Insulin Inhalation, Rapid Acting Dosage
This dosage information may not include all the information needed to use Insulin Inhalation, Rapid Acting safely and effectively. See additional information for Insulin Inhalation, Rapid Acting.
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Diabetes Mellitus Type II
Initial pre-meal doses may be calculated using the following formula: [Body weight (kg) X 0.05 mg/kg = pre-meal dose (mg)] rounded down to the nearest whole milligram number (e.g., 3.7 mg rounded down to 3 mg).
A 1 mg blister of insulin inhalation is approximately equivalent to 3 units of subcutaneously injected regular human insulin. A 3 mg blister is approximately equivalent to 8 units of subcutaneously injected regular human insulin.
Patients should combine 1 mg and 3 mg blisters so that the least number of blisters per dose are taken (e.g., a 4 mg dose should be administered as one 1 mg blister and one 3 mg blister). Consecutive inhalation of three 1 mg unit dose blisters results in significantly greater insulin exposure than inhalation of one 3 mg unit dose blister. Therefore, three 1 mg doses should not be substituted for one 3 mg dose
Insulin inhalation doses should be administered immediately prior to meals (no more than 10 minutes prior to each meal).
In patients with type 1 diabetes, insulin inhalation should be used in regimens that include a longer acting insulin.
For patients with type 2 diabetes, insulin inhalation may be used as monotherapy or in combination with oral agents or longer-acting insulin.
Usual Adult Dose for Diabetes Mellitus Type I
Initial pre-meal doses may be calculated using the following formula: [Body weight (kg) X 0.05 mg/kg = pre-meal dose (mg)] rounded down to the nearest whole milligram number (e.g., 3.7 mg rounded down to 3 mg).
A 1 mg blister of insulin inhalation is approximately equivalent to 3 units of subcutaneously injected regular human insulin. A 3 mg blister is approximately equivalent to 8 units of subcutaneously injected regular human insulin.
Patients should combine 1 mg and 3 mg blisters so that the least number of blisters per dose are taken (e.g., a 4 mg dose should be administered as one 1 mg blister and one 3 mg blister). Consecutive inhalation of three 1 mg unit dose blisters results in significantly greater insulin exposure than inhalation of one 3 mg unit dose blister. Therefore, three 1 mg doses should not be substituted for one 3 mg dose
Insulin inhalation doses should be administered immediately prior to meals (no more than 10 minutes prior to each meal).
In patients with type 1 diabetes, insulin inhalation should be used in regimens that include a longer acting insulin.
For patients with type 2 diabetes, insulin inhalation may be used as monotherapy or in combination with oral agents or longer-acting insulin.
Renal Dose Adjustments
As with other insulin preparations, the dose requirements for insulin inhalation may be reduced in patients with renal impairment.
Liver Dose Adjustments
As with other insulin preparations, the dose requirements for insulin inhalation may be reduced in patients with hepatic impairment.
Precautions
All patients should have pulmonary function assessed prior to initiating therapy with insulin inhalation. Periodic monitoring of pulmonary function is recommended for patients being treated with insulin inhalation.
Dialysis
Data not available
Other Comments
Insulin inhalation has a more rapid onset of glucose-lowering activity compared to subcutaneously injected regular human insulin. Insulin inhalation has a duration of glucose-lowering activity comparable to subcutaneously injected regular human insulin and longer than rapid-acting insulin.
