Glimepiride / rosiglitazone Side Effects
Some side effects of glimepiride / rosiglitazone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to glimepiride / rosiglitazone: oral tablet
Along with its needed effects, glimepiride / rosiglitazone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking glimepiride / rosiglitazone:More common
- Body aches or pain
- difficulty with breathing
- ear congestion
- loss of voice
- nasal congestion
- runny nose
- sore throat
- unusual tiredness or weakness
- blurred vision
- chest pain or discomfort
- cold sweats
- cool, pale skin
- decreased urine output
- dilated neck veins
- extreme fatigue
- fast heartbeat
- increased hunger
- irregular breathing
- irregular heartbeat
- shortness of breath
- slurred speech
- swelling of the face, fingers, feet, or lower legs
- tightness in the chest
- troubled breathing with exertion
- unusual bleeding or bruising
- weight gain
- Abdominal or stomach pain or tenderness
- back, leg, or stomach pains
- bleeding gums
- bloody, black, or tarry stools
- blue lips and fingernails
- coughing that sometimes produces a pink frothy sputum
- dark urine
- decreased appetite
- difficult, fast, or noisy breathing, sometimes with wheezing
- fluid-filled skin blisters
- general body swelling
- increased sweating
- increased thirst
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- light-colored stools
- loss of appetite
- muscle pain or cramps
- muscle twitching
- pain or discomfort in the arms, jaw, back, or neck
- redness of the skin
- sensitivity to the sun
- skin rash
- skin thinness
- sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- yellow eyes or skin
Some side effects of glimepiride / rosiglitazone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
- Lack or loss of strength
- Burning, stinging, itching, or redness of the skin not present before therapy
For Healthcare Professionals
Applies to glimepiride / rosiglitazone: oral tablet
Endocrine side effects have included hypoglycemia.
Cardiovascular side effects have included edema and congestive heart failure.
Respiratory side effects have included upper respiratory tract infection, pulmonary edema and pleural effusions.
Nervous system side effects have included dizziness, asthenia, and headache.
General side effects have included injury.
Gastrointestinal side effects have included nausea, vomiting, gastrointestinal pain, and diarrhea,
Hepatic side effects have included elevations of liver enzyme levels, cholestasis, jaundice, and hepatitis.
Hypersensitivity side effects have included angioedema and urticaria.
Dermatologic side effects have included pruritus, erythema, urticaria, porphyria cutanea tarda, photosensitivity reactions, allergic vasculitis, and morbilliform or maculopapular eruptions.
Hematologic side effects have included leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, and pancytopenia.
Metabolic side effects have included hepatic porphyria reactions, disulfiram-like reactions, and hyponatremia. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported.
Ocular side effects have included changes in accommodation and blurred vision. New onset or worsening (diabetic) macular edema with decreased visual acuity has been reported very rarely in postmarketing experience with rosiglitazone. In some cases, symptoms improved following discontinuation of rosiglitazone. Physicians should consider the possibility of macular edema if a patient reports decreased visual acuity.
Musculoskeletal side effects have included an increased incidence of bone fracture in female patients. The majority of the fractures in the women who received rosiglitazone occurred in the upper arm, hand, and foot. These sites of fracture are different from those usually associated with postmenopausal osteoporosis (e.g., hip or spine). No increase in fracture rates was observed in men treated with rosiglitazone.
More glimepiride/rosiglitazone resources
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