Opana Side Effects
Generic name: oxymorphone
Note: This document contains side effect information about oxymorphone. Some of the dosage forms listed on this page may not apply to the brand name Opana.
Some side effects of Opana may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to oxymorphone: oral tablet, oral tablet extended release
Other dosage forms:
Along with its needed effects, oxymorphone (the active ingredient contained in Opana) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking oxymorphone:Less common
- Blurred vision
- decreased urination
- difficult or labored breathing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry mouth
- fast, pounding, racing, or irregular heartbeat or pulse
- pounding in the ears
- rapid breathing
- sunken eyes
- swelling of the hands, ankles, or feet
- tightness in the chest
- unusual tiredness or weakness
- wrinkled skin
- Abdominal or stomach pain
- chest pain or discomfort
- cold sweats
- decrease in consciousness
- decrease in urine volume
- difficulty in passing urine (dribbling)
- difficulty with sleeping
- difficulty with swallowing
- drowsiness to profound coma
- irregular, slow, or shallow breathing
- joint pain, stiffness, or swelling
- painful urination
- pale or blue lips, fingernails, or skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- redness of the skin
- severe constipation
- severe vomiting
- skin rash
- trouble in holding or releasing urine
Get emergency help immediately if any of the following symptoms of overdose occur while taking oxymorphone:Symptoms of overdose
- Cold and clammy skin
- constricted, pinpoint, or small pupils (black part of the eye)
- decreased awareness or responsiveness
- muscle weakness
- no blood pressure or pulse
- not breathing
- severe sleepiness or unusual drowsiness
- stopping of heart
Some side effects of oxymorphone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Difficulty having a bowel movement (stool)
- feeling of constant movement of self or surroundings
- increased sweating
- nausea or vomiting
- relaxed and calm
- sensation of spinning
- Acid or sour stomach
- decreased appetite
- decreased weight
- excess air or gas in the stomach or intestines
- feeling of warmth
- feeling sad or empty
- full or bloated feeling
- lack of appetite
- loss of interest or pleasure
- passing gas
- pressure in the stomach
- redness of the face, neck, arms, and occasionally, upper chest
- stomach discomfort or upset
- swelling of the abdominal or stomach area
- trouble concentrating
- Blistering, crusting, irritation, itching, or reddening of the skin
- cracked, dry, scaly skin
- difficulty with thinking or concentrating
- disturbed color perception
- double vision
- false or unusual sense of well-being
- feeling jittery
- halos around lights
- loss of vision
- mental depression
- night blindness
- nightmares or unusually vivid dreams
- overbright appearance of lights
- sudden sweating
- tunnel vision
For Healthcare Professionals
Applies to oxymorphone: injectable solution, oral tablet, oral tablet extended release, rectal suppository
Nervous system side effects have included drowsiness, sedation, lightheadedness, unusual tiredness, weakness, headache, dysphoria, dizziness, mental impairment, CNS depression, euphoria, miosis, diplopia, blurred vision, nervousness, restlessness, confusion, mental clouding, trouble sleeping, paradoxical CNS stimulation, hallucinations, and mental depression.
Gastrointestinal side effects have included nausea, vomiting, dry mouth, constipation, biliary tract spasm, cramps or pain, loss of appetite, paralytic ileus, and toxic megacolon in patients with inflammatory bowel disease.
Cardiovascular side effects have included hypotension, orthostatic hypotension (particularly in ambulatory patients), tachycardia, bradycardia, palpitations, and flushing.
Respiratory side effects have included respiratory depression, atelectasis, allergic bronchospastic reaction, allergic laryngeal edema, apnea and allergic laryngospasm.
Genitourinary side effects have included ureteral spasm, urinary retention or hesitancy, and antidiuretic effect.
Dermatologic side effects have included sweating.
Hypersensitivity side effects have included allergic dermatitis, urticaria, skin rash, hives and/or itching, and swelling of the face.
Other side effects have included tolerance, psychological dependence, and physical dependence.
Ocular side effects including miosis, diplopia, and blurred vision have been reported.
General side effects including fatigue and asthenia have been reported.
Local side effects including injection site reactions have been reported with the use of oxymorphone (the active ingredient contained in Opana) injection.
Hepatic side effects including biliary colic have been reported.
Renal side effects including ureteral spasm, urinary hesitation, urinary retention, and oliguria have been reported.
More Opana resources
- Opana Monograph (AHFS DI)
- Opana Prescribing Information (FDA)
- Opana Consumer Overview
- Opana Advanced Consumer (Micromedex) - Includes Dosage Information
- Opana MedFacts Consumer Leaflet (Wolters Kluwer)
- Oxymorphone Prescribing Information (FDA)
- Opana ER Prescribing Information (FDA)
- Opana ER extended-release tablets MedFacts Consumer Leaflet (Wolters Kluwer)
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.