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Goserelin Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 1, 2024.

Applies to goserelin: subcutaneous implant.

Serious side effects of Goserelin

Along with its needed effects, goserelin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking goserelin:

For all adults

More common

Less common

Rare

For females only

More common

Rare

For males only

More common

Less common

Rare

Other side effects of Goserelin

Some side effects of goserelin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For all adults

More common

Less common

For females only

More common

Less common

For males only

Less common

For Healthcare Professionals

Applies to goserelin: subcutaneous implant.

Genitourinary

Very common (10% or more): Sexual dysfunction (21%), erectile dysfunction (18%), lower urinary tract symptoms (13%), vaginitis, breast atrophy, breast enlargement

Common (1% to 10%): Gynecomastia, incontinence and urinary frequency (after radiotherapy), ureteric obstruction, pelvic pain

Uncommon (0.1% to 1%): Breast tenderness[Ref]

Psychiatric

Very common (10% or more): Libido decreased, emotional lability

Common (1% to 10%): Mood changes, depression, insomnia

Very rare (less than 0.01%): Psychotic disorder[Ref]

Dermatologic

Very common (10% or more): Hyperhidrosis, acne, seborrhea

Common (1% to 10%): Rash, pruritus

Frequency not reported: Alopecia[Ref]

Cardiovascular

Very common (10% or more): Hot flashes (62%)

Common (1% to 10%): Cardiac failure, myocardial infarction, blood pressure abnormal

Frequency not reported: QT prolongation

Postmarketing reports: Deep vein thrombosis, stroke, transient ischemic attack[Ref]

Nervous system

Very common (10% or more): Headache

Common (1% to 10%): Paresthesia, spinal cord compression, dizziness

Postmarketing reports: Convulsions[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (36%), cystitis (16%), rectal bleeding (14%)

Common (1% to 10%): Proctitis, vomiting[Ref]

Respiratory

Very common (10% or more): Pharyngitis

Common (1% to 10%): Upper respiratory infection, chronic obstructive pulmonary disease[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Drug hypersensitivity

Rare (0.01% to 0.1%): Anaphylactic reaction[Ref]

Musculoskeletal

Common (1% to 10%): Bone pain, myalgia, leg cramps, hypertonia

Uncommon (0.1% to 1%): Arthralgia

Postmarketing reports: Osteoporosis, decreased bone mineral density and bone fracture in men[Ref]

Metabolic

Common (1% to 10%): Glucose tolerance impaired, weight increased, anorexia[Ref]

Hematologic

Common (1% to 10%): Hematuria[Ref]

Endocrine

Very rare (less than 0.01%): Pituitary hemorrhage/infarction[Ref]

Oncologic

Very rare (less than 0.01%): Pituitary tumor[Ref]

Immunologic

Common (1% to 10%): Influenza syndrome[Ref]

Local

Common (1% to 10%): Injection site reaction

Other

Common (1% to 10%): Lethargy, pain, edema[Ref]

References

1. Product Information. Zoladex (goserelin). Astra-Zeneca Pharmaceuticals. 2001;PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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