Glimepiride/Rosiglitazone Side Effects

Please note - some side effects for Glimepiride/Rosiglitazone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Glimepiride/Rosiglitazone - for the Consumer

Glimepiride/Rosiglitazone

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Glimepiride/Rosiglitazone:

Dizziness; headache; upper respiratory tract infection; weight gain.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; confusion; fainting; fever, chills, or persistent sore throat; increased or painful urination; menstrual changes; numbness of an arm or a leg; sudden severe headache, vomiting, or dizziness; symptoms of heart failure (eg, shortness of breath; sudden unexplained weight gain; swelling of the hands, ankles, or feet); symptoms of liver problems (eg, dark urine, severe or persistent nausea, stomach pain, unexplained vomiting or loss of appetite, yellowing of the skin or eyes); symptoms of low blood sugar (eg, anxiety, chills, dizziness or drowsiness, fast heartbeat, headache, increased hunger, increased sweating, tremors); unusual bone pain; unusual bruising or bleeding; unusual tiredness or weakness; vision changes or persistent blurred vision.

Side Effects by Body System

Endocrine

Endocrine side effects have included hypoglycemia.

Cardiovascular

Cardiovascular side effects have included edema and congestive heart failure.

Respiratory

Respiratory side effects have included upper respiratory tract infection, pulmonary edema and pleural effusions.

Nervous system

Nervous system side effects have included dizziness, asthenia, and headache.

General

General side effects have included injury.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, gastrointestinal pain, and diarrhea,

Hepatic

Hepatic side effects have included elevations of liver enzyme levels, cholestasis, jaundice, and hepatitis.

Hypersensitivity

Hypersensitivity side effects have included angioedema and urticaria.

Dermatologic

Dermatologic side effects have included pruritus, erythema, urticaria, porphyria cutanea tarda, photosensitivity reactions, allergic vasculitis, and morbilliform or maculopapular eruptions.

Hematologic

Hematologic side effects have included leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, and pancytopenia.

Metabolic

Metabolic side effects have included hepatic porphyria reactions, disulfiram-like reactions, and hyponatremia. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported.

Ocular

Ocular side effects have included changes in accommodation and blurred vision. New onset or worsening (diabetic) macular edema with decreased visual acuity has been reported very rarely in postmarketing experience with rosiglitazone. In some cases, symptoms improved following discontinuation of rosiglitazone. Physicians should consider the possibility of macular edema if a patient reports decreased visual acuity.

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