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Diethylpropion Side Effects

Not all side effects for diethylpropion may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to diethylpropion: oral tablet, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by diethylpropion. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking diethylpropion:

  • Seeing, hearing, or feeling things that are not there
  • severe mental changes
  • shortness of breath
Incidence not known
  • Black, tarry stools
  • blurred vision
  • burning while urinating
  • chest pain
  • chills
  • convulsions
  • cough or hoarseness
  • decreased ability to exercise
  • depression
  • difficult or labored breathing
  • difficult or painful urination
  • dizziness
  • fainting
  • false or unusual sense of well-being
  • fast, slow, pounding, or irregular heartbeat or pulse
  • fear or nervousness
  • fever with or without chills
  • frequent urination
  • general feeling of tiredness or weakness
  • headache
  • inability to speak
  • increased volume of pale, dilute urine
  • lower back or side pain
  • nosebleeds
  • numbness or tingling in the face, arms, or legs
  • restlessness
  • severe or sudden headache
  • shakiness in the legs, arms, hands, or feet
  • slurred speech
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the feet or lower legs
  • swollen glands
  • temporary blindness
  • tightness in the chest
  • trembling or shaking of the hands or feet
  • trouble with breathing
  • twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vision problems
  • weakness in the arm or leg on one side of the body, sudden and severe
  • wheezing

If any of the following symptoms of overdose occur while taking diethylpropion, get emergency help immediately:

Symptoms of overdose
  • Abdominal or stomach cramps
  • bigger, dilated, or enlarged pupils (black part of the eye)
  • change in consciousness
  • confusion
  • diarrhea
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • increased sensitivity of the eyes to light
  • loss of consciousness
  • nausea
  • overactive reflexes
  • panic
  • physical attempt to injure
  • restlessness
  • sweating
  • violent actions
  • vomiting

Some of the side effects that can occur with diethylpropion may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known
  • Abdominal or stomach discomfort
  • bruising
  • difficulty having a bowel movement (stool)
  • drowsiness
  • dry mouth
  • general feeling of discomfort or illness
  • hair loss
  • headache
  • hives or welts
  • indigestion
  • itching
  • large, flat, blue, or purplish patches in the skin
  • loss of appetite
  • muscle pain
  • passing of gas
  • redness of the skin
  • skin rash
  • sleeplessness
  • stomach fullness or discomfort
  • trouble sleeping
  • unable to sleep
  • unpleasant taste

For Healthcare Professionals

Applies to diethylpropion: oral tablet, oral tablet extended release


Very rare (less than 0.01%): Valvulopathy
Frequency not reported: Precordial pain, arrhythmia (including ventricular), ECG changes, tachycardia, blood pressure elevation, palpitation, valvular heart disease[Ref]


Rare (less than 0.1%): Pulmonary hypertension
Frequency not reported: Dyspnea[Ref]


Rare (less than 0.1%): Psychotic episodes
Frequency not reported: Insomnia, anxiety, euphoria, depression, dysphoria, tremor[Ref]

Nervous system

Frequency not reported: Convulsive episodes, dyskinesia, overstimulation, nervousness, restlessness, dizziness, jitteriness, somnolence, headache, cerebrovascular accident[Ref]


Frequency not reported: Urticaria, rash, ecchymosis, erythema, hair loss, increased sweating[Ref]


Frequency not reported: Impotence, libido changes, gynecomastia, menstrual upset[Ref]


Frequency not reported: Vomiting, diarrhea, abdominal discomfort, dry mouth, unpleasant taste, nausea, constipation, other GI disturbances[Ref]


Frequency not reported: Dysuria, polyuria[Ref]


Frequency not reported: Bone marrow depression, agranulocytosis, leukopenia[Ref]


Frequency not reported: Muscle pain[Ref]


Frequency not reported: Blurred vision, mydriasis[Ref]


Frequency not reported: Malaise[Ref]


1. "Product Information. Tenuate (diethylpropion)" Aventis Pharmaceuticals, Swiftwater, PA.

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