Menotropins Side Effects
Commonly reported side effects of menotropins include ovarian hyperstimulation syndrome, headache, nausea, abdominal pain, and injection site reaction. Other side effects include respiratory tract disease, abdominal cramps, vomiting, increased cough, epigastric fullness, pain at injection site, and postoperative pain. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to menotropins: subcutaneous injection
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking menotropins:
Headache; nausea; pain, swelling, heat, or redness at the injection site; stomach cramps, fullness, or pain; vomiting.
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast pain or enlarged breasts; calf, leg, or arm pain, swelling, redness, or tenderness; change in balance; change in color of skin to a bluish color (eg, on the lips, nail beds, fingers, toes); changes in speech or vision; chest, jaw, or arm pain; confusion; coughing up blood; fainting; fast breathing; fast heartbeat; flu-like symptoms; one-sided weakness; pale skin; shortness of breath; sudden, severe nausea or vomiting; unusual sweating; weakness; yellowing of the skin or eyes.
For Healthcare Professionals
Applies to menotropins: injectable powder for injection, intramuscular powder for injection, subcutaneous powder for injection
The most frequently reported adverse drug reactions reported are abdominal pain, headache, injection site reactions, and injection site pain[Ref]
Very common (10% or more): Multiple pregnancy (35.3%)
Common (1% to 10%): Ovarian Hyperstimulation Syndrome (OHSS), abnormal ovarian enlargement, ovarian disease, vaginal hemorrhage, pelvic pain, breast pain, ectopic pregnancy
Postmarketing reports: Ovarian cyst, breast complaints (including breast tenderness, breast discomfort and breast swelling)
Frequency not reported: Ovarian torsion[Ref]
Common (1% to 10%): Abdominal pain, abdominal cramps, enlarged abdomen, nausea and vomiting, diarrhea, fullness and pain
Postmarketing reports: Nausea, abdominal pain lower, abdominal distension, abdominal discomfort
Frequency not reported: Diarrhea[Ref]
Common (1% to 10%): Infection
Frequency not reported: Formation of antibodies[Ref]
Common (1% to 10%): Injection site pain/reaction, injection site inflammation, injection site edema[Ref]
Common (1% to 10%): Headache
Postmarketing reports: Dizziness[Ref]
Common (1% to 10%): Dyspnea[Ref]
Uncommon (0.1% to 1%): Thrombophlebitis, deep vein thrombosis
Postmarketing reports: Hot flush[Ref]
Frequency not reported: Hypersensitivity[Ref]
Postmarketing reports: Acne, rash, pruritus[Ref]
Postmarketing reports: Arthralgia[Ref]
Postmarketing reports: Visual disorders (blurred vision, vision impairment including amaurosis, diplopia, mydriasis, photopsia, scotoma and vitreous floaters)[Ref]
Postmarketing reports: Fatigue, pyrexia[Ref]
1. "Product Information. Repronex (menotropins)." Ferring Pharmaceuticals Inc, Tarrytown, NY.
2. "Product Information. Menopur (menotropins)." Ferring Pharmaceuticals Inc, Tarrytown, NY.
3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
4. Cerner Multum, Inc. "Australian Product Information." O 0
Not all side effects for menotropins may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
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