Menotropins Dosage

This dosage information may not include all the information needed to use Menotropins safely and effectively. See additional information for Menotropins.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Ovulation Induction

Initial dose: 150 international units SC or IM daily for 5 days
Maintenance dose: Increase dose as needed (based on clinical monitoring) in intervals of at least 48 hours not to exceed 150 international units per adjustment. The maximum daily dose should not exceed 450 international units.
Duration: Dosing beyond 12 days is not recommended.

Usual Adult Dose for Follicle Stimulation

Initial dose:
Repronex: 225 international units SC or IM daily
Menopur: 225 international units SC daily
Maintenance dose: Increase dose as needed (based on clinical monitoring) in intervals of at least 48 hours not to exceed 150 international units per adjustment. The maximum daily dose should not exceed 450 international units.
Duration:
Repronex: Dosing beyond 12 days is not recommended.
Menopur: Dosing beyond 20 days is not recommended.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Dose adjustments should be made based on clinical monitoring, including serum estradiol levels and vaginal ultrasound results.

Precautions

A thorough gynecologic and endocrinologic evaluation, including an assessment of pelvic anatomy should be performed prior to initiation of menotropins therapy.

Patients experiencing severe pelvic pain, nausea, vomiting, and weight gain should discontinue treatment and be evaluated for Ovarian Hyperstimulation Syndrome (OHSS).

Patients with abnormally enlarged ovaries on the last day of menotropins therapy or serum estradiol levels greater than 2000 pg/mL should not receive human chorionic gonadotropin (hCG) to reduce the chance of developing OHSS.

Dialysis

Data not available

Other Comments

Once adequate follicular development is evident, hCG (5000 to 10,000 USP units) should be given one day following the last dose of menotropins.

Patients undergoing ovulation induction should be encouraged to have intercourse daily, beginning on the day prior to hCG administration until ovulation becomes apparent from the determination of progestational activity.

The lower abdomen (alternating sides) should be used for subcutaneous administration.

Safety and efficacy in pediatric patients have not been established.

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