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Are Good Kidneys Going to Waste?

Posted 7 days ago by Drugs.com

THURSDAY, Dec. 7, 2017 – Despite long waiting lists for kidney donation, a new study finds that one kidney from a deceased donor is transplanted while the other kidney is often thrown away. In the United States, about 5,000 people die each year while waiting for a kidney transplant, the researchers said. Despite the long waiting list, nearly 1 in 5 kidneys recovered from deceased donors is thrown away, a rate that has risen over the past decade. To learn more about why so many kidneys are not used, the researchers examined information on more than 88,000 deceased donors in the United States between 2000 and 2015, from whom two kidneys were harvested but only one was transplanted. Even though kidneys that were thrown away often had traits considered unappealing, the partner kidneys that were used shared many or all of the same traits, yet performed well after transplant in older ... Read more

Related support groups: Kidney Transplant, Organ Transplant

Boy's Double Hand Transplant Changed His Brain

Posted 9 days ago by Drugs.com

WEDNESDAY, Dec. 6, 2017 – Two years ago, Zion Harvey was the first child to undergo a successful double hand transplant. Now he's gaining notoriety for another milestone: the way his brain reorganized itself in response to the amputation and transplantation. Harvey, now 10, lost both hands because of a severe infection in infancy. The brain rewired itself after the amputations – but reversed those changes after he received his transplanted hands, according to his doctors at Children's Hospital of Philadelphia. "With the changes observed in his brain, which our collaborative team has been closely evaluating since his transplant two years ago, Zion is now the first child to exhibit brain mapping reorientation," said study senior author Dr. L. Scott Levin. He led the 40-member team that performed the hand transplant. Each part of the body that receives nerve sensations sends signals to a ... Read more

Related support groups: Organ Transplant, Diagnosis and Investigation

'Old' Lungs May Be Good Transplant Options

Posted 9 Nov 2017 by Drugs.com

THURSDAY, Nov. 9, 2017 – Lungs from older donors are a viable option for lung transplants and should be considered more often, a new study suggests. Survival rates for younger recipients of lung transplants from donors older than 60 are similar to those who receive lungs from younger donors, researchers found. The University of Louisville team analyzed more than 14,000 lung transplants received by people 18 and older in the United States between 2005 and 2014. About 26 percent of the recipients were 50 or younger, with 2 percent having received lungs from donors older than 60. Among those transplant recipients, five-year survival rates were similar between people who received older donor lungs and those who received younger donor lungs, the findings showed. Further analysis revealed that younger patients who received older donor lungs had much better outcomes when they'd had a double ... Read more

Related support groups: Organ Transplant - Rejection Prophylaxis, Organ Transplant, Diagnosis and Investigation, Organ Transplant - Rejection Reversal, Respiratory Tract Disease, Rejection Reversal, Rejection Prophylaxis

Limiting 'Cold Time' Could Make More Organs Available for Transplant

Posted 6 Oct 2017 by Drugs.com

THURSDAY, Oct. 5, 2017 – By improving the way certain donated organs are handled before a transplant, more organs could end up being used, new research suggests. The concern centers on organs donated following "circulatory death" (DCD). That means a patient's heart, breathing and circulation stop functioning. Most donated organs come from people who are brain dead, but their circulation is continued with machines. Organs donated by DCD must undergo a controlled cooling process (called "cold ischemia") after the organ loses its original blood supply. The organ is then re-warmed when blood supply is renewed at the time of transplant. This process leads to a heightened risk for tissue damage. But a team led by Dr. John Gill of the University of British Columbia and Vancouver's Providence Health Care found that by limiting the cooling process to a period of no more than 12 hours, DCD ... Read more

Related support groups: Renal Failure, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Peritoneal dialysis, Kidney Transplant, Organ Transplant, Organ Transplant - Rejection Reversal, Rejection Reversal, Rejection Prophylaxis, Hyperphosphatemia of Renal Failure

Donor Kidneys Rejected by Centers 7 Times on Average

Posted 27 Jul 2017 by Drugs.com

THURSDAY, July 27, 2017 – A donated kidney is turned away for transplant an average of seven times before reaching the patient who finally receives it, a new study shows. Transplant centers regularly reject kidneys based on a donor's age or perceived quality of the organ, even though these kidneys are eventually accepted and work well for people farther down the waiting list, explained lead researcher Dr. Anne Huml, a nephrologist and health disparities fellow with Case Western Reserve University in Cleveland. The centers are likely being appropriately picky in selecting organs, to ensure the greatest chance of success by carefully matching each kidney to each recipient, Huml said. "If someone's been waiting five years, why rush and take the first kidney offered when within a month they'll be offered a better kidney and their outcome will be better?" Huml said. But such hesitation can ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Kidney Transplant, Organ Transplant, Graft-versus-host disease, Rejection Prophylaxis

Researchers Grow Functioning Liver Tissue in Mice

Posted 19 Jul 2017 by Drugs.com

WEDNESDAY, July 19, 2017 – Researchers say they were able to coax tiny "seeds" of liver tissue into fully functioning livers in mice. If this approach works in people, it could help reduce long wait lists for liver transplants. It might also benefit people with failing livers who don't quality for liver transplants, according to the researchers. The scientists placed three types of liver cells – the seeds – into biodegradable tissue scaffolds. They then implanted those scaffolds in mice with damaged livers. Once inside the mice, the tiny structures grew 50-fold and were able to perform normal liver tissue functions. "There are just not enough organs to go around. Our goal is that one day we could use this technology to increase the number of transplants that are done for patients, which right now is very limited," said senior author Dr. Sangeeta Bhatia. She's a professor of health ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Kidney Transplant, Organ Transplant, Liver and Pancreatic Disease

Are Doctors Discarding Donor Kidneys That Could Save Lives?

Posted 7 Jul 2017 by Drugs.com

THURSDAY, July 6, 2017 – U.S. doctors are discarding donated kidneys that could keep people alive for years, simply because the organs are not top-quality, a new study claims. "Suboptimal" kidneys from older donors with health problems perform much better than expected, and would preserve a patient's life much longer than dialysis, said lead researcher Dr. Sumit Mohan, an assistant professor at Columbia University's Mailman School of Public Health. About 73 percent of lower-quality kidneys received by Columbia patients were still functioning five years after transplant, Mohan and his colleagues found. "To our surprise, yes, they did worse than the best-quality kidneys, but they didn't do that poorly," Mohan said. By comparison, the five-year survival rate for kidney patients on dialysis is about 35 percent, Mohan said. "If I don't get a kidney, my alternative is to stay on dialysis," ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease, Peritoneal dialysis, Kidney Transplant, Organ Transplant, Organ Transplant - Rejection Reversal, Rejection Reversal, Nephropathy, Renal and Genitourinary Disorders, Hyperphosphatemia of Renal Failure, Rejection Prophylaxis

Kidneys From Deceased Diabetics Might Ease Organ Shortage: Study

Posted 25 May 2017 by Drugs.com

THURSDAY, May 25, 2017 – Kidneys from deceased diabetic donors can save the lives of patients on the transplant wait-list, researchers say. For the study, investigators compared U.S. data from more than 8,100 recipients of kidneys from deceased diabetic donors with data from people on the kidney transplant wait-list. The patients were followed for an average of nearly nine years. People who received kidneys from diabetic donors were 9 percent less likely to die during that follow-up period than those who were still on the wait-list or were seeking a kidney from a non-diabetic donor, the study found. The people who benefited most from diabetic donor kidneys were those who were most likely to die while on the wait-list, the researchers said. But poor-quality kidneys from deceased diabetic donors did not improve survival chances, the findings showed. And people under age 40 didn't benefit ... Read more

Related support groups: Renal Transplant, Diabetes Mellitus, Organ Transplant - Rejection Prophylaxis, Kidney Transplant, Organ Transplant, Rejection Prophylaxis

A 2nd Life for Risky Kidney Transplants?

Posted 11 May 2017 by Drugs.com

THURSDAY, May 11, 2017 – Philadelphia doctors say they cleared hepatitis C infections in 10 patients who received kidneys from deceased donors who had the virus. The findings suggest hundreds more of these transplants could take place each year, thus reducing wait time for a lifesaving kidney, the doctors said. "Our pilot data demonstrate the ability to cure the contracted virus following transplantation in this patient population," said the study co-leader, Dr. David Goldberg. "If future studies are successful, this may be a viable option for patients who may otherwise never see a transplant," added Goldberg, an assistant professor of medicine and epidemiology at the University of Pennsylvania School of Medicine. In the United States, more than 97,000 people need a kidney transplant. Many must wait for five or more years, the researchers said in background notes. Kidneys from donors ... Read more

Related support groups: Hepatitis C, Renal Transplant, Kidney Transplant, Organ Transplant

Cancer Risk Rises After Childhood Organ Transplant: Study

Posted 26 Apr 2017 by Drugs.com

WEDNESDAY, April 26, 2017 – Children given an organ transplant have a substantially higher risk of developing cancer – in some cases up to 200 times higher – than the general population, a new study finds. But the individual risk of any one child getting cancer still remains very small, the study authors stressed. Overall, the U.S. National Cancer Institute (NCI) study found that the risk for cancer among children who received transplants was 19 times higher than in the general population. Non-Hodgkin's lymphoma was the cancer with a 200 times higher risk. Seventy-one percent of those who developed cancer after a pediatric organ transplant had non-Hodgkin's lymphoma, the study findings showed. "We knew going into the study that the risk of lymphoma would be very high," explained Dr. Eric Engels, the study's senior investigator. "That's been seen in much smaller studies, and it's been ... Read more

Related support groups: Cancer, Leukemia, Renal Transplant, Non-Hodgkin's Lymphoma, Organ Transplant - Rejection Prophylaxis, Viral Infection, Kidney Transplant, Organ Transplant, Organ Transplant - Rejection Reversal, Rejection Reversal, Rejection Prophylaxis

Baseball Great Rod Carew Owes His Life to NFL Player's Transplanted Organs

Posted 17 Apr 2017 by Drugs.com

MONDAY, April 17, 2017 – When Baseball Hall of Famer Rod Carew received a new heart and kidney last December, he and his family had no idea who they had to thank for the lifesaving organs. But some good sleuthing by Carew's wife and the mother of the anonymous donor unearthed a startling discovery: The organs had come from former National Football League tight end Konrad Reuland, who was only 29 when he died after suffering a brain aneurysm. Carew, 71, needed the new organs because of a massive heart attack he had in 2015, which was followed by subsequent complications. He received the new organs in an operation performed at Cedars-Sinai Medical Center in Los Angeles. After the transplant, a number of Carew's family and friends asked Carew's wife, Rhonda, if the new organs might have come from Reuland. That prompted her to begin investigating. She learned the donor was a healthy local ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Kidney Transplant, Organ Transplant, Cardiothoracic Surgery, Rejection Prophylaxis

Weight, Gender Appear to Play Part in Kidney Transplant Success

Posted 31 Mar 2017 by Drugs.com

THURSDAY, March 30, 2017 – Weight and gender differences between donors and recipients can affect the success of kidney transplants, a new study says. Researchers reviewed data from more than 115,000 people in the United States who received a kidney from a deceased donor. The transplants took place between 2000 and 2014. The average follow-up time was about four years. During that time, more than 21,000 patients developed transplant failure. After accounting for other possible causes, the researchers concluded that weight was a factor in transplant failure. Specifically, if a kidney transplant recipient was more than 66 pounds heavier than the donor, there was a 28 percent higher risk of transplant failure, compared with recipients who weighed about the same as donors. The researchers also noted a difference if the donor and recipient's genders were mismatched. The risk of transplant ... Read more

Related support groups: Obesity, Renal Transplant, Kidney Transplant, Organ Transplant

Cystic Fibrosis Survival Better in Canada Than in U.S.

Posted 14 Mar 2017 by Drugs.com

MONDAY, March 13, 2017 – People with cystic fibrosis are living longer than ever, but those in Canada live nearly 10 years longer than those in the United States, a new study finds. Cystic fibrosis is a genetic disease that affects the lungs and digestive tract. It causes the production of a thick, sticky mucus that clogs the lungs. This may cause life-threatening lung infections. People with cystic fibrosis also have difficulty properly breaking down and absorbing nutrients from food, the researchers explained. Between 2009 and 2013, the average Canadian with cystic fibrosis lived to just under 51 years. In the United States, someone with the lung disorder could expect to live an average of close to 41 years, the study found. Why the difference? Although the study didn't specifically look at the reasons behind the gap, possible reasons include diet, better access to lung transplants ... Read more

Related support groups: Cystic Fibrosis, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Respiratory Tract Disease, Rejection Reversal, Rejection Prophylaxis, Cystic Fibrosis with Ileus

Kidney Transplant Survival Up Among Babies, Kids

Posted 7 Mar 2017 by Drugs.com

MONDAY, March 6, 2017 – Survival rates for children who get kidney transplants have improved significantly over the last half-century, a new study finds. "The outlook for infants and children with end-stage kidney disease was once dismal, with poor survival rates after transplant. There has been great progress in pediatric kidney transplantation, and now the patient survival rate is almost 100 percent," said the study's principal investigator, Dr. Srinath Chinnakotla. Chinnakotla is an associate professor of surgery at the University of Minnesota Masonic Children's Hospital in Minneapolis, where the study was done. Since 2002, 97 percent of children who had kidney transplants at the hospital were alive a year later. That compares to 85 percent 40 to 50 years ago, the study showed. Long-term outcomes have also improved. Only 42 percent of kids who got a new kidney between 1963 and 1983 ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Kidney Transplant, Organ Transplant, Rejection Prophylaxis

Non-English Speakers Less Likely to Be on Kidney Transplant List

Posted 9 Feb 2017 by Drugs.com

THURSDAY, Feb. 9, 2017 – Language barriers may prevent some eligible U.S. patients from receiving a kidney transplant, a new study suggests. Specifically, those who don't speak English may be less likely to complete the kidney transplant evaluation necessary for them to be placed on a waiting list for a kidney from a deceased donor. For the study, researchers analyzed data from kidney failure patients across the United States. The investigators found that patients who lived in neighborhoods where more than 20 percent of households didn't speak English were 29 percent less likely to be on a kidney transplant waiting list than those in neighborhoods where less than 1 percent of households didn't speak English. Although the study can't prove a cause-and-effect relationship, the researchers found the link between not speaking English and not being on a kidney transplant waiting list was ... Read more

Related support groups: Renal Failure, Renal Transplant, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Hyperphosphatemia of Renal Failure

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