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Organ Transplant - Rejection Prophylaxis News

New Technique Keeps Donor Lungs Viable Longer: Study

Posted 18 days ago by Drugs.com

FRIDAY, Nov. 18, 2016 – A technique that allows lungs destined for transplants to be preserved longer works well, a new Canadian study finds. The strategy, called ex-vivo lung perfusion (EVLP), allows preservation of lungs for up to 12 hours, instead of the standard six to eight hours. "We have been using EVLP ... to assess high-risk donor lungs [less healthy] for the last decade, and almost 300 patients have benefited from this technology at our centre to date," said study author Dr. Marcelo Cypel, a thoracic surgeon at Toronto General Hospital. With standard lung transplants, "donor lungs are transported cold to the hospital where they are warmed, evaluated and then cooled again until they are transplanted into the recipient," Cypel explained. The EVLP technique, which has now become more common, allows doctors to preserve lungs for longer periods by pumping them with a solution of ... Read more

Related support groups: Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Respiratory Failure, Graft-versus-host disease

Doctors Perform 1st U.S. Living-Donor Uterine Transplant

Posted 5 Oct 2016 by Drugs.com

WEDNESDAY, Oct. 5, 2016 – A team of doctors in Dallas is "cautiously optimistic" of success in what would be the first living-donor uterine transplant in the United States. Doctors at Baylor University Medical Center said Wednesday that they performed four of the transplants in September, but only one has proven successful. "During the past three weeks since the first surgery, we performed routine follow-up testing as part of the trial protocol on all four patients," Baylor said in a statement. "In three patients, we determined after several tests the transplanted organs were not receiving viable blood flow and the uteri were removed. Those patients are now doing well and will soon be back to normal activity." However, "The fourth patient's follow-up tests currently indicate a much different result," Baylor said. "Her tests are showing good blood flow to the uterus. There are also no ... Read more

Related support groups: Birth Control, Contraception, Female Infertility, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Diagnosis and Investigation, Rejection Prophylaxis

Organ Transplants Linked to Higher Skin Cancer Risk

Posted 21 Sep 2016 by Drugs.com

WEDNESDAY, Sept. 21, 2016 – People who have an organ transplant may be more likely to develop skin cancer, new research suggests. The finding applies to all transplant patients, even those who are nonwhite and dark-skinned, according to Dr. Christina Lee Chung, an associate professor of dermatology at Drexel University in Philadelphia, and colleagues. The researchers said the risk increases over time with ongoing exposure to medications that suppress the immune system to prevent organ rejection. Total-body skin exams should be a routine part of care after transplant surgery, the study authors advised. For the study, the researchers analyzed medical records of 413 organ transplant recipients, 63 percent of whom were not white. The investigators found 19 new skin cancers in 15 of the nonwhite patients. That group included six black patients, five Asians and four Hispanics. Among the ... Read more

Related support groups: Basal Cell Carcinoma, Renal Transplant, Melanoma, Skin Cancer, Melanoma - Metastatic, Organ Transplant - Rejection Prophylaxis, Squamous Cell Carcinoma, Organ Transplant, Kidney Transplant, Graft-versus-host disease, Rejection Prophylaxis, History - Skin Cancer

Blood Test May Rule Out Too Many Donor Hearts

Posted 21 Jun 2016 by Drugs.com

TUESDAY, June 21, 2016 – A blood test that's used to check the health of a donor heart may not accurately predict if a heart transplant will be successful, a new study finds. Placing less emphasis on this blood test could increase the number of hearts available for end-stage heart failure, the researchers said. "Heart transplantation is an incredible therapy for patients with end-stage heart failure, but there are only 2,000 to 2,400 transplants each year," said senior study author Dr. Snehal Patel. "A lot of focus has been on finding ways to sign up more people as organ donors, but there is also a problem in that only an average of one in three donor hearts are placed," explained Patel. He is an assistant professor of medicine at Montefiore Medical Center and Albert Einstein College of Medicine in New York City. The blood test in question checks levels of a protein called troponin I. ... Read more

Related support groups: Heart Attack, Myocardial Infarction, Prevention of Cardiovascular Disease, Organ Transplant - Rejection Prophylaxis, Cardiovascular Risk Reduction, Organ Transplant, Diagnosis and Investigation, Myocardial Infarction - Prophylaxis

Obama's 3-Pronged Effort to Speed Organ Transplants

Posted 13 Jun 2016 by Drugs.com

MONDAY, June 13, 2016 – The Obama administration on Monday announced wide-ranging public and private measures to speed the wait for lifesaving organ transplants in the United States. The goals include making it easier for Americans to become organ donors and increasing the number of organ transplants. Also, almost $200 million in new investments will "facilitate breakthrough research and development," the White House said in a media release. "New breakthroughs in bioengineering, transplantation, and organ preservation can further increase the number of organ transplants and improve outcomes," the President's office said. The administration has enlisted the cooperation of dozens of corporations, universities, hospitals, foundations and patient advocacy organizations in this ongoing project. Last year, more than 30,000 transplants took place in the United States, a record number. Yet ... Read more

Related support groups: Renal Transplant, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Kidney Transplant, Graft-versus-host disease, Rejection Prophylaxis, Rejection Reversal

Cancer History May Affect Survival After Organ Transplant

Posted 22 Apr 2016 by Drugs.com

FRIDAY, April 22, 2016 – Organ transplant patients who previously had cancer may be at increased risk for new cancer and early death compared to organ recipients with no cancer history, new research suggests. The findings indicate that transplant patients with a history of cancer may need closer monitoring to detect recurrent and new cancers early, the study's senior author, Dr. Nancy Baxter, said in a news release from St. Michael's Hospital in Toronto. Baxter is chief of the hospital's General Surgery Department. She and her colleagues reviewed 33 studies that included a total of nearly 400,000 patients in 12 countries. They found that organ recipients with previous cancer were 1.5 times more likely to die prematurely from any cause than those with no previous cancer. Moreover, those with previous cancer were nearly twice as likely to develop a new cancer and had three times higher ... Read more

Related support groups: Surgery, Cancer, Renal Transplant, Organ Transplant - Rejection Prophylaxis, Kidney Transplant, Graft-versus-host disease, Rejection Reversal

Doctors Report Groundbreaking HIV-to-HIV Organ Transplants

Posted 31 Mar 2016 by Drugs.com

WEDNESDAY, March 30, 2016 – Trailblazing liver and kidney transplants from an HIV-positive donor to HIV-positive recipients were announced Wednesday by surgeons at Johns Hopkins University. "A couple of weeks ago, we performed the first HIV-to-HIV liver transplant in the world and the first HIV-to-HIV kidney transplant in the United States," Dr. Dorry Segev said during a midday media briefing. Before 2013 and passage of the HIV Organ Policy Equity Act, this kind of medical advance would not have been possible, because it was illegal for HIV-positive patients to donate organs in the United States. The act allows HIV-positive donors to donate organs to patients infected with the AIDS-causing virus, Segev said. Until the law was changed, thousands of patients with HIV in need of organ transplants often risked death while waiting for a donated organ, he said. At the same time, "we were ... Read more

Related support groups: HIV Infection, Pre-Exposure Prophylaxis, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Graft-versus-host disease, Rejection Prophylaxis

Many Kidney Transplant Patients Land in ER Within 2 Years: Study

Posted 28 Mar 2016 by Drugs.com

THURSDAY, March 24, 2016 – More than half of kidney transplant recipients wind up in an emergency department within two years of their operation, a new study finds. The researchers looked at more than 10,500 kidney transplant patients in California, Florida and New York. The investigators found that ER visits were made by 12 percent of patients within one month, 40 percent of patients within one year and 57 percent of patients within two years. Forty-eight percent of those ER visits led to hospital admission, according to the study published online March 24 in the Clinical Journal of the American Society of Nephrology. Risk factors for ER visits included: younger age; being female; being black or Hispanic; having public insurance; having depression, diabetes or peripheral vascular disease; and use of ERs before the transplant. The findings shed light on the need to coordinate care for ... Read more

Related support groups: Diabetic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Diabetic Nephropathy, Organ Transplant

Paying for Kidneys Might Boost Donor Rate, Study Says

Posted 23 Mar 2016 by Drugs.com

WEDNESDAY, March 23, 2016 – If offered $50,000, nearly three out of five Americans would part with a kidney, a new study finds. "It appears that American society is ready to accept the concept of paying kidney donors," said lead researcher Dr. Thomas Peters, an emeritus professor of surgery at the University of Florida College of Medicine, in Jacksonville. However, Peters isn't suggesting that a paid market for kidneys start anytime soon, only that the idea be studied to see if it might increase the supply of kidneys. Paying for organs is illegal under the U.S. National Organ Transplant Act. When the law was enacted, "the feeling was that altruism should prevail," Peters said. "Organs should not become a commodity, and the giving was as important as receiving. "Laws should be amended or changed, so at least pilot studies regarding this question could be carried out to see if kidney ... Read more

Related support groups: Renal Failure, Chronic Kidney Disease, Organ Transplant - Rejection Prophylaxis, Peritoneal dialysis, Organ Transplant, Renal Osteodystrophy, Hyperphosphatemia of Renal Failure

Transplant From Incompatible Living Donor Boosts Kidney Patients' Survival

Posted 10 Mar 2016 by Drugs.com

WEDNESDAY, March 9, 2016 – In what experts call a possible "paradigm shift," a new study shows kidney disease patients may live far longer if they receive a transplant from an incompatible living donor rather than wait for a good match. The findings could offer another choice for kidney patients who might otherwise die waiting for a compatible deceased donor. Specifically, experts said the results offer hope to "highly sensitized" transplant candidates. That refers to patients who have a large number of immune system antibodies ready to attack a donor organ. It's common among people who've had a prior kidney transplant, according to the United Network for Organ Sharing. Patients who have had multiple blood transfusions while on dialysis, or who have been pregnant several times, can also become sensitized. Finding a compatible donor for sensitized patients is "nearly impossible," said ... Read more

Related support groups: Infections, Bacterial Infection, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Rejection Prophylaxis, Rejection Reversal

Woman Who Had 1st U.S. Uterus Transplant Loses the Organ Due to Complication

Posted 9 Mar 2016 by Drugs.com

WEDNESDAY, March 9, 2016 – The first U.S. woman to receive a transplanted uterus has had the implanted organ removed due to an unnamed "sudden complication," her doctors at the Cleveland Clinic announced Wednesday. "At this time, the circumstance of the complication is under review and more information will be shared as it becomes available," the hospital said in a statement. "There is a known risk in solid organ transplantation that the transplanted organ may have to be removed should a complication arise," the clinic added. "The medical team took all necessary precautions and measures to ensure the safety of our patient." The patient is a 26-year-old woman, identified only as Lindsey. Along with her husband Blake, she has adopted three children, but always longed to give birth to her own child. "At 16, I was told I would never have children. From that moment on," she said in a news ... Read more

Related support groups: Female Infertility, Ovulation Induction, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Organ Transplant - Rejection Reversal, Primary Ovarian Failure, Rejection Prophylaxis

3D Printing of 'Complex' Human Tissue Moves Forward

Posted 8 Mar 2016 by Drugs.com

MONDAY, March 7, 2016 – Researchers report that they've made progress toward using 3D printing technology to produce human tissue. The Harvard scientists say they've managed to create tissue in the laboratory that has vessels – potentially allowing the tissue to be fed by blood – and can survive for weeks. Despite accomplishing that feat, scientists still aren't close to producing human tissue that could be transplanted into the body and replace organs such as hearts and lungs, experts noted. But Dr. Anthony Atala, a specialist who's familiar with the study, said the new research is promising. "It shows what can happen in the laboratory when it comes to developing human-like tissue," Atala said, particularly when it comes to creating tissue that can be fed by bodily fluids, such as blood and plasma. Atala is director of the Wake Forest Institute for Regenerative Medicine at Wake ... Read more

Related support groups: Organ Transplant - Rejection Prophylaxis, Organ Transplant

First U.S. Uterus Transplant Patient Grateful for Chance to Have Children

Posted 8 Mar 2016 by Drugs.com

MONDAY, March 7, 2016 – The first American woman to receive a uterus transplant said Monday that she is grateful for the chance to try to have a child. Speaking at a morning news conference two weeks after her surgery, the 26-year-old woman – identified only as Lindsey – said that although she and her husband have adopted three kids, she has still longed to give birth to her own child. "At 16, I was told I would never have children. From that moment on, I prayed that God would allow me the opportunity to experience pregnancy," she said. The Cleveland Clinic doctors who performed the transplant said they plan to do nine more such transplants as part of a research study. The uteruses will come from deceased organ donors. In Lindsey's case, the uterus came from a woman in her 30s who died suddenly. "Our first transplant took place on Feb. 24, and our patient is doing very well," Dr. ... Read more

Related support groups: Abnormal Uterine Bleeding, Female Infertility, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Primary Ovarian Failure

Surgeons Perform First U.S. Uterus Transplant

Posted 26 Feb 2016 by Drugs.com

FRIDAY, Feb. 26, 2016 – Cleveland Clinic surgeons this week performed the nation's first uterus transplant, an experimental procedure offering women without a womb the possibility of pregnancy. The transplanted uterus came from a deceased donor, and the 26-year-old recipient was in stable condition following the nine-hour procedure, her doctors said Thursday. "Cleveland Clinic began screening candidates for uterus transplants late last year," according to a hospital news release. Women who might be candidates for such a transplant have ovaries but were either born without a uterus, have lost it or have suffered irreversible uterine damage, the hospital explained. The condition, called uterine factor infertility, affects 3 percent to 5 percent of women worldwide. One expert not involved in the procedure said it was a real advance for these patients. "The procedure is groundbreaking for ... Read more

Related support groups: Abnormal Uterine Bleeding, Delivery, Uterine Bleeding, Uterine Leiomyomata / Fibroids, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Diagnosis and Investigation, Cesarean Section, Labor Pain, Rejection Prophylaxis, Body Imaging, Labor and Delivery including Augmentation

Many Donor Livers for Sickest Patients Rejected, Study Finds

Posted 5 Feb 2016 by Drugs.com

FRIDAY, Feb. 5, 2016 – It's common for transplant centers to reject donor livers for the sickest patients on the transplant waiting list, a new study suggests. That means those patients have a higher risk of death while they wait for a lifesaving transplant, the researchers found. The new study reviewed 23,000 donor liver offers to 13,255 U.S. patients on the liver transplant waiting list between May 2007 and June 2013. It found that only 37 percent of the organ offers were accepted for the sickest patients on the list. "We found that not only is there a wide variation in acceptance rates for donor organs among transplant centers, these variations directly correlated with whether the sickest patients would die waiting for a lifesaving transplant, with patients 27 percent more likely to die without a transplant for every 5 percent decrease in a center's adjusted organ offer acceptance ... Read more

Related support groups: Cirrhosis, Organ Transplant - Rejection Prophylaxis, Organ Transplant, Liver and Pancreatic Disease, Rejection Prophylaxis

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