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Related terms: Cardiomyopathy, dilated, Cardiomyopathy, peripartum, Dilated Cardiomyopathy, Peripartum Cardiomyopathy

Hearts of Healthy People With Gene Mutations May Be 'Primed to Fail'

Posted 16 days ago by Drugs.com

WEDNESDAY, Nov. 23, 2016 – Certain gene mutations can increase the risk of heart failure in healthy people, researchers report. It had been believed that gene mutations in a protein called titin affect only people with dilated cardiomyopathy, one of the most common forms of inherited heart disease. But this study of more than 1,400 adults found that the hearts of healthy people with mutations in this gene may be "primed to fail" if affected by other genetic or environmental factors. About 35 million people worldwide may be at risk, the researchers said. "Our previous work showed that mutations in the titin gene are very common in people diagnosed with heart failure. Around 1 percent of the general population also carry these mutations, but until now it wasn't known if these are 'silent' gene changes or changes that can adversely affect the heart," said co-author Dr. Antonio de Marvao ... Read more

Related support groups: Heart Disease, Cardiomyopathy, Prevention of Cardiovascular Disease, Cardiovascular Risk Reduction, Diagnosis and Investigation, Ischemic Heart Disease, Cardiomyopathy Prophylaxis

Marijuana Use Tied to Rare, Temporary Heart Malfunction

Posted 13 Nov 2016 by Drugs.com

SUNDAY, Nov. 13, 2016 – Marijuana use might raise the risk of a rare, temporary heart muscle malfunction that can feel like a full-fledged heart attack, a new study suggests. People who used marijuana were almost twice as likely as non-users to suffer a bout of stress cardiomyopathy, a condition also known as takotsubo, said study co-author Dr. Amitoj Singh. He is chief cardiology fellow at St. Luke's University Health Network in Bethlehem, Pa. Further, pot users experiencing takotsubo were more likely to suffer a cardiac arrest or require an implanted defibrillator, compared with non-users with takotsubo, Singh said. Cardiac arrest is when the heart suddenly stops beating. "Marijuana does not appear to be entirely safe, as some of the lobbyists for marijuana are arguing," Singh said. But the study did not prove that pot causes takotsubo. Singh was to present his findings Sunday at the ... Read more

Related support groups: Dyspnea, Cardiomyopathy, Cannabis, Hypertrophic Cardiomyopathy, Restrictive Cardiomyopathy, Cardiomyopathy Prophylaxis, Broken Heart Syndrome, Idiopathic Hypertrophic Subaortic Stenosis

Treatment for 'Weak Heart' in Dogs Shows Promise

Posted 18 Jan 2016 by Drugs.com

SUNDAY, Jan. 17, 2016 – Researchers say they've developed an experimental treatment for a serious heart condition in dogs that might one day benefit people. Dogs and humans have similar cardiovascular systems and both can develop dilated cardiomyopathy, also known as "weak heart," according to researchers from the University of Washington and the University of Guelph in Ontario, Canada. The condition causes the heart muscle to become too weak to pump blood throughout the body, and eventually leads to heart failure, according to background notes with the study. It's suspected that malfunctioning proteins cause the heart to weaken. The cause of dilated cardiomyopathy is unknown, but genetics are believed to play a role, the researchers said. The condition is inherited in many dogs, and 30 percent to 50 percent of cases in people are inherited, the study authors noted. In this study, the ... Read more

Related support groups: Cardiomyopathy, Cardiovascular Conditions and Disorders

Childhood Cancer Treatment May Raise Adult Heart Disease Risk

Posted 5 Jan 2016 by Drugs.com

MONDAY, Jan. 4, 2016 – Children who survive cancer may face a higher risk of heart disease as adults, new research suggests. The lingering effects of the treatments that saved their lives as children may trigger the development of heart abnormalities that might not cause apparent symptoms, the researchers explained. The investigators found that heart disease appears to affect between 3 percent and 24 percent of pediatric cancer survivors by the time they reach their 30s. Those figures rose to between 10 and 37 percent among patients 40 and older, the study found. However, while the study revealed a link between childhood cancer treatment and later heart disease, it didn't prove cause-and-effect. "The prevalence of these cardiac findings might be expected in an older adult population, but not necessarily in this young a population," said study lead author Dr. Daniel Mulrooney. ... Read more

Related support groups: Cancer, Heart Disease, Methotrexate, Fluorouracil, Cardiac Arrhythmia, Xeloda, Cardiomyopathy, Hydroxyurea, Left Ventricular Dysfunction, Mercaptopurine, Hydrea, Carboplatin, Cisplatin, Cytoxan, Dacogen, Cyclophosphamide, Temodar, Bendamustine, Oxaliplatin, Gemzar

Why Women Should Lower Their Holiday Stress Level

Posted 23 Nov 2015 by Drugs.com

SUNDAY, Nov. 22, 2015 – The stress of making holiday time a happy time can put women at risk for heart problems, an expert warns. The pressure of tasks like cooking, buying presents, and organizing family gatherings can lead to stress that can damage their hearts, according to Dr. Karla Kurrelmeyer, a cardiologist with Houston Methodist Hospital's Heart and Vascular Center. "We have seen more than a few cases of stress-induced cardiomyopathy around the holidays. This occurs when women are under great amounts of stress for a short period of time and that stress is compounded with another traumatic event, such as a death in the family, a car accident, loss of money, etc. If it is ignored, it can be fatal," she said in a hospital news release. Stress-induced cardiomyopathy occurs when stress hormones weaken the left ventricle, the heart's main pumping chamber. The condition is most common ... Read more

Related support groups: Anxiety, Anxiety and Stress, Lisinopril, Metoprolol, Atenolol, Propranolol, Bystolic, Carvedilol, Ramipril, Bisoprolol, Coreg, Enalapril, Benazepril, Inderal, Sotalol, Toprol-XL, Lopressor, Timolol, Nadolol, Perindopril

Better Treatments Helping People With Enlarged Hearts Live Longer: Study

Posted 16 Mar 2015 by Drugs.com

SATURDAY, March 14, 2015 – Advances in treatment mean that people with an enlarged heart now live longer than they did 10 or 15 years ago, a new study finds. Researchers examined death rates and causes of death between 1992 and 2011 among 1,000 adults with the condition, which is clinically known as hypertrophic cardiomyopathy (HCM). It's a genetic condition in which the walls of the heart grow abnormally thick, impeding the heart's performance. As explained in a news release from the Minneapolis Heart Institute Foundation, the condition can trigger a dangerously rapid heart rhythm that can result in sudden cardiac death. However, this risk can be controlled with an implanted defibrillator (ICD), a device that shocks the heart back into normal rhythm. During the study period, death rates among the people with enlarged hearts were about the same as among adults in the general ... Read more

Related support groups: Cardiomyopathy, Hypertrophic Cardiomyopathy

Scientists Pinpoint Which Kids With Heart Muscle Disease Are in Most Danger

Posted 4 Sep 2013 by Drugs.com

WEDNESDAY, Sept. 4 – New research has identified key risk factors that predict which children with a potentially fatal heart muscle disease will face the greatest risk of death or need for a heart transplant. The findings could help doctors figure out which patients with hypertrophic cardiomyopathy will benefit most from transplant surgery. "If we knew who was in the gravest danger from this condition, we could evaluate them for early listing for heart transplant and follow them more closely," study leader Steven Lipshultz, director of the Batchelor Children's Research Institute at the University of Miami Miller School of Medicine, said in a news release. Hypertrophic cardiomyopathy is a condition that causes the heart muscle to thicken, which affects the ability of the heat to function properly. People with this condition are at risk for heart failure and sudden death. In the study, ... Read more

Related support groups: Cardiomyopathy

Study Pinpoints New Abnormality in 'Athlete's Heart'

Posted 19 Apr 2012 by Drugs.com

THURSDAY, April 19 – A heart characteristic linked to sudden cardiac death is more common in athletes than non-athletes, and black male athletes are much more likely to have this characteristic than other athletes, a new study finds. The characteristic – left-ventricular hyper-trabeculation (LVHT) – is a feature of certain types of cardiomyopathy (chronic disease of the heart muscle). The abnormality is the leading cause of exercise-related sudden cardiac death in athletes. Researchers looked at 692 athletes in the United Kingdom and found that nearly 7 percent of them had the abnormality, compared with 0.4 percent of non-athletes. And the condition was much more common in black male athletes (about 13 percent) than in other athletes (4 percent). None of the athletes with left-ventricular hyper-trabeculation met the diagnostic criteria for any form of cardiomyopathy. The study is ... Read more

Related support groups: Cardiomyopathy

Study Finds Gene Behind Inherited Cases of Enlarged Heart

Posted 15 Feb 2012 by Drugs.com

WEDNESDAY, Feb. 15 – Researchers have discovered a defective gene that's responsible for more than one-quarter of cases of inherited dilated cardiomyopathy, a serious heart muscle disease that often leads to heart failure by middle age. In the study, published in the Feb. 16 issue of the New England Journal of Medicine, researchers analyzed the DNA of 312 people with dilated cardiomyopathy, 231 people with another form of heart muscle disease (called hypertrophic cardiomyopathy) and 249 people with healthy hearts. The study patients with dilated cardiomyopathy had no obvious cause for their disease – such as alcoholism, heart attacks and other infections – so the researchers believed there was a genetic origin for the disease in these patients. About 27 percent of the dilated cardiomyopathy patients had mutations on the TTN gene that shortened the length of the gene. Only 1 percent ... Read more

Related support groups: Cardiomyopathy

Danon Disease Can Be Quickly Fatal, Study Finds

Posted 24 Mar 2009 by Drugs.com

TUESDAY, March 24 – A rare genetic heart disorder called Danon disease progresses rapidly and is often deadly in young people, according to a new study. The recently recognized disease is a type of cardiomyopathy, or heart muscle disorder, linked to genetic mutations in the lysosome-associated membrane protein gene (LAMP2). Until now, the natural course of the disease was unclear. Researchers from the Minneapolis Heart Institute Foundation studied seven people diagnosed with Danon disease when they were 7 to 17 years old. In six of them, diagnosis was made as the result of a heart murmur, family screening and findings on routine electrocardiogram tests or from such symptoms as chest pain and fainting. In one person, atrial fibrillation, an abnormal heart rhythm, led to the diagnosis. Within nine years of diagnosis, on average, all seven had encountered serious problems. One person had ... Read more

Related support groups: Cardiomyopathy

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Hypertrophic Cardiomyopathy, Broken Heart Syndrome, Cardiomyopathy Prophylaxis, Restrictive Cardiomyopathy, Heart Disease