection Prophylaxis

Non-English Speakers Less Likely to Be on Kidney Transplant List

Posted 9 Feb 2017 by Drugs.com

THURSDAY, Feb. 9, 2017 – Language barriers may prevent some eligible U.S. patients from receiving a kidney transplant, a new study suggests. Specifically, those who don't speak English may be less likely to complete the kidney transplant evaluation necessary for them to be placed on a waiting list for a kidney from a deceased donor. For the study, researchers analyzed data from kidney failure patients across the United States. The investigators found that patients who lived in neighborhoods where more than 20 percent of households didn't speak English were 29 percent less likely to be on a kidney transplant waiting list than those in neighborhoods where less than 1 percent of households didn't speak English. Although the study can't prove a cause-and-effect relationship, the researchers found the link between not speaking English and not being on a kidney transplant waiting list was ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Hyperphosphatemia of Renal Failure

Depression Often Untreated in Dialysis Patients

Posted 27 Jan 2017 by Drugs.com

THURSDAY, Jan. 26, 2017 – Depression is common among kidney failure patients undergoing dialysis. But efforts to get them on antidepressants often fail, a new study finds. Many patients refuse to start or modify depression treatment. And in some cases kidney specialists don't want their patients taking antidepressant medication, researchers reported. "Our study demonstrated that many patients on chronic hemodialysis have depressive symptoms but do not wish to receive aggressive treatment to alleviate these symptoms," said study co-leader Dr. Steven Weisbord. "We also noted that when patients are willing to accept treatment, renal [kidney care] providers commonly do not prescribe treatment," said Weisbord, who's with the VA Pittsburgh Healthcare System. When kidneys fail, dialysis treatment is needed to remove wastes and salt from the blood. It's often done at a hospital, dialysis ... Read more

Related support groups: Depression, Lexapro, Zoloft, Cymbalta, Effexor, Prozac, Celexa, Major Depressive Disorder, Citalopram, Paxil, Sertraline, Pristiq, Amitriptyline, Venlafaxine, Fluoxetine, Effexor XR, Mirtazapine, Escitalopram, Savella, Nortriptyline

Should a Mental Disability Keep Patients Off Organ Transplant Lists?

Posted 25 Jan 2017 by Drugs.com

WEDNESDAY, Jan. 25, 2017 – Pressure is mounting for the U.S. organ donation network to tackle one of the thorniest ethical questions it's ever faced – whether a person with intellectual disabilities should be denied access to a transplant. A bipartisan group of 30 legislators from the U.S. Congress petitioned the Department of Health and Human Services in October to "issue guidance on organ transplant discrimination with regards to persons with disabilities," according to a new opinion piece in the Jan. 26 New England Journal of Medicine. The legislators' request follows several highly publicized cases in which people with intellectual disabilities have either fought to receive a transplant or have been outright denied a place on a waiting list, said co-author Dr. Scott Halpern. He's an associate professor of medical ethics and health policy at the University of Pennsylvania's ... Read more

Related support groups: Depression, Bipolar Disorder, Major Depressive Disorder, Obsessive Compulsive Disorder, Schizophrenia, Paranoid Disorder, Mania, Schizoaffective Disorder, Borderline Personality Disorder, Psychosis, Autism, Renal Transplant, Psychiatric Disorders, Neurosis, Organ Transplant - Rejection Prophylaxis, Severe Mood Dysregulation, Body Dysmorphic Disorder, Organ Transplant, Organ Transplant - Rejection Reversal, Rejection Prophylaxis

Soft Robotic Sleeve Shows Promise for Failing Hearts

Posted 18 Jan 2017 by Drugs.com

WEDNESDAY, Jan. 18, 2017 – Scientists are reporting some early success with a "soft robotic" device aimed at treating advanced heart failure. The hope, the researchers said, is to improve upon ventricular assist devices, or VADs, that are currently used for severe heart failure. The new device has been tested only on pig hearts – so there is a long way to go yet, the study authors said. It will likely be a few years before the device could be used in humans, according to researcher Ellen Roche. She is a biomedical engineer who led the study at Harvard University. But if the device pans out, it could be used in the same way that VADs are now, said Roche. She's currently with the National University of Ireland in Galway. VADs are implantable pumps that help the heart's lower chambers send blood to the body. The devices are sometimes used to manage advanced heart failure – a chronic ... Read more

Related support groups: Lisinopril, Heart Failure, Congestive Heart Failure, Lasix, Furosemide, Ramipril, Enalapril, Benazepril, Perindopril, Left Ventricular Dysfunction, Quinapril, Zestril, Vasotec, Altace, Bumetanide, Lotensin, Accupril, Captopril, Bumex, Organ Transplant

Don't Rule Out Kidneys From Elderly Donors

Posted 16 Dec 2016 by Drugs.com

THURSDAY, Dec. 15, 2016 – Healthy kidneys from elderly donors are often rejected, but even kidneys from donors 80 and older can function for years after transplantation, Italian researchers report. The results were published online Dec. 15 in the Clinical Journal of the American Society of Nephrology. "The results of this study support the use of extended criteria donors, even donors older than 80 years, but they have to be accurately selected and managed with dedicated protocols," Dr. Luigi Biancone, of the University of Turin, said in a journal news release. Researchers analyzed results of deceased donor kidney transplants performed at the Turin University Renal Transplant Center between 2003 and 2013. They focused on almost 650 transplants from so-called "extended criteria" donors – donors older than 60 and those aged 50 to 59 with certain risk factors. After a follow-up of nearly ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Peritoneal dialysis, Organ Transplant, Kidney Transplant, Graft-versus-host disease, Rejection Prophylaxis, Hyperphosphatemia of Renal Failure

New Technique Keeps Donor Lungs Viable Longer: Study

Posted 18 Nov 2016 by Drugs.com

FRIDAY, Nov. 18, 2016 – A technique that allows lungs destined for transplants to be preserved longer works well, a new Canadian study finds. The strategy, called ex-vivo lung perfusion (EVLP), allows preservation of lungs for up to 12 hours, instead of the standard six to eight hours. "We have been using EVLP ... to assess high-risk donor lungs [less healthy] for the last decade, and almost 300 patients have benefited from this technology at our centre to date," said study author Dr. Marcelo Cypel, a thoracic surgeon at Toronto General Hospital. With standard lung transplants, "donor lungs are transported cold to the hospital where they are warmed, evaluated and then cooled again until they are transplanted into the recipient," Cypel explained. The EVLP technique, which has now become more common, allows doctors to preserve lungs for longer periods by pumping them with a solution of ... Read more

Related support groups: Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Graft-versus-host disease, Respiratory Failure

Doctors Perform 1st U.S. Living-Donor Uterine Transplant

Posted 5 Oct 2016 by Drugs.com

WEDNESDAY, Oct. 5, 2016 – A team of doctors in Dallas is "cautiously optimistic" of success in what would be the first living-donor uterine transplant in the United States. Doctors at Baylor University Medical Center said Wednesday that they performed four of the transplants in September, but only one has proven successful. "During the past three weeks since the first surgery, we performed routine follow-up testing as part of the trial protocol on all four patients," Baylor said in a statement. "In three patients, we determined after several tests the transplanted organs were not receiving viable blood flow and the uteri were removed. Those patients are now doing well and will soon be back to normal activity." However, "The fourth patient's follow-up tests currently indicate a much different result," Baylor said. "Her tests are showing good blood flow to the uterus. There are also no ... Read more

Related support groups: Birth Control, Contraception, Female Infertility, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Diagnosis and Investigation, Rejection Prophylaxis

Organ Transplants Linked to Higher Skin Cancer Risk

Posted 21 Sep 2016 by Drugs.com

WEDNESDAY, Sept. 21, 2016 – People who have an organ transplant may be more likely to develop skin cancer, new research suggests. The finding applies to all transplant patients, even those who are nonwhite and dark-skinned, according to Dr. Christina Lee Chung, an associate professor of dermatology at Drexel University in Philadelphia, and colleagues. The researchers said the risk increases over time with ongoing exposure to medications that suppress the immune system to prevent organ rejection. Total-body skin exams should be a routine part of care after transplant surgery, the study authors advised. For the study, the researchers analyzed medical records of 413 organ transplant recipients, 63 percent of whom were not white. The investigators found 19 new skin cancers in 15 of the nonwhite patients. That group included six black patients, five Asians and four Hispanics. Among the ... Read more

Related support groups: Basal Cell Carcinoma, Renal Transplant, Melanoma, Skin Cancer, Melanoma - Metastatic, Organ Transplant - Rejection Prophylaxis, Squamous Cell Carcinoma, Organ Transplant, Kidney Transplant, Graft-versus-host disease, History - Skin Cancer, Rejection Prophylaxis

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