Pergonal Side Effects

Generic Name: menotropins

Note: This page contains side effects data for the generic drug menotropins. It is possible that some of the dosage forms included below may not apply to the brand name Pergonal.

It is possible that some side effects of Pergonal may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to menotropins: subcutaneous injection

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; nausea; pain, swelling, heat, or redness at the injection site; stomach cramps, fullness, or pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking menotropins (the active ingredient contained in Pergonal)

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast pain or enlarged breasts; calf, leg, or arm pain, swelling, redness or tenderness; change in balance; change in color of skin to a bluish color (eg, on the lips, nail beds, fingers, toes); changes in speech or vision; chest, jaw, or arm pain; confusion; coughing up blood; fainting; fast breathing; fast heartbeat; flu-like symptoms; one-sided weakness; pale skin; shortness of breath; sudden, severe nausea or vomiting; unusual sweating; weakness; yellowing of the skin or eyes.

For Healthcare Professionals

Applies to menotropins: injectable powder for injection, intramuscular powder for injection, subcutaneous powder for injection


The most frequently reported adverse drug reactions reported are abdominal pain, headache, injection site reactions, and injection site pain


Very common (10% or more): Multiple pregnancy (35.3%)
Common (1% to 10%): Ovarian Hyperstimulation Syndrome (OHSS), abnormal ovarian enlargement, ovarian disease, vaginal hemorrhage, pelvic pain, breast pain, ectopic pregnancy
Postmarketing reports: Ovarian cyst, breast complaints (including breast tenderness, breast discomfort and breast swelling)
Frequency not reported: Ovarian torsion


Common (1% to 10%): Abdominal pain, abdominal cramps, enlarged abdomen, nausea and vomiting, diarrhea, fullness and pain
Postmarketing reports: Nausea, abdominal pain lower, abdominal distension, abdominal discomfort
Frequency not reported: Diarrhea


Common (1% to 10%): Infection
Frequency not reported: Formation of antibodies


Common (1% to 10%): Injection site pain/reaction, injection site inflammation, injection site edema

Nervous system

Common (1% to 10%): Headache
Postmarketing reports: Dizziness


Common (1% to 10%): Dyspnea


Uncommon (0.1% to 1%): Thrombophlebitis, deep vein thrombosis
Postmarketing reports: Hot flush


Frequency not reported: Hypersensitivity


Postmarketing reports: Acne, rash, pruritus


Postmarketing reports: Arthralgia


Postmarketing reports: Visual disorders (blurred vision, vision impairment including amaurosis, diplopia, mydriasis, photopsia, scotoma and vitreous floaters)


Postmarketing reports: Fatigue, pyrexia

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