Glimepiride / rosiglitazone Side Effects

Not all side effects for glimepiride / rosiglitazone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to glimepiride / rosiglitazone: oral tablet

In addition to its needed effects, some unwanted effects may be caused by glimepiride / rosiglitazone. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking glimepiride / rosiglitazone:

More common
  • Body aches or pain
  • chills
  • cough
  • difficulty with breathing
  • ear congestion
  • fever
  • headache
  • injury
  • loss of voice
  • nasal congestion
  • runny nose
  • sneezing
  • sore throat
  • unusual tiredness or weakness
Less common
  • Anxiety
  • blurred vision
  • chest pain or discomfort
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • decreased urine output
  • depression
  • dilated neck veins
  • dizziness
  • extreme fatigue
  • fast heartbeat
  • increased hunger
  • irregular breathing
  • irregular heartbeat
  • nausea
  • nightmares
  • seizures
  • shakiness
  • slurred speech
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • weight gain
Incidence not known
  • Abdominal or stomach pain or tenderness
  • agitation
  • back, leg, or stomach pains
  • bleeding gums
  • bloody, black, or tarry stools
  • blue lips and fingernails
  • coughing that sometimes produces a pink frothy sputum
  • dark urine
  • decreased appetite
  • difficult, fast, or noisy breathing, sometimes with wheezing
  • fluid-filled skin blisters
  • general body swelling
  • hostility
  • increased sweating
  • increased thirst
  • irritability
  • itching or skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • loss of appetite
  • muscle pain or cramps
  • muscle twitching
  • nosebleeds
  • pain or discomfort in the arms, jaw, back, or neck
  • redness of the skin
  • seizures
  • sensitivity to the sun
  • skin thinness
  • sores, ulcers, or white spots on the lips or in the mouth
  • stupor
  • sweating
  • swollen glands
  • vomiting
  • yellow eyes or skin

Some of the side effects that can occur with glimepiride / rosiglitazone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Lack or loss of strength
Rare
  • Burning, stinging, itching, or redness of the skin not present before treatment
Incidence not known
  • Diarrhea

For Healthcare Professionals

Applies to glimepiride / rosiglitazone: oral tablet

Endocrine

Endocrine side effects have included hypoglycemia.

Cardiovascular

Cardiovascular side effects have included edema and congestive heart failure.

Respiratory

Respiratory side effects have included upper respiratory tract infection, pulmonary edema and pleural effusions.

Nervous system

Nervous system side effects have included dizziness, asthenia, and headache.

General

General side effects have included injury.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, gastrointestinal pain, and diarrhea,

Hepatic

Hepatic side effects have included elevations of liver enzyme levels, cholestasis, jaundice, and hepatitis.

Hypersensitivity

Hypersensitivity side effects have included angioedema and urticaria.

Dermatologic

Dermatologic side effects have included pruritus, erythema, urticaria, porphyria cutanea tarda, photosensitivity reactions, allergic vasculitis, and morbilliform or maculopapular eruptions.

Hematologic

Hematologic side effects have included leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, and pancytopenia.

Metabolic

Metabolic side effects have included hepatic porphyria reactions, disulfiram-like reactions, and hyponatremia. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported.

Ocular

Ocular side effects have included changes in accommodation and blurred vision. New onset or worsening (diabetic) macular edema with decreased visual acuity has been reported very rarely in postmarketing experience with rosiglitazone. In some cases, symptoms improved following discontinuation of rosiglitazone. Physicians should consider the possibility of macular edema if a patient reports decreased visual acuity.

Musculoskeletal

Musculoskeletal side effects have included an increased incidence of bone fracture in female patients. The majority of the fractures in the women who received rosiglitazone occurred in the upper arm, hand, and foot. These sites of fracture are different from those usually associated with postmenopausal osteoporosis (e.g., hip or spine). No increase in fracture rates was observed in men treated with rosiglitazone.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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