Osphena Side Effects

Generic Name: ospemifene

Note: This page contains side effects data for the generic drug ospemifene. It is possible that some of the dosage forms included below may not apply to the brand name Osphena.

It is possible that some side effects of Osphena may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to ospemifene: oral tablet

Along with its needed effects, ospemifene (the active ingredient contained in Osphena) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ospemifene:

More common
  • Change in vaginal discharge
  • pain or feeling of pressure in the pelvis
  • vaginal bleeding
Less common
  • Anxiety
  • chest pain
  • confusion
  • cough
  • difficulty with speaking
  • dizziness or lightheadedness
  • double vision
  • fainting
  • fast heartbeat
  • headache
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • pain, redness, or swelling in the arm or leg
  • slow speech
  • sudden shortness of breath or troubled breathing
Rare
  • Chest discomfort
  • nausea
  • pain or discomfort in the arms, jaw, back, or neck
  • shortness of breath
  • sweating
  • vomiting

Some side effects of ospemifene may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Feeling of warmth
  • increased sweating
  • redness of the face, neck, arms, and occasionally, upper chest
Less common
  • Muscle spasms
  • white or brownish vaginal discharge

For Healthcare Professionals

Applies to ospemifene: oral tablet

Cardiovascular

Common (1% to 10%): Hot flashes (7.5%)
Uncommon (0.1% to 1%): Hemorrhagic stroke, deep vein thrombosis
Rare (less than 0.1%): Thromboembolic stroke, myocardial infarction

Dermatologic

Common (1% to 10%): Hyperhidrosis (1.6%)

Genitourinary

Common (1% to 10%): Vaginal discharge (3.8%), genital discharge (1.3%), proliferative endometrium, endometrial thickening
Uncommon (0.1% to 1%): Uterine polyps
Rare (less than 0.1%): Simple hyperplasia without atypia

Musculoskeletal

Common (1% to 10%): Muscle spasms (3.2%)

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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