Dicyclomine Side Effects

Some side effects of dicyclomine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to dicyclomine: oral capsules and tablets, oral solution, parenteral injection

Side effects include:

Most adverse effects are manifestations of pharmacologic effects at muscarinic-cholinergic receptors and usually are reversible when therapy is discontinued.

Severity and frequency of adverse effects are dose related and individual intolerance varies greatly; although adverse effects occasionally may be obviated by a reduction in dosage, this also will likely eliminate potential therapeutic effects. If dosage of ≥80 mg daily cannnot be achieved because of intolerance, discontinue dicyclomine.

Dry mouth, dizziness, blurred vision, nausea, light-headedness (especially with the injectable form), drowsiness, weakness, nervousness.

For Healthcare Professionals

Applies to dicyclomine: compounding powder, intramuscular solution, oral capsule, oral syrup, oral tablet


Dermatologic side effects commonly observed have included inhibition of exocrine sweat glands. This is usually not clinically significant except when perspiration becomes a major factor in body temperature control.


Gastrointestinal side effects have been reported the most frequently. These have included the anticholinergic effects of dry mouth and mucous membranes. Other reported side effects have included delayed gastric emptying time, reduced gastric acid secretion, nausea, constipation, and gastroesophageal reflux.


Cardiovascular side effects have included tachycardia and palpitations from muscarinic blockade.


General side effects have included dicyclomine toxicity (anticholinergic side effects) which often presents with fever, tachycardia, agitation, and dry skin/mucous membranes.


Genitourinary side effects have frequently included urinary retention as a result of the anticholinergic effects on the urinary sphincter and dose-related, and impotence in male patients. Postmarketing reports include suppressed lactation.

Nervous system

Nervous system side effects have included lethargy and somnolence. Higher doses may be associated with mental confusion and/or excitement. The elderly appear to be more prone to the anticholinergic effects of dicyclomine on the CNS.


Ocular side effects due to the anticholinergic activity of dicyclomine have included inhibition of the iris sphincter muscle (possibly resulting in mydriasis), follicular conjunctivitis, and inhibition of the ciliary muscle (which can produce blurred vision). All muscarinic antagonists can precipitate glaucoma.


Hypersensitivity side effects have been reported rarely. These have included urticaria, pruritus, edema, hypotension, abdominal pain, tachypnea, and nausea and vomiting.


Postmarketing side effects include symptoms and cases of delirium (amnesia or transient global amnesia), nervousness, agitation, confusional state, delusion, disorientation, hallucination (including visual hallucination), and mania (mood altered and pseudodementia).


Postmarketing side effects include dyspnea and nasal congestion.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.