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Ketamine Side Effects

Not all side effects for ketamine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Applies to ketamine: compounding powder, injectable solution, intravenous solution

Cardiovascular

Cardiovascular side effects have included elevated blood pressure and pulse rate following administration of ketamine alone. However, hypotension and bradycardia have been observed. Arrhythmia has also been reported.

Respiratory

Respiratory side effects have included stimulated respiration, although severe depression of respiration or apnea may occur following rapid intravenous administration of ketamine. Laryngospasms and other forms of airway obstruction have occurred during ketamine anesthesia.

Ocular

Ocular side effects have included diplopia, nystagmus, and a slight elevation in intraocular pressure.

Gastrointestinal

Gastrointestinal side effects have included anorexia, nausea, and vomiting.

Musculoskeletal

Musculoskeletal side effects have included enhanced skeletal muscle tone manifested by tonic and clinic movements sometimes resembling seizures.

Local

Local side effects have included pain and exanthema at the injection site.

Dermatologic

Dermatologic side effects have included transient erythema and/or morbilliform rash.

Psychiatric

Psychiatric side effects have included anxiety, dysphoria, disorientation, insomnia, flashbacks, hallucinations, and psychotic episodes. A withdrawal syndrome with psychotic features has been described following discontinuation of long-term ketamine use.

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