Menotropins Side Effects

Some side effects of menotropins may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to menotropins: injectable powder for injection, subcutaneous powder for injection

Stop using menotropins and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Less than 2% of female patients treated with menotropins develop ovarian hyperstimulation syndrome (OHSS), especially after the first cycle of therapy. Symptoms of OHSS include swelling of the hands or legs, abdominal pain and swelling, shortness of breath, weight gain, and nausea or vomiting. OHSS can be fatal. Notify your doctor immediately or seek emergency medical attention if you develop any of these side effects.

Serious pulmonary (lung and breathing) conditions have been reported in patients using menotropins. Seek medical attention if you experience any sudden changes in your breathing.

Other side effects may also occur. Notify your doctor if you experience

• ovarian enlargement presenting as abdominal or pelvic pain, tenderness, pressure, or swelling;

• nausea, vomiting, or diarrhea;

• shortness of breath;

• pain, warmth, or tenderness centralized in an arm or leg;

• fever or chills;

• headache or drowsiness;

• weakness or aching of muscles or joints;

• breast enlargement or tenderness;

• pain, swelling, or irritation at the injection site; or

• rash.

Menotropins may increase the likelihood of multiple births. Multiple births may carry additional risk both for the mother and for the fetuses.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to menotropins: injectable powder for injection, intramuscular powder for injection, subcutaneous powder for injection

Local

Local side effects have included injection site edema and injection site reaction.

Genitourinary

Genitourinary side effects have included Ovarian Hyperstimulation Syndrome (OHSS), vaginal hemorrhage, ovarian disease, ectopic pregnancy, pelvic pain, uterine spasm, and breast tenderness.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, diarrhea, abdominal cramping, abdominal pain, abdominal fullness, constipation, and enlarged abdomen.

Nervous system

Nervous system side effects have included headache, malaise, and dizziness.

Respiratory

Respiratory side effects have included dyspnea and increased cough.

General

General side effects have included infection, back pain, and flu syndrome.

Endocrine

Endocrine side effects have included elevated estradiol levels.

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