Pentetate Calcium Trisodium Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Radiation Emergency

For the treatment of internal contamination with plutonium, americium or curium if the route of contamination is unknown or multiple routes of contamination are likely:
1 g intravenously once a day

For the treatment of internal contamination with plutonium, americium or curium if the route of contamination is only by inhalation:
1 g by nebulized inhalation once a day (diluted at a 1:1 ratio with sterile water or saline)

Usual Pediatric Dose for Radiation Emergency

For the treatment of internal contamination with plutonium, americium or curium:

>12 y
if the route of contamination is unknown or multiple routes of contamination are likely:
1 g intravenously once a day
if the route of contamination is only by inhalation:
1 g by nebulized inhalation once a day (diluted at a 1:1 ratio with sterile water or saline)

<12 y
14 mg/kg intravenously once a day not to exceed 1 g/day

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Data not available

Dialysis

No adjustment recommended

Other Comments

Because pentetate calcium trisodium is associated with depletion of endogenous trace metals such as zinc, magnesium, and manganese, only a single dose of pentetate calcium trisodium is recommended. If additional chelation therapy is indicated, it is recommended that therapy be continued with pentetate zinc trisodium. If pentetate zinc trisodium, is not available, chelation therapy may continue with pentetate calcium trisodium but mineral supplements containing zinc should be given concomitantly, as appropriate.

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