Menotropins Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Follicle Stimulation

Assisted reproduction technologies (ART):
Initial dose:
-225 International Units subcutaneously (SC) or intramuscularly (IM) daily.
-Menotropin may be administered together with urofollitropin, and the total combined dose should not exceed 225 international units (150 international units menotropin and 75 international units urofollitropin, or 75 international units menotropin and 150 international units urofollitropin).
Maximum dose:
-450 international units daily
-If given with urofollitropin, the total combined dose of urofollitropin and menotropin should not exceed 450 international units daily.

Duration of therapy: 7 to 20 days

Comments:
-Continue treatment until adequate follicular development is evident, then administer human chorionic gonadotropin (hCG).
-Withhold hCG if monitoring on the last day of therapy suggests an increased risk of ovarian hyperstimulation syndrome (OHSS).

Ovulation induction:
Initial dose: 150 international units SC or IM daily for the first 5 days of treatment.
Maximum dose: 450 international units daily

Duration of therapy: 7 to 12 days

Comments:
-If patient response is appropriate, give hCG 1 day after the last dose of menotropin.
-If inadequate follicle development or ovulation without subsequent pregnancy, treatment may be repeated.

Uses:
-Development of Multiple Follicles and Pregnancy in Ovulatory Women as Part of an Assisted Reproductive Technology (ART) Cycle
-Ovulation induction in patients who have previously received pituitary suppression

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Assisted reproduction:
-The dose must be individualized for each patient.
-Adjust the dose after 5 days based on ovarian response, as determined by evaluation of follicular growth and estradiol levels.
-Do not make additional dosage adjustments more than every 2 days or by more than 150 International Units at each adjustment.

Ovulation induction:
-The dose must be individualized for each patient.
-The lowest dose consistent with achieving good results should be used.
-Adjust dose based on monitoring (including serum estradiol levels and vaginal ultrasound results) of patient response.
-Do not adjust dose more than every 2 days or by more than 150 international units per adjustment.

Precautions

This drug is not recommended for use in children.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

-The first injection should be performed under direct medical supervision.

Storage requirements:
-Refrigerate or keep at room temperature, protect from light.

Reconstitution/preparation techniques:
-Use immediately after reconstitution.
-Discard unused material.

Monitoring:
-Withhold hCG if serum estradiol is greater than 2000 pg/mL, if the ovaries are abnormally enlarged, or if abdominal pain occurs; advise the patient to refrain from intercourse.
-Follow patients closely for at least 2 weeks after hCG administration.

Patient advice:
-Ovulation induction: Encourage daily intercourse, beginning on the day prior to hCG administration until ovulation becomes apparent.
-If a dose is missed, do not double the next dose.
-Inform women of the risk of ovarian hyperstimulation syndrome (OHSS) and OHSS-associated symptoms including lung and blood vessel problems and ovarian torsion.

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