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Nasonex Side Effects

Generic Name: mometasone nasal

Note: This page contains side effects data for the generic drug mometasone nasal. It is possible that some of the dosage forms included below may not apply to the brand name Nasonex.

Common side effects of Nasonex include headache, epistaxis, and viral infection. Other side effects include upper respiratory tract infection, musculoskeletal pain, dysmenorrhea, and sinusitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to mometasone nasal: nasal spray

As well as its needed effects, mometasone nasal (the active ingredient contained in Nasonex) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking mometasone nasal, check with your doctor immediately:

More common
  • Bloody mucus or unexplained nosebleeds
  • chills
  • cold or flu-like symptoms
  • cough or hoarseness
  • fever
  • headache
  • increased abdominal or stomach pain and cramping during menstrual periods
  • muscle or bone pain
  • stuffy or runny nose
Less common
  • Chest pain
  • discharge or redness in the eye, eyelid, or inner lining of the eyelid
  • earache
  • shortness of breath
  • tightness in the chest
  • troubled breathing
  • wheezing
  • Sores inside the nose
  • white patches inside the nose or mouth
Incidence not known
  • Difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives
  • itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • skin rash
  • unusual tiredness or weakness

Some mometasone nasal side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Sore throat
Less common
  • Diarrhea
  • joint or muscle ache or pain
  • nasal burning or irritation
  • nausea
  • sneezing
  • stomach upset or discomfort following meals
Incidence not known
  • Bad, unusual, or unpleasant (after) taste or smell
  • change in taste or smell

For Healthcare Professionals

Applies to mometasone nasal: nasal implant, nasal spray


Mometasone is generally well tolerated and, due to the nature of its administration, is not inclined to produce the systemic adverse effects generally associated with the use of corticosteroids. Disturbances of taste and smell have been reported very rarely.[Ref]

Nervous system

Nervous system side effects have included headache. Headache has been reported to occur 2% more often than reported for patients taking placebo, but has been reported in as many as 36% of treated patients in some studies. Dizziness has rarely been reported.[Ref]


Local side effects have included nasal irritation, burning, dryness, and soreness in 1% to 6% of patients. Nosebleed has been reported in up to 19% of patients. Pharyngitis has been reported in 3% to 4% of patients. Intranasal mometasone may also cause sneezing. Nasal candidiasis has been reported in at least one patient. Nasal septal perforation has also been rarely reported.[Ref]


Endocrine side effects have included rare reports of suppression of the hypothalamic-pituitary-adrenal axis. The risk of adrenal suppression is less than that associated with systemic corticosteroids and should only be of concern when using higher than recommended doses.[Ref]


Gastrointestinal side effects have included rare reports of diarrhea, nausea, vomiting and dyspepsia.[Ref]


Hypersensitivity side effects have included rare reports of angioedema, pruritus, urticaria, bronchospasm, wheezing, and anaphylaxis.[Ref]


Immunologic side effects may have included the danger of infections from immune suppression. No conclusive evidence is available to support an increase in tuberculosis or viral infections in patients receiving nasal mometasone. The use of mometasone nasal (the active ingredient contained in Nasonex) in patients with these conditions is not recommended by the manufacturer.[Ref]


Other side effects have included postmarketing reports of nasal burning and irritation and rare cases of nasal septal perforation. Viral infection, flu-like symptoms,and otitis media have also been reported.[Ref]

Other side effects have also included postmarketing reports of disturbances of taste and smell.[Ref]


Genitourinary side effects have included dysmenorrhea.[Ref]


Musculoskeletal side effects have included reports of myalgia, arthralgia and musculoskeletal pain.[Ref]


Ocular side effects have included conjunctivitis.[Ref]


Respiratory side effects have included sinusitis, rhinitis, coughing, asthma, bronchitis, and upper respiratory tract infection. Nasal burning, irritation, and rare cases of nasal septal perforation have been reported.[Ref]


Cardiovascular side effects have included chest pain.[Ref]


1. Onrust SV, Lamb HM "Mometasone furoate: A review of its intranasal use in allergic rhinitis." Drugs 56 (1998): 725-45

2. "Product Information. Nasonex nasal spray (mometasone topical)." Schering Laboratories, Kenilworth, NJ.

3. Davies RJ, Nelson HS "Once-daily mometasone furoate nasal spray: efficacy and safety of a new intranasal glucocorticoid for allergic rhinitis." Clin Ther 19 (1997): 27-38;disc. 2-3

4. Graft D, Aaronson D, Chervinsky P, Kaiser H, Melamed J, Pedinoff A, Rosen JP, Schenkel EJ, Vandewalker ML, Keim A, Jensen PK, Nolop K, Mesarina-Wicki "A placebo- and active-controlled randomized trial of prophylactic treatment of seasonal allergic rhinitis with mometasone furoat aqueous nasal spray." J Allergy Clin Immunol 98 (1996): 724-31

5. Drouin M, Yang WH, Bertrand B, Van Cauwenberge P, Clement P, Dalby K, Darnell R, Ernst TM, Hebert J, Karlsson G, Luciuk G, Mazza J, Roovers M "Once daily mometasone furoate aqueous nasal spray is as effective as twice daily beclomethasone dipropionate for treating perennia allergic rhinitis patients." Ann Allergy Asthma Immunol 77 (1996): 153-60

6. Hebert JR, Nolop K, Lutsky BN "Once-daily mometasone furoate aqueous nasal spray (Nasonex) in seasonal allergic rhinitis: an active- and placebo-controlled study." Allergy 51 (1996): 569-76

7. Bronsky EA, Aaronson DW, Berkowitz RB, Chervinsky P, Graft D, Kaiser HB, Moss B, Nathan RA, Pearlman DS, Ratner PH, Adelgla "Dose ranging study of mometasone furoate (Nasonex) in seasonal allergic rhinitis." Ann Allergy Asthma Immunol 79 (1997): 51-6

8. Mandl M, Nolop K, Lutsky BN "Comparison of once daily mometasone furoate (Nasonex) and fluticasone propionate aqueous nasal sprays for the treatment of perennia rhinitis. The 194-079 Study Group." Ann Allergy Asthma Immunol 79 (1997): 237-45

9. Affrime MB, Kosoglou T, Thonoor CM, Flannery BE, Herron JM "Mometasone furoate has minimal effects on the hypothalamic-pituitary-adrenal axis when delivered at high doses." Chest 118 (2000): 1538-46

It is possible that some side effects of Nasonex may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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