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Hydromorphone Pregnancy and Breastfeeding Warnings

Hydromorphone is also known as: Dilaudid, Dilaudid-HP, Exalgo, Hydromorph Contin, Hydrostat IR, Palladone

Hydromorphone Pregnancy Warnings

Infants born to mothers physically dependent on hydromorphone will also be physically dependent and may exhibit respiratory difficulties and withdrawal symptoms.

Hydromorphone has been assigned to pregnancy category C by the FDA. Detailed information about the use of hydromorphone in pregnancy is not available. Animal studies have reported the occurrence of teratogenic effects at doses 600 times the human dose. Withdrawal symptoms have been reported in neonates whose mothers took other narcotic analgesics during pregnancy. In general, hydromorphone should only be given during pregnancy when benefit outweighs risk. However, the manufacturer reports that use of hydromorphone is contraindicated for obstetric analgesia.

Hydromorphone Breastfeeding Warnings

One study on eight lactating healthy women has reported that hydromorphone distributes rapidly from plasma into breast milk. However, the drug does not partition into fat. The suckling infant would receive approximately 0.67% of the maternal dose of hydromorphone (adjusted for body weight).

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