Opana Side Effects
Generic Name: oxymorphone
Note: This page contains side effects data for the generic drug oxymorphone. It is possible that some of the dosage forms included below may not apply to the brand name Opana.
It is possible that some side effects of Opana may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to oxymorphone: oral tablet, oral tablet extended release
Other dosage forms:
As well as its needed effects, oxymorphone (the active ingredient contained in Opana) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking oxymorphone, check with your doctor immediately:Less common
- Blurred vision
- decreased urination
- difficult or labored breathing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry mouth
- fast, pounding, racing, or irregular heartbeat or pulse
- pounding in the ears
- rapid breathing
- sunken eyes
- swelling of the hands, ankles, or feet
- tightness in the chest
- unusual tiredness or weakness
- wrinkled skin
- Abdominal or stomach pain
- chest pain or discomfort
- cold sweats
- decrease in consciousness
- decrease in urine volume
- difficulty in passing urine (dribbling)
- difficulty with sleeping
- difficulty with swallowing
- drowsiness to profound coma
- hives, itching, or skin rash
- irregular, slow, or shallow breathing
- joint pain, stiffness, or swelling
- painful urination
- pale or blue lips, fingernails, or skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- redness of the skin
- severe constipation
- severe vomiting
- trouble in holding or releasing urine
If any of the following symptoms of overdose occur while taking oxymorphone, get emergency help immediately:Symptoms of overdose
- Cold and clammy skin
- constricted, pinpoint, or small pupils (black part of the eye)
- decreased awareness or responsiveness
- muscle weakness
- no blood pressure or pulse
- not breathing
- severe sleepiness or unusual drowsiness
- stopping of heart
Some oxymorphone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- Difficulty having a bowel movement (stool)
- feeling of constant movement of self or surroundings
- increased sweating
- nausea or vomiting
- relaxed and calm
- sensation of spinning
- Acid or sour stomach
- decreased appetite
- decreased weight
- excess air or gas in the stomach or intestines
- feeling of warmth
- feeling sad or empty
- full or bloated feeling
- lack of appetite
- loss of interest or pleasure
- passing gas
- pressure in the stomach
- redness of the face, neck, arms, and occasionally, upper chest
- stomach discomfort or upset
- swelling of the abdominal or stomach area
- trouble concentrating
- Blistering, crusting, irritation, itching, or reddening of the skin
- cracked, dry, scaly skin
- difficulty with thinking or concentrating
- disturbed color perception
- double vision
- false or unusual sense of well-being
- feeling jittery
- halos around lights
- loss of vision
- mental depression
- night blindness
- nightmares or unusually vivid dreams
- overbright appearance of lights
- sudden sweating
- tunnel vision
For Healthcare Professionals
Applies to oxymorphone: injectable solution, oral tablet, oral tablet extended release, rectal suppository
Nervous system side effects have included drowsiness, sedation, lightheadedness, unusual tiredness, weakness, headache, dysphoria, dizziness, mental impairment, CNS depression, euphoria, miosis, diplopia, blurred vision, nervousness, restlessness, confusion, mental clouding, trouble sleeping, paradoxical CNS stimulation, hallucinations, and mental depression.
Gastrointestinal side effects have included nausea, vomiting, dry mouth, constipation, biliary tract spasm, cramps or pain, loss of appetite, paralytic ileus, and toxic megacolon in patients with inflammatory bowel disease.
Cardiovascular side effects have included hypotension, orthostatic hypotension (particularly in ambulatory patients), tachycardia, bradycardia, palpitations, and flushing.
Respiratory side effects have included respiratory depression, atelectasis, allergic bronchospastic reaction, allergic laryngeal edema, apnea and allergic laryngospasm.
Genitourinary side effects have included ureteral spasm, urinary retention or hesitancy, and antidiuretic effect.
Dermatologic side effects have included sweating.
Hypersensitivity side effects have included allergic dermatitis, urticaria, skin rash, hives and/or itching, and swelling of the face.
Other side effects have included tolerance, psychological dependence, and physical dependence.
Ocular side effects including miosis, diplopia, and blurred vision have been reported.
General side effects including fatigue and asthenia have been reported.
Local side effects including injection site reactions have been reported with the use of oxymorphone (the active ingredient contained in Opana) injection.
Hepatic side effects including biliary colic have been reported.
Renal side effects including ureteral spasm, urinary hesitation, urinary retention, and oliguria have been reported.
More about Opana (oxymorphone)
- Other brands: Numorphan
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