Oxymorphone Pregnancy and Breastfeeding Warnings

Oxymorphone is also known as: Numorphan, Numorphan HCl, Opana, Opana ER

Oxymorphone Pregnancy Warnings

Oxymorphone has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of teratogenicity. There are no controlled data in human pregnancy. As with other opioid analgesics, the prolonged use of oxymorphone in pregnancy may cause fetal-neonatal physical dependence.

Oxymorphone was reported to produce malformations in offspring of hamsters that received 1,500 times the recommended human dose on day 8 of gestation. Neonatal respiratory depression is possible when oxymorphone is used in labor. Equipment for neonatal resuscitation should be available if oxymorphone must be used in labor.

Oxymorphone Breastfeeding Warnings

There are no data on the excretion of oxymorphone into human milk. Because many drugs, including some opioids, are excreted into human milk, caution should be used when oxymorphone is administered to a nursing woman. Nursing is not recommended while a patient is receiving oxymorphone because of the possibility of sedation and/or respiratory depression in the infant.

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