Neupogen

Pronunciation

Generic Name: filgrastim (fil GRAS tim)
Brand Names: Neupogen, Neupogen SingleJect

What is Neupogen?

Neupogen (filgrastim) is a man-made form of a protein that stimulates the growth of white blood cells in your body. White blood cells help your body fight against infection.

Neupogen is used to treat neutropenia, a lack of certain white blood cells caused by cancer, bone marrow transplant, receiving chemotherapy, or by other conditions.

Neupogen may also be used for purposes not listed in this medication guide.

Important information

You should not use Neupogen if you are allergic to filgrastim or to other medicines that contain the E. coli bacteria.

Before using Neupogen, tell your doctor if you have a blood cell disorder (such as sickle cell anemia), chronic myeloid leukemia, myelodysplasia (also called "preleukemia"), or if you are receiving chemotherapy or radiation treatment.

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Do not self-inject Neupogen if you do not fully understand how to give the injection and properly dispose of used needles, syringes, IV tubing, and other items used to inject the medicine.

To be sure Neupogen is helping your condition, your blood may need to be tested often. This will help your doctor determine how long to treat you with Neupogen. Your liver function will also need to be tested, and you may need bone density scans. Visit your doctor regularly.

Stop using Neupogen and call your doctor at once if you have a serious side effect such as sudden or severe pain in your left upper stomach spreading up to your shoulder, rapid breathing or feeling short of breath, or signs of infection (fever, chills, sore throat, flu symptoms, easy bruising or bleeding, loss of appetite, nausea and vomiting, mouth sores, or unusual weakness).

Before using Neupogen

You should not use Neupogen if you are allergic to filgrastim or to other medicines that contain the E. coli bacteria.

To make sure you can safely use Neupogen, tell your doctor if you have any of these other conditions:

  • a blood cell disorder, such as sickle cell anemia;

  • chronic myeloid leukemia;

  • myelodysplasia (also called "preleukemia"); or

  • if you are receiving chemotherapy or radiation treatment.

FDA pregnancy category C. It is not known whether Neupogen will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

See also: Pregnancy and breastfeeding warnings (in more detail)

It is not known whether filgrastim passes into breast milk or if it could harm a nursing baby. Do not use Neupogen without telling your doctor if you are breast-feeding a baby.

How should I use Neupogen?

Neupogen should not be given within the 24-hour period before or after you receive chemotherapy.

Neupogen is injected into a vein or under the skin. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, syringes, IV tubing, and other items used to inject the medicine.

Use Neupogen exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Do not shake the Neupogen bottle or prefilled syringe, or you may ruin the medicine. Prepare your dose in a syringe only when you are ready to give yourself an injection. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.

Use a different place on your arms, stomach, hips, or legs each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row.

A Neupogen vial or prefilled syringe is for one use only. Throw away after one use, even if there is still some medicine left inside. Do not use Neupogen if the expiration date on the label has passed. Call your doctor for a new prescription.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

To be sure Neupogen is helping your condition, your blood may need to be tested often. This will help your doctor determine how long to treat you with Neupogen. Your liver function will also need to be tested, and you may need bone density scans. Visit your doctor regularly.

Store this medication in the refrigerator and do not allow it to freeze. You may allow the medication to reach room temperature for 24 hours before measuring your dose in a syringe. Then place the vial back in the refrigerator. Throw away any Neupogen that has been left out at room temperature for longer than 24 hours.

What happens if I miss a dose?

Use the missed dose as soon as you remember, but not within the 24-hour period before or after you receive chemotherapy treatment. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Neupogen side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Neupogen: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Neupogen and call your doctor at once if you have a serious side effect such as:

  • sudden or severe pain in your left upper stomach spreading up to your shoulder;

  • rapid breathing or feeling short of breath; or

  • signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, unusual weakness.

Less serious Neupogen side effects may include:

  • diarrhea, constipation;

  • bone pain;

  • muscle aches;

  • hair loss;

  • headache, tired feeling;

  • mild skin rash; or

  • itching, swelling, or redness where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Neupogen?

Before using Neupogen, tell your doctor if you are also using lithium (Eskalith, Lithobid).

There may be other drugs that can interact with Neupogen. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Neupogen.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 6.01. Revision Date: 2012-09-26, 12:56:34 PM.

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