Dilaudid Side Effects
Generic name: hydromorphone
Medically reviewed by Drugs.com. Last updated on Sep 15, 2023.
Note: This document contains side effect information about hydromorphone. Some dosage forms listed on this page may not apply to the brand name Dilaudid.
For Healthcare Professionals
Applies to hydromorphone: compounding powder, injectable powder for injection, injectable solution, intravenous solution, oral capsule extended release, oral liquid, oral tablet, oral tablet extended release, rectal suppository.
General
The most common adverse effects are lightheadedness, dizziness, sedation, nausea, vomiting, sweating, flushing, dysphoria, euphoria, dry mouth, and pruritus.[Ref]
Gastrointestinal
Very common (10% or more): Constipation (up to 31%), nausea (up to 28%), vomiting (up to 14%),
Common (1% to 10%): Dry mouth, dry mouth, abdominal pain, diarrhea, dyspepsia
Uncommon (0.1% to 1%): Ileus, cramps, taste alteration, gastritis, diverticulitis
Rare (less than 0.1%): Anal fissure, bezoar, duodenitis, impaired gastric emptying, painful defecation
Frequency not reported: Flatulence, dysphagia, hematochezia, abdominal distension, hemorrhoids, abnormal feces, intestinal obstruction, eructation, diverticulum, gastrointestinal motility disorder, large intestine perforation
Postmarketing reports: Oropharyngeal swelling[Ref]
Nervous system
Very common (10% or more): Somnolence (up to 15%), headache (up to 12%), dizziness (up to 11%)
Common (1% to 10%): Lightheadedness, sedation, memory impairment, hypoesthesia, paresthesia
Uncommon (0.1% to 1%): Tremor, nystagmus, increased intracranial pressure, taste alteration, involuntary muscle contractions
Rare (less than 0.1%): Hyperreflexia
Frequency not reported: Balance disorder, encephalopathy
Postmarketing reports: Convulsions, drowsiness, dyskinesia, hyperalgesia, myoclonus, serotonin syndrome (with concomitant serotonergic drugs)[Ref]
Psychiatric
Common (1% to 10%): Dysphoria, euphoria, insomnia, anxiety, depression, nervousness, nightmares, mood swings
Uncommon (0.1% to 1%): Agitation, altered mood, hallucination, disorientation, abnormal dreams
Frequency not reported: Floating feelings, dreams, apprehension, panic attack, suicide ideation, aggression
Postmarketing reports: Confusional state[Ref]
Hypersensitivity
Postmarketing reports: Anaphylactic reactions, hypersensitivity reactions[Ref]
Respiratory
Common (1% to 10%): Dyspnea
Uncommon (0.1% to 1%): Bronchospasm, laryngospasm
Frequency not reported: Respiratory depression, apnea, respiratory arrest, rhinorrhea, respiratory distress, hypoxia, sneezing, hyperventilation
Postmarketing reports: Dyspnea[Ref]
Cardiovascular
Common (1% to 10%): Flushing, hypotension, peripheral edema, chest pain
Uncommon (0.1% to 1%): Tachycardia, bradycardia, palpitations, syncope, presyncope, hypertension
Frequency not reported: Circulatory depression, cardiac arrest, shock, extrasystoles
Postmarketing reports: Peripheral edema[Ref]
Dermatologic
Common (1% to 10%): Sweating, pruritus, hyperhidrosis, rash
Uncommon (0.1% to 1%): Urticaria, diaphoresis
Frequency not reported: Erythema
Postmarketing reports: Angioedema[Ref]
Local
Uncommon (0.1% to 1%): Injection site urticaria
Postmarketing reports: Injection site reactions[Ref]
Genitourinary
Common (1% to 10%): Urinary retention, urinary hesitancy
Postmarketing reports: Erectile dysfunction[Ref]
Hepatic
Uncommon (0.1% to 1%): Biliary tract spasm
Rare (less than 0.1%): Biliary colic
Postmarketing reports: Hepatic enzyme increased[Ref]
Other
Common (1% to 10%): Asthenia (up to 11%), pain, pyrexia, fall
Uncommon (0.1% to 1%): Weakness, abnormal feeling, chills
Rare (less than 0.1%): Feeling drunk
Frequency not reported: Neonatal withdrawal syndrome, addiction, abuse, misuse, overdose, drug withdrawal syndrome, vertigo, tinnitus, malaise
Postmarketing reports: Fatigue, lethargy[Ref]
Metabolic
Common (1% to 10%): Anorexia/decreased appetite, decreased weight, dehydration
Uncommon (0.1% to 1%): Fluid retention, increased appetite, hyperuricemia[Ref]
Musculoskeletal
Common (1% to 10%): Arthralgia, muscle spasms, back pain, extremity pain
Uncommon (0.1% to 1%): Muscle rigidity
Frequency not reported: Myalgia[Ref]
Ocular
Uncommon (0.1% to 1%): Blurred vision, diplopia, miosis, visual impairment
Frequency not reported: Dry eye[Ref]
Renal
Uncommon (0.1% to 1%): Antidiuretic effects[Ref]
Endocrine
Hydromorphone (the active ingredient contained in Dilaudid)
Uncommon (0.1% to 1%): Decreased libido, sexual dysfunction
Rare (less than 0.1%): Hypogonadism
Opioids:
Postmarketing reports: Adrenal insufficiency, androgen deficiency[Ref]
Frequently asked questions
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Other brands
Dilaudid-HP, Exalgo, Palladone
Professional resources
Other brands
Dilaudid-HP, Exalgo, Palladone
Related treatment guides
References
1. Product Information. Dilaudid (hydromorphone). Knoll Pharmaceutical Company. 2001;PROD.
2. Multum Information Services, Inc. Expert Review Panel
3. Cerner Multum, Inc. UK Summary of Product Characteristics.
4. Cerner Multum, Inc. Australian Product Information.
5. Product Information. Exalgo (hydromorphone). Covidien. 2010.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.