Exubera Side Effects

Generic Name: insulin inhalation, rapid acting

Note: This page contains information about the side effects of insulin inhalation, rapid acting. Some of the dosage forms included on this document may not apply to the brand name Exubera.

Not all side effects for Exubera may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to insulin inhalation, rapid acting: inhalation powder

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; dry mouth; increased sputum production; runny or stuffy nose; sore throat.

Seek medical attention right away if any of these SEVERE side effects occur while taking insulin inhalation, rapid acting (the active ingredient contained in Exubera)

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; wheezing; muscle pain); changes in vision; chest pain or discomfort; chills; confusion; dizziness; drowsiness; fainting; fast or irregular heartbeat; headache; loss of consciousness; mood changes; seizures; shortness of breath; slurred speech; swelling; tremor; trouble breathing; trouble concentrating; unusual hunger; unusual sweating; weakness.

For Healthcare Professionals

Applies to insulin inhalation, rapid acting: inhalation powder


Respiratory side effects have included respiratory tract infection, increased cough, pharyngitis, rhinitis, sinusitis, dyspnea, increased sputum, bronchitis, epistaxis, laryngitis, pneumonia, and voice alteration. In clinical trials up to two years duration, patients treated with insulin inhalation demonstrated a greater decline in pulmonary function, specifically the forced expiratory volume in one second (FEV1) and the carbon monoxide diffusing capacity (DLCO), than comparator-treated patients. The mean treatment group difference in pulmonary function favoring the comparator group, was noted within the first several weeks of treatment with insulin inhalation, and did not change over the two-year treatment period.


Metabolic side effects have included hypoglycemia.


Gastrointestinal side effects have included dry mouth.


General side effects have included chest pain.

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