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Pentetate calcium trisodium Side Effects

It is possible that some side effects of pentetate calcium trisodium may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to pentetate calcium trisodium: solution

As well as its needed effects, pentetate calcium trisodium may cause unwanted side effects that require medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These may include certain types of cancer, such as leukemia or bladder cancer. Discuss these possible effects with your doctor.

If any of the following side effects occur while taking pentetate calcium trisodium, check with your doctor immediately:

Incidence unknown
  • Chest pain
  • cough
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • shortness of breath
  • skin rash
  • tightness in chest
  • unusual tiredness or weakness
  • wheezing

Some pentetate calcium trisodium side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence unknown
  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at site
  • blistering, crusting, irritation, itching, or reddening of skin
  • cracked, dry, scaly skin
  • diarrhea
  • headache
  • lightheadedness
  • metallic taste
  • nausea
  • swelling

For Healthcare Professionals

Applies to pentetate calcium trisodium: injectable solution


Metabolic side effects have included the loss of zinc, magnesium, and manganese from the small intestine, skeleton, panaceas, and testes. Depletion of these endogenous metals can interfere with necessary mitotic cellular processes.[Ref]


Cardiovascular side effects have included chest pain and lightheadedness.[Ref]


Dermatologic side effects have included dermatitis.[Ref]

Nervous system

Nervous system side effects have included headache.[Ref]


Hypersensitivity side effects have included allergic reactions.[Ref]


Local side effects have included injection site reactions.[Ref]


Gastrointestinal side effects have included nausea, diarrhea, and metallic taste.[Ref]


Respiratory side effects have included cough and wheezing.[Ref]


1. "Product Information. Pentetate Calcium Trisodium (pentetate calcium trisodium)." Akorn Inc, Buffalo Grove, IL.

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