NuvaRing Side Effects

Generic Name: ethinyl estradiol / etonogestrel

Note: This page contains side effects data for the generic drug ethinyl estradiol / etonogestrel. It is possible that some of the dosage forms included below may not apply to the brand name NuvaRing.

It is possible that some side effects of NuvaRing may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to ethinyl estradiol / etonogestrel: vaginal insert extended release

As well as its needed effects, ethinyl estradiol / etonogestrel may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking ethinyl estradiol / etonogestrel, check with your doctor immediately:

Incidence not known
  • Abdominal or stomach fullness
  • abdominal or stomach pain or tenderness usually after eating a meal
  • blurred vision
  • changes in skin color
  • chest pain or discomfort
  • confusion
  • constipation
  • diarrhea
  • dizziness
  • gaseous abdominal or stomach pain
  • headache
  • inability to speak
  • nausea
  • nervousness
  • numbness of the hands
  • pain or discomfort in the arms, jaw, back, or neck
  • pain
  • pains in the chest, groin, or legs, especially calves of the legs
  • pounding in the ears
  • prominent superficial veins over the affected area with tenderness and warmth
  • recurrent fever
  • seizures
  • severe headaches of sudden onset
  • slow or fast heartbeat
  • sudden loss of coordination
  • sudden onset of slurred speech
  • sudden vision changes
  • sudden and severe weakness in the arm or leg on one side
  • sweating
  • swelling of the foot or leg on one side of the body
  • temporary blindness
  • vomiting or vomiting of blood
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking ethinyl estradiol / etonogestrel, get emergency help immediately:

Symptoms of overdose
  • Menstrual changes
  • nausea
  • vaginal bleeding
  • vomiting

Some ethinyl estradiol / etonogestrel side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Cough
  • fever
  • headache
  • itching of the vagina or genital area
  • pain during sexual intercourse
  • pain or tenderness around the eyes and cheekbones
  • sore throat
  • stuffy or runny nose
  • thick, white vaginal discharge with no odor or with a mild odor
  • tightness of the chest
  • weight gain
Less common
  • Crying
  • depersonalization
  • false or unusual sense of well-being
  • hoarseness
  • mental depression
  • paranoia
  • quick to react or overreact emotionally
  • rapidly changing moods, mild feeling of sadness or discouragement that come and go
Incidence not known
  • Absent, missed, or irregular menstrual periods
  • bloody vaginal discharge
  • brown, blotchy spots on exposed skin
  • chills
  • clay-colored stools
  • contact lenses intolerance
  • dark urine
  • decreased amount or quality of milk
  • dry mouth
  • dry skin
  • fruit-like or unpleasant breath odor
  • increased hunger
  • increased thirst
  • increased urination
  • loss of appetite
  • medium to heavy, irregular vaginal bleeding between regular monthly periods, which may require the use of a pad or a tampon
  • rash
  • soreness, swelling, or discharge from the breast or breasts
  • trouble getting pregnant
  • unexplained weight loss
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to ethinyl estradiol / etonogestrel: vaginal ring

Genitourinary

Genitourinary side effects reported by 5% to 14% of women include vaginitis and leukorrhea. The most common events leading to discontinuation in 1% to 2.5% of women include foreign body sensation, coital problems, and device expulsion. Vaginal/cervical erosion or ulceration in women using ethinyl estradiol and etonogestrel vaginal ring has been rarely reported. In some cases, the ring adhered to vaginal tissue, necessitating removal by a healthcare provider. There have been rare reports of inadvertent insertions of ethinyl estradiol and etonogestrel vaginal ring into the urinary bladder, which required cystoscopic removal. Healthcare providers should assess for ring insertion into the urinary bladder in ethinyl estradiol and etonogestrel vaginal ring users who present with persistent urinary symptoms and are unable to locate the ring.

Respiratory

Respiratory side effects reported by 5% to 14% of women include upper respiratory tract infection and sinusitis.

Gastrointestinal

Gastrointestinal side effects reported by 5% to 14% of women include nausea. Combination contraceptives have been associated with reports of abdominal cramping, bloating, and vomiting.

General

General side effects reported by 5% to 14% of women include weight gain and headache. The most common adverse effect leading to discontinuation in 1% to 2.5% of women was emotional lability and weight gain.

Hematologic

Hematologic side effects associated with the use of combination hormonal contraceptives include thromboembolic disorders.

Cardiovascular

Cardiovascular side effects reported with the use of combination hormonal contraceptives include hypertension and myocardial infarction.

Hepatic

Hepatic side effects reported with the use of combination hormonal contraceptives include hepatic adenomas and benign liver tumors.

Ocular

Ocular side effects reported with the use of combination hormonal contraceptives include retinal thrombosis, changes in corneal curvature (steepening), and intolerance to contact lenses.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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