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Vyvanse Side Effects

Generic name: lisdexamfetamine

Medically reviewed by Philip Thornton, DipPharm. Last updated on Aug 13, 2023.

Note: This document provides detailed information about Vyvanse Side Effects associated with lisdexamfetamine. Some dosage forms listed on this page may not apply specifically to the brand name Vyvanse.

Applies to lisdexamfetamine: oral capsule, oral tablet chewable.

Important warnings This medicine can cause some serious health issues

Oral route (capsule)

Abuse, Misuse, and Addiction. Lisdexamfetamine dimesylate has a high potential for abuse and misuse, which can lead to the development of a substance use disorder, including addiction.

Misuse and abuse of CNS stimulants, including lisdexamfetamine dimesylate, can result in overdose and death, and this risk is increased with higher doses or unapproved methods of administration, such as snorting or injection.Before prescribing lisdexamfetamine dimesylate, assess each patient’s risk for abuse, misuse, and addiction.

Educate patients and their families about these risks, proper storage of the drug, and proper disposal of any unused drug.

Throughout lisdexamfetamine dimesylate treatment, reassess each patient’s risk of abuse, misuse, and addiction and frequently monitor for signs and symptoms of abuse, misuse, and addiction.

Common side effects of Vyvanse

Some side effects of lisdexamfetamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • decreased appetite
  • headache
  • nausea
  • upper abdominal or stomach pain
  • vomiting
  • weight decreased

Less common

  • crying
  • depersonalization
  • dry mouth
  • dysphoria
  • euphoria
  • paranoia
  • quick to react or overreact emotionally
  • rapidly changing moods
  • sleepiness or unusual drowsiness

Serious side effects of Vyvanse

Along with its needed effects, lisdexamfetamine (the active ingredient contained in Vyvanse) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lisdexamfetamine:

Less common

  • uncontrolled vocal outbursts or tics (uncontrolled repeated body movements)

Incidence not known

  • agitation
  • blistering, peeling, or loosening of the skin
  • chest discomfort, pain, or tightness
  • chills
  • confusion
  • cough
  • diarrhea
  • difficulty with breathing
  • difficulty with swallowing
  • discouragement
  • dizziness
  • faintness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling sad or empty
  • fever
  • hives or welts, itching, or skin rash
  • irritability
  • joint or muscle pain
  • lack of appetite
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of interest or pleasure
  • overreactive reflexes
  • poor coordination
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of the skin
  • shivering
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sweating
  • swelling of the feet or lower legs
  • talking or acting with excitement you cannot control
  • trembling or shaking
  • trouble concentrating
  • trouble sleeping
  • twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking lisdexamfetamine:

Symptoms of overdose

Managing side effects (general information)

For healthcare professionals

Applies to lisdexamfetamine: oral capsule, oral tablet chewable.

Other

Gastrointestinal

Metabolic

Nervous system

Psychiatric

Dermatologic

Cardiovascular

Hypersensitivity

Genitourinary

Ocular

Hepatic

Musculoskeletal

Respiratory

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. (2007) "Product Information. Vyvanse (lisdexamfetamine)." Shire US Inc

3. Cerner Multum, Inc. "Australian Product Information."

Frequently asked questions

Further information

Vyvanse side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer