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Pentetate calcium trisodium Pregnancy and Breastfeeding Warnings

Pentetate calcium trisodium is also known as: AN-DTPA

Overview

If you become pregnant or think you may be pregnant, tell your doctor before using Pentetate Calcium Trisodium (Ca-DTPA). Women who have or may have been exposed to radioactive chemicals should not breast-feed, whether or not they are receiving this treatment with medicine. Take extra care in disposing of breast milk.

Pentetate calcium trisodium Pregnancy Warnings

Pentetate calcium trisodium has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of teratogenicity based on the removal of zinc which is known to affect DNA and RNA synthesis in humans. There are no controlled data in human pregnancy. Multiple doses of pentetate calcium trisodium could result in an increased risk for adverse reproductive outcomes and thus are not recommend for use during pregnancy, except in cases of high internal radioactive contamination. In these cases, the risk of immediate and delayed radiation-induced toxicity to both the mother and the fetus should be considered in comparison to the risk of pentetate calcium trisodium toxicity. Also, because pentetate calcium trisodium is more effective than pentetate zinc trisodium in the first 24 hours after internal contamination, it may be appropriate to use a single dose of pentetate calcium trisodium with vitamin or mineral supplements that contain zinc as the initial treatment.

Pentetate calcium trisodium Breastfeeding Warnings

Radiocontaminants are known to be excreted in breast milk. Women with known or suspected internal contamination should not breast-feed, whether or not they are receiving chelation therapy. Precautions should be taken when discarding breast milk.

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