Skip to Content

Mometasone nasal Side Effects

Commonly reported side effects of mometasone nasal include headache, epistaxis, and viral infection. Other side effects include upper respiratory tract infection, musculoskeletal pain, dysmenorrhea, and sinusitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to mometasone nasal: nasal spray

In addition to its needed effects, some unwanted effects may be caused by mometasone nasal. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking mometasone nasal:

More common
  • Bloody mucus or unexplained nosebleeds
  • chills
  • cold or flu-like symptoms
  • cough or hoarseness
  • fever
  • headache
  • increased abdominal or stomach pain and cramping during menstrual periods
  • muscle or bone pain
  • stuffy or runny nose
Less common
  • Chest pain
  • discharge or redness in the eye, eyelid, or inner lining of the eyelid
  • earache
  • shortness of breath
  • tightness in the chest
  • troubled breathing
  • wheezing
  • Sores inside the nose
  • white patches inside the nose or mouth
Incidence not known
  • Difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives
  • itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • skin rash
  • unusual tiredness or weakness

Some of the side effects that can occur with mometasone nasal may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Sore throat
Less common
  • Diarrhea
  • joint or muscle ache or pain
  • nasal burning or irritation
  • nausea
  • sneezing
  • stomach upset or discomfort following meals
Incidence not known
  • Bad, unusual, or unpleasant (after) taste or smell
  • change in taste or smell

For Healthcare Professionals

Applies to mometasone nasal: nasal implant, nasal spray


Mometasone is generally well tolerated and, due to the nature of its administration, is not inclined to produce the systemic adverse effects generally associated with the use of corticosteroids. Disturbances of taste and smell have been reported very rarely.[Ref]

Nervous system

Nervous system side effects have included headache. Headache has been reported to occur 2% more often than reported for patients taking placebo, but has been reported in as many as 36% of treated patients in some studies. Dizziness has rarely been reported.[Ref]


Local side effects have included nasal irritation, burning, dryness, and soreness in 1% to 6% of patients. Nosebleed has been reported in up to 19% of patients. Pharyngitis has been reported in 3% to 4% of patients. Intranasal mometasone may also cause sneezing. Nasal candidiasis has been reported in at least one patient. Nasal septal perforation has also been rarely reported.[Ref]


Endocrine side effects have included rare reports of suppression of the hypothalamic-pituitary-adrenal axis. The risk of adrenal suppression is less than that associated with systemic corticosteroids and should only be of concern when using higher than recommended doses.[Ref]


Gastrointestinal side effects have included rare reports of diarrhea, nausea, vomiting and dyspepsia.[Ref]


Hypersensitivity side effects have included rare reports of angioedema, pruritus, urticaria, bronchospasm, wheezing, and anaphylaxis.[Ref]


Immunologic side effects may have included the danger of infections from immune suppression. No conclusive evidence is available to support an increase in tuberculosis or viral infections in patients receiving nasal mometasone. The use of mometasone nasal in patients with these conditions is not recommended by the manufacturer.[Ref]


Other side effects have included postmarketing reports of nasal burning and irritation and rare cases of nasal septal perforation. Viral infection, flu-like symptoms,and otitis media have also been reported.[Ref]

Other side effects have also included postmarketing reports of disturbances of taste and smell.[Ref]


Genitourinary side effects have included dysmenorrhea.[Ref]


Musculoskeletal side effects have included reports of myalgia, arthralgia and musculoskeletal pain.[Ref]


Ocular side effects have included conjunctivitis.[Ref]


Respiratory side effects have included sinusitis, rhinitis, coughing, asthma, bronchitis, and upper respiratory tract infection. Nasal burning, irritation, and rare cases of nasal septal perforation have been reported.[Ref]


Cardiovascular side effects have included chest pain.[Ref]


1. Onrust SV, Lamb HM "Mometasone furoate: A review of its intranasal use in allergic rhinitis." Drugs 56 (1998): 725-45

2. "Product Information. Nasonex nasal spray (mometasone topical)." Schering Laboratories, Kenilworth, NJ.

3. Davies RJ, Nelson HS "Once-daily mometasone furoate nasal spray: efficacy and safety of a new intranasal glucocorticoid for allergic rhinitis." Clin Ther 19 (1997): 27-38;disc. 2-3

4. Graft D, Aaronson D, Chervinsky P, Kaiser H, Melamed J, Pedinoff A, Rosen JP, Schenkel EJ, Vandewalker ML, Keim A, Jensen PK, Nolop K, Mesarina-Wicki "A placebo- and active-controlled randomized trial of prophylactic treatment of seasonal allergic rhinitis with mometasone furoat aqueous nasal spray." J Allergy Clin Immunol 98 (1996): 724-31

5. Drouin M, Yang WH, Bertrand B, Van Cauwenberge P, Clement P, Dalby K, Darnell R, Ernst TM, Hebert J, Karlsson G, Luciuk G, Mazza J, Roovers M "Once daily mometasone furoate aqueous nasal spray is as effective as twice daily beclomethasone dipropionate for treating perennia allergic rhinitis patients." Ann Allergy Asthma Immunol 77 (1996): 153-60

6. Hebert JR, Nolop K, Lutsky BN "Once-daily mometasone furoate aqueous nasal spray (Nasonex) in seasonal allergic rhinitis: an active- and placebo-controlled study." Allergy 51 (1996): 569-76

7. Bronsky EA, Aaronson DW, Berkowitz RB, Chervinsky P, Graft D, Kaiser HB, Moss B, Nathan RA, Pearlman DS, Ratner PH, Adelgla "Dose ranging study of mometasone furoate (Nasonex) in seasonal allergic rhinitis." Ann Allergy Asthma Immunol 79 (1997): 51-6

8. Mandl M, Nolop K, Lutsky BN "Comparison of once daily mometasone furoate (Nasonex) and fluticasone propionate aqueous nasal sprays for the treatment of perennia rhinitis. The 194-079 Study Group." Ann Allergy Asthma Immunol 79 (1997): 237-45

9. Affrime MB, Kosoglou T, Thonoor CM, Flannery BE, Herron JM "Mometasone furoate has minimal effects on the hypothalamic-pituitary-adrenal axis when delivered at high doses." Chest 118 (2000): 1538-46

Not all side effects for mometasone nasal may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.